Inventors:
Eugene T. Michal - San Francisco CA, US
Daniel J. Lerner - Scarsdale NY, US
Matthew J. Pollman - San Francisco CA, US
International Classification:
A61K 47/48, A61M 25/10, B05D 3/00, A61P 9/10, A61P 35/00, A61K 31/337, A61K 31/573, A61K 33/24
US Classification:
424 7817, 60410302, 427 21, 514449, 514179, 424649
Abstract:
A method and device for local delivery of water-soluble or water-insoluble therapeutic agents to the surface of a normal or diseased body lumen is disclosed. An expandable structure of a medical disposable device, such as a balloon of a balloon catheter, is coated with an amphiphilic polymer coating comprising a therapeutic agent and an amphiphilic polymer or co-polymer. The medical disposable device is inserted into a body lumen, and expanded to contact the amphiphilic polymer coating against the body lumen. The total solubility of the polymer or co-polymer in vivo prevents any embolic hazard associated with the amphiphilic polymer coating.