DR. MICHAEL ZASLOFF, M.D.
Osteopathic Medicine at Linden Ln, Merion Station, PA

6388108, May 14, 2002

May 29, 2001

09/762999

Meena Rao - Monmouth Junction NJ
Binyamin Feibush - Ambler PA
William Kinney - Newtown PA
Michael Zasloff - Merion PA
Lincoln Noecker - Gilbertsville PA

Genaera Corporation - Plymouth Meeting PA

A61K 3156

552521, 552506, 552507, 552527, 552540, 552542, 552544, 552548, 552550, 552552, 552554, 552557, 552559, 552582, 552584, 552583, 552599, 514182, 514171

Newly isolated aminosterol compounds and pharmaceutical compositions based on the aminosterol compounds are described. Methods for the treatment of various disorders, for example, a microbial infection, are also described.

2013028, Oct 24, 2013

Nov 9, 2012

13/673500

Michael Zasloff - Merion PA, US
Jon Williams - Dana Point CA, US
William Kinney - Doylestown PA, US
Mark Anderson - Eagleville PA, US
Michael McLane - Landsdale PA, US

A61K 31/575

514182, 552546

A pharmaceutical composition includes, as an active ingredient, a compound according to formula 1436 as shown in FIG. , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or excipient. Various pharmaceutical products may be produced including this pharmaceutical composition. Such pharmaceutical products may be used for the treatment of obesity or diabetes. Methods for using the pharmaceutical compositions also are described. In these methods, various diseases are treated or other body functions are activated or inhibited by administering an effective amount of the pharmaceutical composition. For example, diabetes and obesity may be treated by administering an effective amount of the pharmaceutical compositions. Weight gain and growth factor production can be inhibited by administering an effective amount of these pharmaceutical compositions. Appetite can be suppressed by administering an effective amount of the pharmaceutical compositions, and a diuretic effect can be produced.

5637691, Jun 10, 1997

Aug 18, 1994

8/290826

Leah L. Frye - Ravena NY
Michael A. Zasloff - Merion Station PA
William A. Kinney - Churchville PA
Robert Moriarty - Oak Park IL

Magainin Pharmaceuticals, Inc. - Plymouth Meeting PA

C07J 1700, C07J 5300, C07J 4100

540106

Compounds having a broad range of antimicrobial activity generally have a structure including asteroid nucleus with a cationic, preferably polyamine, side chain (X) and an anionic side chain (Y). The invention is also directed to compounds of the Formula III: ##STR1## preferably where the steroid ring nucleus is saturated; the steroid ring substituent Z. sub. 5 is. alpha. -H; one Z. sub. 7 is. beta. -H and the other is. alpha. -H or. alpha. -OH; both substituents Z. sub. 12 are hydrogen; X' is a polyamine side chain of the formula --NH--(CH. sub. 2). sub. p --NH--(CH. sub. 2). sub. q --N(R. sup. II)(R. sup. III) where p and q are each independently 3 or 4, and R. sup. II and R. sup. III are each independently hydrogen or methyl; R' is methyl; and Y' is (C. sub. 1 -C. sub. 10)-alkyl substituted with a group such as --CO. sub.

5792635, Aug 11, 1998

Jun 7, 1995

8/474799

Michael Zasloff - Merion Station PA

Magainin Pharmaceuticals, Inc. - Plymouth Meeting PA

C12N 999, A61K 3156

435184

Aminosterol compounds are described that are useful as inhibitors of the sodium/proton exchanger (NHE). Methods of using such aminosterols compounds are also disclosed, including those employing compounds that are inhibitors of a spectrum of NHEs as well as those using compounds that are inhibitors of only one specific NHE. Advantageous screening techniques and assays for evaluating a compound's therapeutic activity are also disclosed.

5849490, Dec 15, 1998

Sep 13, 1996

8/713455

Barry S. Schonwetter - Philadelphia PA
Michael A. Zasloff - Merion Station PA

Magainin Pharmaceuticals, Inc. - Plymouth Meeting PA

C12Q 168

435 6

The present invention relates to an inducible antimicrobial peptide designated lingual antimicrobial peptide (LAP) which has antibacterial and antifungal activity and which can be obtained from mammalian epithelium. The prepro- and the pro- precursors of LAP are also provided. The present invention also relates to cDNA encoding LAP, the prepro- precursor or the pro-lingual precursor. In addition, methods of treating microbial infection of the epithelia are provided. Such infections can be treated by contacting the epithelia with an antimicrobially effective amount of a purified mammalian epithelial LAP or by administering a component which cause endogenous production or up-regulation of LAP.

5254535, Oct 19, 1993

Sep 5, 1989

7/402642

Michael Zasloff - Merion Station PA
Barry Berkowitz - Ft. Washington PA

The Children's Hospital of Pennsylvania - Philadelphia PA

A61K 3702, C07K 708, C07K 710

514 12

A composition comprising at least one biologically active amphiphilic peptide, said peptide being an ion channel-forming peptide, and an antibiotic selected from the class consiting of bacitracins, aminoglycosides, penicillins, monobactams, hydrophobic antibiotics, 50-S ribosome inhibitors, antibiotics having a large lipid like lactone ring, and derivatives or analogues thereof. The biologically active amphiphilic peptide and the antibiotic may be administered in amounts effective to inhibit growth of a target cell. The biologically active amphiphilic peptide and antibiotic may potentiate each other.

2003010, Jun 12, 2003

Dec 6, 2002

10/313261

Michael Zasloff - Merion PA, US

A61K031/198

514/561000

Methods and compositions for stimulating Paneth cells to release natural antimicrobial agents including peptides, to reduce or eliminate pathogenic organisms in the GI tract of mammalian bodies, including humans, utilizing an active isoleucine compound as a secretagogue.

5840936, Nov 24, 1998

Jun 7, 1995

8/475572

Michael Zasloff - Merion Station PA
Ann Shinnar - Teaneck NJ
Meena Rao - Horsham PA
William Kinney - Churchville PA

Magainin Pharmaceuticals Inc. - Plymouth Meeting PA

C07C30512, C07J 4100

552521

Aminosterol compounds are described that are useful as inhibitors of the sodium/proton exchanger (NHE). Methods of using such aminosterols compounds are also enclosed, including those employing compounds that are inhibitors of a spectrum of NHEs as well as those using compounds that are inhibitors of only one specific NHE. Advantageous screening techniques and assays for evaluating a compound's therapeutic activity are also disclosed.

5994336, Nov 30, 1999

Jun 7, 1995

8/479455

Michael Zasloff - Merion Station PA
Ann Shinnar - Teaneck NJ
William Kinney - Churchville PA
Meena Rao - Horsham PA

Magainin Pharmaceuticals Inc. - Plymouth Meeting PA

A61K 31575

514182

A method of inhibiting the proliferation of a wide variety of cells is described. This method includes administering an effective amount of a compound having the following structure: ##STR1## or a pharmaceutically acceptable salt thereof. The proliferation of the following types of cells can be inhibited by this method: lymphocytes, fibroblasts, epithelial cells, smooth muscle cells, and human ovarian cancer cells.

5202420, Apr 13, 1993

Oct 25, 1990

7/603451

Michael A. Zasloff - Merion PA
Charles L. Bevins - Drexel Hill PA
Gill Diamond - Philadelphia PA

The Children's Hospital of Philadelphia - Philadelphia PA

C07K 710, A61K 3702

530324

The present invention provides a new class of polypeptides with antimicrobial activity, termed "tracheal antimicrobial peptides," cDNA sequences encoding for the peptides and methods for the production and use thereof.