Inventors:
Edward Holmes - Durham NC
Evan Loh - Merion Station PA
Judith Swain - Stanford CA
Assignee:
The Trustees of the University of Pennsylvania - Philadelphia PA
International Classification:
C12Q 168, C12P 1934, C07H 2104
Abstract:
A method of predicting the clinical outcome of patients suffering from congestive heart failure by identifying patients with a mutant allele of the AMPD1 gene is provided. Methods for increasing survival time in patients suffering from congestive heart failure by administering compositions which inhibit AMPD1 activity are also provided.