MICHAEL KALEKO
Osteopathic Medicine at Hearthstone Ct, Rockville, MD
License number
Maryland 00024529
Category
Osteopathic Medicine
Type
Internal Medicine
Address
Address
8 Hearthstone Ct, Rockville, MD 20854
Phone
(301) 785-3782
(301) 294-2148 (Fax)
(301) 294-2148 (Fax)
Personal information
See more information about MICHAEL KALEKO at radaris.comName
Address
Phone
8 Hearthstone Ct, Potomac, MD 20854
8 Hearthstone Ct, Potomac, MD 20854
Professional information
Dr. Michael Kaleko, Rockville MD - MD (Doctor of Medicine)
Specialties:
Internal Medicine
Address:
8 Hearthstone Ct, Rockville 20854
(301) 785-3782 (Phone), (301) 294-2148 (Fax)
(301) 785-3782 (Phone), (301) 294-2148 (Fax)
Certifications:
Internal Medicine, 1986
Awards:
Healthgrades Honor Roll
Languages:
English
Education:
Medical School
Brown University / Alpert Medical School
Graduated: 1983
Vanderbilt University
University Of Washington
Brown University / Alpert Medical School
Graduated: 1983
Vanderbilt University
University Of Washington
Method For Treating Ocular Neovascularization
US Patent:
8338384, Dec 25, 2012
Filed:
May 23, 2010
Appl. No.:
12/785461
Inventors:
Romulus Kimbro Brazzell - Morrisville NC, US
Peter Anthony Campochiaro - Baltimore MD, US
Katharine Hilary Dixon - Olney MD, US
Michael Kaleko - Rockville MD, US
Tianci Luo - Clarksville MD, US
Peter Anthony Campochiaro - Baltimore MD, US
Katharine Hilary Dixon - Olney MD, US
Michael Kaleko - Rockville MD, US
Tianci Luo - Clarksville MD, US
Assignee:
Novartis AG - Basel
International Classification:
C12N 15/11
US Classification:
514 44A
Abstract:
Methods are provided for the treatment of ocular neovascularization by increasing, in an individual afflicted with ocular neovascularization, in vivo concentrations of an endostatin protein in the ocular tissues of the individual to an ocular neovascularization inhibiting effective amount, where the endostatin protein has anti-ocular neovascularization activity in vivo.
Treatment Of Diseases Characterized By Inflammation
US Patent:
2010012, May 13, 2010
Filed:
Feb 29, 2008
Appl. No.:
12/529177
Inventors:
Michael Kaleko - Rockville MD, US
Tianci Luo - Clarksville MD, US
Tianci Luo - Clarksville MD, US
Assignee:
ADVANCED VISION THERAPIES, INC. - Gaithersburg MD
International Classification:
A61K 38/16, A61P 9/10, A61P 19/02, A61P 27/00, A61K 31/7088, C12N 15/63, C07K 14/00
US Classification:
514 8, 514 12, 514 44 R, 4353201, 530350
Abstract:
The invention provides, in part, methods, nucleic acids, vectors, proteins and binding molecules that can be used to modulate a pathway such as a complement pathway. These methods and compositions can be utilized, inter alia, for the study and/or treatment of various conditions or diseases related to a complement pathway.
Bovine Immunodeficiency Virus (Biv) Based Vectors
US Patent:
7153512, Dec 26, 2006
Filed:
Mar 8, 2005
Appl. No.:
11/076353
Inventors:
Tianci Luo - Clarksville MD, US
Robert David Berkowitz - San Francisco CA, US
Michael Kaleko - Rockville MD, US
Robert David Berkowitz - San Francisco CA, US
Michael Kaleko - Rockville MD, US
Assignee:
Novartis AG - Basel
International Classification:
A61K 39/21, A01N 63/00, C12N 15/00
US Classification:
4242071, 424 931, 4353201, 435 5, 435 695, 435 912, 435455, 435456, 536 2372, 536 241, 536 242
Abstract:
This invention pertains to BIV constructs encompassing BIV combination vectors, BIV vectors and BIV packaging vectors and particularly the invention pertains to a three vector system comprising: a) a BIV vector construct including a DNA segment from a BIV genome, a packaging sequence to package RNA into virions; a promoter operably linked to the DNA segment; and a transgene operably linked to a second promoter; b) a BIV packaging vector construct comprising a BIV DNA sequence fragment comprising at least a gag gene or pol gene of BIV; a promoter operably linked to the BIV DNA fragment; and a polyadenylation sequence located downstream of the BIV DNA fragment; and c) an expression vector construct comprising a gene encoding a viral surface protein. Also provided is a method for transferring a gene of interest into a mammalian cell.
Bovine Immunodeficiency Virus (Biv) Based Vectors
US Patent:
7198793, Apr 3, 2007
Filed:
Mar 8, 2005
Appl. No.:
11/076190
Inventors:
Tianci Luo - Clarksville MD, US
Robert David Berkowitz - San Francisco CA, US
Michael Kaleko - Rockville MD, US
Robert David Berkowitz - San Francisco CA, US
Michael Kaleko - Rockville MD, US
Assignee:
Novartis AG - Basel
International Classification:
A61K 39/21, A01N 63/00, C12N 15/00
US Classification:
4242071, 424 931, 4353201, 435 5, 435 695, 435 912, 435455, 435456, 536 2372, 536 241, 536 242
Abstract:
This invention pertains to BIV constructs encompassing BIV combination vectors, BIV vectors and BIV packaging vectors and particularly the invention pertains to a three vector system comprising: a) a BIV vector construct including a DNA segment from a BIV genome, a packaging sequence to package RNA into virions; a promoter operably linked to the DNA segment; and a transgene operably linked to a second promoter; b) a BIV packaging vector construct comprising a BIV DNA sequence fragment comprising at least a gag gene or pol gene of BIV; a promoter operably linked to the BIV DNA fragment; and a polyadenylation sequence located downstream of the BIV DNA fragment; and c) an expression vector construct comprising a gene encoding a viral surface protein. Also provided is a method for transferring a gene of interest into a mammalian cell.
Adenovirus Particles With Mutagenized Fiber Proteins
US Patent:
2002013, Sep 26, 2002
Filed:
May 30, 2001
Appl. No.:
09/870203
Inventors:
Paul Hallenbeck - Gaithersburg MD, US
Neeraja Idamakanti - Gaithersburg MD, US
John Jakubczak - Germantown MD, US
Michael Kaleko - Rockville MD, US
Michele Rollence - Damascus MD, US
Theodore Smith - Ijamsville MD, US
Susan Stevenson - Frederick MD, US
David Stewart - Eldersburg MD, US
Neeraja Idamakanti - Gaithersburg MD, US
John Jakubczak - Germantown MD, US
Michael Kaleko - Rockville MD, US
Michele Rollence - Damascus MD, US
Theodore Smith - Ijamsville MD, US
Susan Stevenson - Frederick MD, US
David Stewart - Eldersburg MD, US
International Classification:
C12N015/861, C12N005/06, C12N007/00, C07K014/075
US Classification:
435/456000, 435/235100, 530/350000
Abstract:
This invention relates to mutated adenoviral fiber proteins and adenovirus particles containing such proteins. It further relates to polynucleotides encoding the proteins and vectors containing polynucleotides. It also relates to methods for making and using the adenoviral particles. With the mutated fiber proteins, the adenovirus particles no longer bind to their natural cellular receptor. They can then be “retargeted” to a specific cell type through the addition of a ligand to the virus capsid, which causes the virus to bind to and infect such cell. Specific fiber mutations are listed, which ablate binding to the natural receptor. Adenovirus particles with certain fiber mutations were found to enhance gene transfer to and expression in liver as compared to viral particles with wild-type fiber.
Method For Treating Ocular Neovascularization
US Patent:
2013016, Jun 27, 2013
Filed:
Dec 17, 2012
Appl. No.:
13/716925
Inventors:
Romulus Kimbro BRAZZELL - Morrisville NC, US
Peter Anthony CAMPOCHIARO - Baltimore MD, US
Katharine Hilary DIXON - Olney MD, US
Michael KALEKO - Rockville MD, US
Tianci LUO - Clarksville MD, US
Peter Anthony CAMPOCHIARO - Baltimore MD, US
Katharine Hilary DIXON - Olney MD, US
Michael KALEKO - Rockville MD, US
Tianci LUO - Clarksville MD, US
Assignee:
NOVARTIS AG - Basel
International Classification:
C07K 14/78
US Classification:
514 44 R
Abstract:
Methods are provided for the treatment of ocular neovascularization by increasing, in an individual afflicted with ocular neovascularization, in vivo concentrations of an endostatin protein in the ocular tissues of the individual to an ocular neovascularization inhibiting effective amount, where the endostatin protein has anti-ocular neovascularization activity in vivo.
Bovine Immunodeficiency Virus (Biv) Based Vectors
US Patent:
7202079, Apr 10, 2007
Filed:
Mar 8, 2005
Appl. No.:
11/076531
Inventors:
Tianci Luo - Clarksville MD, US
Robert David Berkowitz - San Francisco CA, US
Michael Kaleko - Rockville MD, US
Robert David Berkowitz - San Francisco CA, US
Michael Kaleko - Rockville MD, US
Assignee:
Novartis AG - Basel
International Classification:
C12N 15/00, A61K 39/00, C07H 21/00, C12N 15/87, C12P 21/06, C12P 19/34
US Classification:
4353201, 4242071, 435 5, 435 691, 435 912, 435465, 435455, 435456, 536 234, 536 2372, 536 241, 536 242
Abstract:
This invention pertains to BIV constructs encompassing BIV combination vectors, BIV vectors and BIV packaging vectors and particularly the invention pertains to a three vector system comprising: a) a BIV vector construct including a DNA segment from a BIV genome, a packaging sequence to package RNA into virions; a promoter operably linked to the DNA segment; and a transgene operably linked to a second promoter; b) a BIV packaging vector construct comprising a BIV DNA sequence fragment comprising at least a gag gene or pol gene of BIV; a promoter operably linked to the BIV DNA fragment; and a polyadenylation sequence located downstream of the BIV DNA fragment; and c) an expression vector construct comprising a gene encoding a viral surface protein. Also provided is a method for transferring a gene of interest into a mammalian cell.
Novel Oncolytic Adenoviral Vectors
US Patent:
2003010, Jun 5, 2003
Filed:
Feb 22, 2002
Appl. No.:
10/081969
Inventors:
Cheng Cheng - Rockville MD, US
Lori Clarke - Olney MD, US
Sheila Connelly - Ijamsville MD, US
David Ennist - Bethesda MD, US
Mario Gorziglia - Doylestown PA, US
Paul Hallenbeck - Gaithersburg MD, US
Carl Hay - Damascus MD, US
John Jakubczak - Germantown MD, US
Michael Kaleko - Rockville MD, US
Sandrina Phipps - Reston VA, US
Seshidhar Police - Gaithersburg MD, US
Patricia Ryan - Montgomery Village MD, US
David Stewart - Eldersburg MD, US
Yuefeng Xie - Germantown MD, US
Lori Clarke - Olney MD, US
Sheila Connelly - Ijamsville MD, US
David Ennist - Bethesda MD, US
Mario Gorziglia - Doylestown PA, US
Paul Hallenbeck - Gaithersburg MD, US
Carl Hay - Damascus MD, US
John Jakubczak - Germantown MD, US
Michael Kaleko - Rockville MD, US
Sandrina Phipps - Reston VA, US
Seshidhar Police - Gaithersburg MD, US
Patricia Ryan - Montgomery Village MD, US
David Stewart - Eldersburg MD, US
Yuefeng Xie - Germantown MD, US
International Classification:
C12N015/861, C12N009/22, C12N007/00
US Classification:
435/456000, 435/199000, 435/235100, 435/320100
Abstract:
The present invention relates to oncolytic adenoviral vectors and their use in methods of gene therapy. Provided is a recombinant viral vector comprising an adenoviral nucleic acid backbone, wherein said nucleic acid backbone comprises in sequential order: A left ITR, a termination signal sequence, an E2F responsive promoter which is operably linked to a gene essential for replication of the recombinant viral vector, an adenoviral packaging signal, and a right ITR.
Targeting Molecules
US Patent:
2002013, Sep 19, 2002
Filed:
Oct 5, 2001
Appl. No.:
09/971798
Inventors:
Michael Kaleko - Rockville MD, US
Jin Kim - Germantown MD, US
Theodore Smith - Ijamsville MD, US
Susan Stevenson - Frederick MD, US
Jin Kim - Germantown MD, US
Theodore Smith - Ijamsville MD, US
Susan Stevenson - Frederick MD, US
International Classification:
A61K038/16, C07K014/075
US Classification:
514/012000, 530/350000
Abstract:
The present invention relates to targeting molecules which are useful to specifically target an adenoviral particle to a desired cell type. These targeting molecules comprise a soluble adenoviral receptor domain, a trimerization domain, and a targeting ligand domain. Further provided are polynucleotides encoding such targeting molecule, expression vectors including such polynucleotides, and methods to target an adenoviral particle to a cell, as well as methods to deliver a heterologous gene selectively to a cell.