Inventors:
Christopher Broder - Silver Spring MD, US
Gerald Quinnan - Rockville MD, US
Assignee:
THE HENRY M. JACKSON FOUNDATION - Rockville MD
International Classification:
A61K 39/21, C12N 15/49, A61K 38/16, C12N 15/63, A61P 31/18, C12N 1/21, C12N 1/19, C12N 5/10, C07K 16/10, C07K 14/16, C12N 1/00
US Classification:
4241881, 530350, 536 2372, 514 38, 4242081, 4353201, 435243, 43525233, 4352542, 435348, 435325, 435358, 435357, 435352, 5303894
Abstract:
The present invention relates to modified HIV-1 envelope proteins where one or more N-glycosylation sites have been deleted or modified, which produce a broadly cross reactive neutralizing response, their methods of use and antibodies which bind to these proteins. The invention also provides for nucleic acids, vectors, antibodies and pharmaceutical compositions that comprise said modified HIV-1 envelope proteins.