Michael Eugene Mckeown
Psychologist at Collwood Ln, San Diego, CA
License number
Colorado 850
Issued Date
Jul 8, 1983
Renew Date
Jul 1, 2001
Expiration Date
Jun 30, 2003
Type
Licensed Psychologist
Address
Address
4421 Collwood Ln, San Diego, CA 92115
Professional information
Multimeric Forms Of Members Of The Steroid/Thyroid Superfamily Of Receptors With The Ultraspiracle Receptor
US Patent:
7119077, Oct 10, 2006
Filed:
Mar 15, 2000
Appl. No.:
09/526298
Inventors:
Ronald M. Evans - La Jolla CA, US
Michael B. McKeown - San Diego CA, US
Anthony E. Oro - San Diego CA, US
William A. Segraves - Ambler PA, US
Tso-Pang Yao - La Jolla CA, US
Michael B. McKeown - San Diego CA, US
Anthony E. Oro - San Diego CA, US
William A. Segraves - Ambler PA, US
Tso-Pang Yao - La Jolla CA, US
Assignee:
The Salk Institute for Biological Studies - La Jolla CA
International Classification:
C07H 21/04, A61K 48/00
US Classification:
514 44, 435 6, 435440, 435375
Abstract:
In accordance with the present invention, it has been discovered that various members of the steroid/thyroid superfamily of receptors can interact with the insect-derived ultraspiracle receptor, to form multimeric species. Accordingly, the interaction of at least one member of the steroid/thyroid superfamily of receptors with at least the dimerization domain of the ultraspiracle receptor modulates the ability of said member of the steroid/thyroid superfamily of receptors to transactivate transcription of genes maintained under hormone expression control in the presence of the cognate ligand for said member of the superfamily.