Inventors:
Richard E. GAMMANS - Vass NC, US
Kenneth W. Locke - Carlsbad CA, US
Michael E. Kalafer - San Diego CA, US
International Classification:
A61K 31/437, A61K 38/17, A61K 31/225, A61K 31/7076, A61K 31/4704, A61K 31/137, A61K 39/395, A61K 38/02, A61P 37/06, A61P 25/00
US Classification:
4241331, 514 179, 514547, 514 46, 514312, 514653, 514300
Abstract:
The invention contemplates methods and compositions for treating multiple sclerosis including the administration of a PDE inhibitor and at least one immunomodulator comprising mitoxantrone, natalizumab, fingolimod, laquinimod, cladribine, dimethylfumarate or a mixture comprising synthetic polypeptide analogs of myelin basic protein, including alanine, glutamic acid, lysine, and tyrosine amino acid residues, in a therapeutically effective amount. A preferred PDE inhibitor includes ibudilast.