DR. MICHAEL GOBLE, PHARM.D.
Pharmacy at Robinson Ave, San Diego, CA
License number
California 61699
Category
Pharmacy
Type
Pharmacist
Address
Address
535 Robinson Ave, San Diego, CA 92103
Phone
(619) 291-3705
Professional information
Inhibitors Of Hepatitis C Virus Rna-Dependent Rna Polymerase, And Compositions And Treatments Using The Same
US Patent:
2003019, Oct 16, 2003
Filed:
Mar 31, 2003
Appl. No.:
10/403537
Inventors:
Allen Borchardt - San Diego CA, US
Michael Goble - San Diego CA, US
Michael Goble - San Diego CA, US
Assignee:
Pfizer Inc.
International Classification:
A61K031/427, A61K031/4184, A61K031/366, C07D417/02, C 07D 4 5/02
US Classification:
514/365000, 514/394000, 514/460000, 548/204000, 548/304700, 549/292000
Abstract:
Compounds of formula I are hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp) inhibitors, and are useful in therapeutic and prophylactic treatment of persons infected with hepatitis C virus.
Compounds And Methods For Preparing Methanesulfonamides
US Patent:
2004016, Aug 26, 2004
Filed:
Nov 20, 2003
Appl. No.:
10/478594
Inventors:
Sonja Mackey - Galesburg MI, US
Michael Matison - Kalamazoo MI, US
Haifeng Wu - Portage MI, US
Paul Herrinton - Portage MI, US
Michael Goble - San Diego CA, US
Moses McMillian - Portage MI, US
Vikram Kalthod - Mattawan MI, US
Michael Matison - Kalamazoo MI, US
Haifeng Wu - Portage MI, US
Paul Herrinton - Portage MI, US
Michael Goble - San Diego CA, US
Moses McMillian - Portage MI, US
Vikram Kalthod - Mattawan MI, US
International Classification:
C07C311/35
US Classification:
564/086000
Abstract:
A process for preparing (S)-(-)-N-[4-[4-[ethyl(6-fluoro-6-methylheptyl)amino]-1-hydroxy]phenyl]methanesulfonamide hemifumarate salt, which comprises reacting N-[4[(2S)-tetrahydro-5-hydroxy-2-furanyl]phenyl]methanesulfonamide (IIa) with fluoroamine (III) in the presence of triacetoxyborohydride and ethyl acetate to provide [4-[4-[ethyl(6-fluoro-6-metylheptyl)amino]-1-hydroxy]phenyl]methanesulfonamide (I) anll then converting I into the hemifumarate salt Ia. A process for preparing IIa is also claimed as well as intermediates IIa-lId.
Compounds And Methods For Preparing Methanesulfonamides
US Patent:
7232930, Jun 19, 2007
Filed:
Feb 28, 2005
Appl. No.:
11/068287
Inventors:
Sonja Suzanne MacKey - Galesburg MI, US
Michael E. Matison - Kalamazoo MI, US
Haifeng Wu - Portage MI, US
Michael Paul Goble - San Diego CA, US
Moses W. McMillan - Portage MI, US
Vikram Gurudath Kalthod - Mattawan MI, US
Michael E. Matison - Kalamazoo MI, US
Haifeng Wu - Portage MI, US
Michael Paul Goble - San Diego CA, US
Moses W. McMillan - Portage MI, US
Vikram Gurudath Kalthod - Mattawan MI, US
Assignee:
Pharmacia & Upjohn Company - Kalamazoo MI
International Classification:
C07C 303/40, C07C 311/09, C07C 211/15
US Classification:
564 99, 549323, 549475, 560 17, 564510
Abstract:
A process for preparing (S)-(−)-N-[4-[4-[ethyl(6-fluoro-6-methylheptyl)amino]-1-hydroxy]phenyl]methanesulfonamide hemifumarate salt, which comprises reacting N-[4-[(2S)-tetrahydro-5-hydroxy-2-furanyl]phenyl]methanesulfonamide(IIa) with fluoroamine (III) in the presence of triacetoxyborohydride and ethyl acetate to provide [4-[-4-[ethyl(6-fluoro-6-methylheptyl)amino]-1-hydroxylphenyl]methanesulfonamide (I) and then converting I into the hemifumarate salt Ia. A process for preparing IIa is also claimed as well as intermediates IIa-IId.