Inventors:
David M. Sabatini - Cambridge MA, US
Dos D. Sarbassov - Shrewsbury MA, US
Michael Andreeff - Houston TX, US
Marina Konopleva - Houston TX, US
Zhihong Zeng - Houston TX, US
Francis J. Giles - San Antonio TX, US
International Classification:
A61K 31/436, C12N 5/00, C12Q 1/02, A61P 35/00
Abstract:
In certain aspects, the invention relates to methods for identifying compounds which modulate Akt activity mediated by the rictor-mTOR complex and methods for treating or preventing a disorder that is associated with aberrant Akt activity.