DR. BERT WILLIAM O'MALLEY, M.D.
Osteopathic Medicine in Houston, TX
License number
Texas E1388
Category
Osteopathic Medicine
Type
Endocrinology, Diabetes & Metabolism
License number
Texas D0012320
Category
Osteopathic Medicine
Type
Endocrinology, Diabetes & Metabolism
Address
Address
1 Baylor Plz M613, Houston, TX 77030
Phone
(713) 798-6205
(713) 798-5599 (Fax)
(713) 798-5599 (Fax)
Personal information
See more information about BERT WILLIAM O'MALLEY at radaris.comName
Address
Phone
6602 Brompton Rd, Houston, TX 77005
Houston, TX
Professional information
Expression Of Processed Recombinant Lactoferrin And Lactoferrin Polypeptide Fragments From A Fusion Product In Aspergillus
US Patent:
6080559, Jun 27, 2000
Filed:
Jun 29, 1998
Appl. No.:
9/107075
Inventors:
Orla M. Conneely - Houston TX
Denis R. Headon - Galway, IE
Bert W. O'Malley - Houston TX
Denis R. Headon - Galway, IE
Bert W. O'Malley - Houston TX
Assignee:
Agennix, Inc. - Houston TX
International Classification:
C07K 1400, C07K 1479, C12N 1562, C12N 1512, C12N 1580
US Classification:
435 697
Abstract:
The subject invention provides for the production of lactoferrins and lactoferrin polypeptide fragments using the host cells Aspergillus in combination with novel plasmid constructs. More specifically, the subject invention provides novel vector constructs capable of producing lactoferrins and lactoferrin polypeptide fragments in Aspergillus host cells. More particularly, the subject invention provides for novel plasmid constructs suitable for use with Aspergillus and especially Aspergillus awamori, niger and oryzae host cells, which enables them to produce large amounts of recombinant lactoferrins and lactoferrin polypeptide fragments.
Expression Of Processed Recombinant Lactoferrin And Lactoferrin Polypeptide Fragments From A Fusion Product In Aspergillus
US Patent:
5571697, Nov 5, 1996
Filed:
Nov 2, 1994
Appl. No.:
8/303009
Inventors:
Orla M. Conneely - Houston TX
Denis R. Headon - Galway, IE
Bert W. O'Malley - Houston TX
Denis R. Headon - Galway, IE
Bert W. O'Malley - Houston TX
Assignee:
Baylor College of Medicine Texas Medical Center - Houston TX
International Classification:
C07K 1479, C12N 1512, C12N 1562, C12N 1580
US Classification:
435 697
Abstract:
The subject invention provides for the production of lactoferrins and lactoferrin polypeptide fragments using the host cells Aspergillus in combination with novel plasmid constructs. More specifically, the subject invention provides novel vector constructs capable of producing lactoferrins and lactoferrin polypeptide fragments in Aspergillus host cells. More particularly, the subject invention provides for novel plasmid constructs suitable for use with Aspergillus and especially Aspergillus awamori, niger and oryzae host cells, which enables them to produce large amounts of recombinant lactoferrins and lactoferrin polypeptide fragments.
Mutated Steroid Hormone Receptors, Methods For Their Use And Molecular Switch For Gene Therapy
US Patent:
2002018, Dec 5, 2002
Filed:
Apr 16, 2002
Appl. No.:
10/124739
Inventors:
Bert O'Malley - Houston TX, US
Ming-Jer Tsai - Houston TX, US
Sophia Tsai - Houston TX, US
Harry Ledebur - Spring TX, US
Yaolin Wang - Iselin NJ, US
Joseph Kittle - Houston TX, US
Ming-Jer Tsai - Houston TX, US
Sophia Tsai - Houston TX, US
Harry Ledebur - Spring TX, US
Yaolin Wang - Iselin NJ, US
Joseph Kittle - Houston TX, US
Assignee:
Baylor College of Medicine
International Classification:
C12N009/22, C07H021/04, C12N005/06, C12P021/02
US Classification:
435/199000, 536/023200, 435/069100, 435/325000, 435/320100, 530/358000
Abstract:
The present invention provides mutant proteins of steroid hormone receptors. These mutant proteins are useful in methods of distinguishing a steroid hormone receptor antagonist from a steroid hormone receptor agonist. The present invention also provides plasmids containing mutated steroid hormone receptor proteins and cells transfected with those plasmids. In addition, the present invention provides methods for determining whether a compound is a steroid hormone receptor antagonist or agonist. Also, the present invention provides methods of determining endogenous ligands for steroid hormone receptors. The invention further provides a molecular switch protein for regulating expression in gene therapy.
Mutated Steroid Hormone Receptors, Methods For Their Use And Molecular Switch For Gene Therapy
US Patent:
5935934, Aug 10, 1999
Filed:
May 30, 1995
Appl. No.:
8/454418
Inventors:
Elisabetta Vegeto - Houston TX
Donald P. McDonnell - San Diego CA
Bert W. O'Malley - Houston TX
William T. Schrader - Houston TX
Ming-Jer Tsai - Houston TX
Donald P. McDonnell - San Diego CA
Bert W. O'Malley - Houston TX
William T. Schrader - Houston TX
Ming-Jer Tsai - Houston TX
Assignee:
Baylor College of Medicine - Houston TX
International Classification:
A61K 3170, A61K 4800
US Classification:
514 44
Abstract:
The present invention provides mutant proteins of steroid hormone receptors. These mutant proteins are useful in methods of distinguishing a steroid hormone receptor antagonist from a steroid hormone receptor agonist. The present invention also provides plasmids containing mutated steroid hormone receptor proteins and cells transfected with those plasmids. In addition, the present invention provides methods for determining whether a compound is a steroid hormone receptor antagonist or agonist. Also, the present invention provides methods of determining endogenous ligands for steroid hormone receptors. The invention further provides a molecular switch for regulating expression in gene therapy and methods of employing the molecular switch in humans, animals, transgenic animals and plants.
Expression Vector Systems And Method Of Use
US Patent:
5756264, May 26, 1998
Filed:
Mar 9, 1994
Appl. No.:
8/209846
Inventors:
Robert J. Schwartz - Houston TX
Franco J. DeMayo - Houston TX
Bert W. O'Malley - Houston TX
Franco J. DeMayo - Houston TX
Bert W. O'Malley - Houston TX
Assignee:
Baylor College of Medicine - Houston TX
International Classification:
C12N 510, C12N 1563
US Classification:
4353201
Abstract:
This invention relates to gene therapy by using vectors which encode stable MRNA and methods of using such vectors. In particular, this invention relates to vectors which establish controlled expression of recombinant genes within tissues at certain levels. The vector includes a 5' flanking region which includes necessary sequences for expression of a nucleic acid cassette, a 3' flanking region including a 3' UTR and/or 3' NCR which stabilizes mRNA expressed from the nucleic acid cassette, and a linker which connects the 5' flanking region to a nucleic acid sequence. The linker has a position for inserting a nucleic acid cassette. The linker does not contain the coding sequence of a gene that the linker is naturally associated with. The 3' flanking region is 3' to the position for inserting the nucleic acid cassette. The expression vectors of the present invention can also be regulated by a regulatory system and/or constructed with a coating.
Mutated Steroid Hormone Receptors, Methods For Their Use And Molecular Switch For Gene Therapy
US Patent:
5874534, Feb 23, 1999
Filed:
Jun 6, 1995
Appl. No.:
8/479846
Inventors:
Elisabetta Vegeto - Houston TX
Donald P. McDonnell - San Diego CA
Bert W. O'Malley - Houston TX
William T. Schrader - Houston TX
Ming-Jer Tsai - Houston TX
Donald P. McDonnell - San Diego CA
Bert W. O'Malley - Houston TX
William T. Schrader - Houston TX
Ming-Jer Tsai - Houston TX
Assignee:
Baylor College of Medicine - Houston TX
International Classification:
C07K 1300, C07H 2104
US Classification:
530350
Abstract:
The present invention provides mutant proteins of steroid hormone receptors. These mutant proteins are useful in methods of distinguishing a steroid hormone receptor antagonist from a steroid hormone receptor agonist. The present invention also provides plasmids containing mutated steroid hormone receptor proteins and cells transfected with those plasmids. In addition, the present invention provides methods for determining whether a compound is a steroid hormone receptor antagonist or agonist. Also, the present invention provides methods of determining endogenous ligands for steroid hormone receptors. The invention further provides a molecular switch for regulating expression in gene therapy and methods of employing the molecular switch in humans, animals, transgenic animals and plants.
Mutated Steroid Hormone Receptors, Methods For Their Use And Molecular Switch For Gene Therapy
US Patent:
2003010, Jun 12, 2003
Filed:
Apr 16, 2002
Appl. No.:
10/124741
Inventors:
Bert O'Malley - Houston TX, US
Ming-Jer Tsai - Houston TX, US
Sophia Tsai - Houston TX, US
Harry Ledebur - Spring TX, US
Yaolin Wang - Iselin NJ, US
Joseph Kittle - Houston TX, US
Ming-Jer Tsai - Houston TX, US
Sophia Tsai - Houston TX, US
Harry Ledebur - Spring TX, US
Yaolin Wang - Iselin NJ, US
Joseph Kittle - Houston TX, US
International Classification:
C07K014/72, C07H021/04, C12P021/02, C12N005/06
US Classification:
530/395000, 536/023500, 435/069700, 435/320100, 435/325000
Abstract:
The present invention provides mutant proteins of steroid hormone receptors. These mutant proteins are useful in methods of distinguishing a steroid hormone receptor antagonist from a steroid hormone receptor agonist. The present invention also provides plasmids containing mutated steroid hormone receptor proteins and cells transfected with those plasmids. In addition, the present invention provides methods for determining whether a compound is a steroid hormone receptor antagonist or agonist. Also, the present invention provides methods of determining endogenous ligands for steroid hormone receptors. The invention further provides a molecular switch protein for regulating expression in gene therapy.
Production Of Recombinant Lactoferrin And Lactoferrin Polypeptides Using Cdna Sequences In Various Organisms
US Patent:
5849881, Dec 15, 1998
Filed:
May 30, 1995
Appl. No.:
8/456106
Inventors:
Orla M. Conneely - Houston TX
Denis R. Headon - Galway, IE
Bert W. O'Malley - Houston TX
Gregory S. May - Houston TX
Denis R. Headon - Galway, IE
Bert W. O'Malley - Houston TX
Gregory S. May - Houston TX
International Classification:
C07K 1479, C07K 14435, C12N 1580, C12N 1581
US Classification:
530400
Abstract:
The verified cDNA sequences for human, bovine and porcine lactoferrin protein have been used to prepare recombinant lactoferrin for therapeutic and nutritional applications. Regions of the cDNA such as the Fe binding sites can be used to make an hLF polypeptide product.
The present invention provides novel plasmids, transfected eucaryotic cells and methods of producing these plasmids and transfected eucaryotic cells. The novel plasmid contains the cDNA for lactoferrin protein. Methods for the production of lactoferrin protein in fungi and bacteria are also provided. Thus, the present invention provides an efficient and economical means for the production of recombinant lactoferrin protein and lactoferrin related polypeptides.
Myogenic Vector Systems
US Patent:
5298422, Mar 29, 1994
Filed:
Nov 6, 1991
Appl. No.:
7/789919
Inventors:
Robert J. Schwartz - Houston TX
Franco J. DeMayo - Houston TX
Bert W. O'Malley - Houston TX
Franco J. DeMayo - Houston TX
Bert W. O'Malley - Houston TX
Assignee:
Baylor College of Medicine - Houston TX
International Classification:
C12N 1563
US Classification:
4353201
Abstract:
The present invention includes a Myogenic vector system (MVS) for the expression of a nucleic acid sequence in myogenic tissue. The MVS contains a promoter, a cassette with the sequence of interest, a 3' untranslated region (3' UTR) and contiguous noncoding region (NCR). Further enhancements can include the addition of a leader sequence, intron sequence, initiation codon and specific
This invention was partially supported by a grant from the United States government under HL-38401 awarded by the National Institute of Health. The Government has certain rights in the invention.
Production Of Recombinant Human Lactoferrin
US Patent:
5571896, Nov 5, 1996
Filed:
May 27, 1994
Appl. No.:
8/250308
Inventors:
Orla M. Conneely - Houston TX
Denis R. Headon - Galway, IE
Bert W. O'Malley - Houston TX
Gregory S. May - Houston TX
Denis R. Headon - Galway, IE
Bert W. O'Malley - Houston TX
Gregory S. May - Houston TX
Assignee:
Baylor College of Medicine - Houston TX
International Classification:
C07K 1479, C12N 1512, C12N 1562, C12N 1580
US Classification:
530400
Abstract:
The present invention provides novel plasmids, transfected eucaryotic cells and methods of producing these plasmids and transfected eucaryotic cells. The novel plasmid contains the cDNA for human lactoferrin protein. Methods for the production of human lactoferrin protein in A. Oryzae are also provided. Thus, the present invention provides an efficient and economical means for the production of recombinant human lactoferrin protein.