Inventors:
Kevin Ward - Glen Allen VA, US
R. Barbee - Glen Allen VA, US
Penny Reynolds - Gum Spring VA, US
Rakesh Kukreja - Richmond VA, US
Bruce Spiess - Manakin-Sabot VA, US
Melissa Evans - Midlothian VA, US
Eric Edwards - Richmond VA, US
International Classification:
A61K 31/33
Abstract:
Methods of modulating oxygen consumption in tissues are provided. In particular, the methods involve the administration of agents that transiently inhibit protein synthesis. The methods are used to treat ischemia and reperfusion-related injuries by temporarily decreasing oxygen consumption needs, and/or by inhibiting inflammation that results from reperfusion.