MATTHEW MORRIS TANZER
Pilots at Kemmont Dr, Durham, NC
License number
North Carolina A2736412
Issued Date
Mar 2017
Expiration Date
Mar 2019
Category
Airmen
Type
Authorized Aircraft Instructor
Address
Address
5101 Kemmont Dr, Durham, NC 27713
Professional information
Methods For The Identification Of Inhibitors Of Threonine Synthase As Antibiotics
US Patent:
6806060, Oct 19, 2004
Filed:
Dec 7, 2001
Appl. No.:
10/011106
Inventors:
Sheryl Frank - Durham NC
Blaise Darveaux - Hillsborough NC
Sanjoy Mahanty - Chapel Hill NC
Ryan Heiniger - Raleigh NC
Amy Skalchunes - Raleigh NC
Huaqin Pan - Apex NC
Rex Tarpey - Apex NC
Jeffrey Shuster - Chapel Hill NC
Matthew M. Tanzer - Durham NC
Lisbeth Hamer - Durham NC
Kiichi Adachi - Durham NC
Todd DeZwaan - Apex NC
Sze-Chung Lo - Durham NC
Blaise Darveaux - Hillsborough NC
Sanjoy Mahanty - Chapel Hill NC
Ryan Heiniger - Raleigh NC
Amy Skalchunes - Raleigh NC
Huaqin Pan - Apex NC
Rex Tarpey - Apex NC
Jeffrey Shuster - Chapel Hill NC
Matthew M. Tanzer - Durham NC
Lisbeth Hamer - Durham NC
Kiichi Adachi - Durham NC
Todd DeZwaan - Apex NC
Sze-Chung Lo - Durham NC
Assignee:
Icoria, Inc. - Research Triangle Park NC
International Classification:
C12Q 118
US Classification:
435 32, 435 29, 435 24, 435 23, 435 4
Abstract:
The present inventors have discovered that Threonine synthase is essential for fungal pathogenicity. Specifically, the inhibition of Threonine synthase gene expression in fungi results in no signs of successful infection or lesions. Thus, Threonine synthase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit Threonine synthase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.
Methods For The Identification Of Inhibitors Of 3-Isopropylmalate Dehydratase As Antibiotics
US Patent:
6733963, May 11, 2004
Filed:
Dec 6, 2001
Appl. No.:
10/010227
Inventors:
Lisbeth Hamer - Durham NC
Kiichi Adachi - Durham NC
Todd DeZwaan - Apex NC
Sze-Chung Lo - Durham NC
Sheryl Frank - Durham NC
Blaise Darveaux - Hillsborough NC
Sanjoy Mahanty - Chapel Hill NC
Ryan Heiniger - Raleigh NC
Amy Skalchunes - Raleigh NC
Huaqin Pan - Apex NC
Rex Tarpey - Apex NC
Jeffrey Shuster - Chapel Hill NC
Matthew M. Tanzer - Durham NC
Kiichi Adachi - Durham NC
Todd DeZwaan - Apex NC
Sze-Chung Lo - Durham NC
Sheryl Frank - Durham NC
Blaise Darveaux - Hillsborough NC
Sanjoy Mahanty - Chapel Hill NC
Ryan Heiniger - Raleigh NC
Amy Skalchunes - Raleigh NC
Huaqin Pan - Apex NC
Rex Tarpey - Apex NC
Jeffrey Shuster - Chapel Hill NC
Matthew M. Tanzer - Durham NC
Assignee:
Paradigm Genetics, Inc. - Research Triangle Park NC
International Classification:
C12Q 100
US Classification:
435 4, 435 691, 4352522, 514601, 514603, 514924, 536 231, 536 237
Abstract:
The present inventors have discovered that 3-Isopropylmalate dehydratase is essential for fungal pathogenicity. Specifically, the inhibition of 3-Isopropylmalate dehydratase gene expression in fungi results in no signs of successful infection or lesions. Thus, 3-Isopropylmalate dehydratase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit 3-Isopropylmalate dehydratase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.
Methods For The Identification Of Inhibitors Of Histidinol-Phosphate As Antibiotics
US Patent:
6740498, May 25, 2004
Filed:
Dec 6, 2001
Appl. No.:
10/010084
Inventors:
Kiichi Adachi - Durham NC
Todd DeZwaan - Apex NC
Sze-Chung Lo - Durham NC
Sheryl Frank - Durham NC
Blaise Darveaux - Hillsborough NC
Sanjoy Mahanty - Chapel Hill NC
Ryan Heiniger - Raleigh NC
Amy Skalchunes - Raleigh NC
Huaqin Pan - Apex NC
Rex Tarpey - Apex NC
Jeffrey Shuster - Chapel Hill NC
Matthew M. Tanzer - Durham NC
Lisbeth Hamer - Durham NC
Todd DeZwaan - Apex NC
Sze-Chung Lo - Durham NC
Sheryl Frank - Durham NC
Blaise Darveaux - Hillsborough NC
Sanjoy Mahanty - Chapel Hill NC
Ryan Heiniger - Raleigh NC
Amy Skalchunes - Raleigh NC
Huaqin Pan - Apex NC
Rex Tarpey - Apex NC
Jeffrey Shuster - Chapel Hill NC
Matthew M. Tanzer - Durham NC
Lisbeth Hamer - Durham NC
Assignee:
Paradigm Genetics, Inc. - Research Triangle Park NC
International Classification:
C12Q 142
US Classification:
435 21, 435 32
Abstract:
The present inventors have discovered that histidinol-phosphatase is essential for fungal pathogenicity. Specifically, the inhibition of histidinol-phosphatase gene expression in fungi results in small, non-sporulating lesions and reduced pathogenicity. Thus, histidinol-phosphatase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit histidinol-phosphatase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.
Methods For The Identification Of Inhibitors Of Methylenetetrahydrofolate Reductase As Antibiotics
US Patent:
2003022, Dec 11, 2003
Filed:
May 13, 2003
Appl. No.:
10/437334
Inventors:
Amy Skalchunes - Raleigh NC, US
Huaqin Pan - Apex NC, US
Rex Tarpey - Apex NC, US
Jeffrey Shuster - Chapel Hill NC, US
Matthew Tanzer - Durham NC, US
Lisbeth Hamer - Durham NC, US
Kiichi Adachi - Tokyo, JP
M. Todd - Apex NC, US
Sze-Chung Lo - Shun Lee Estate, HK
Sheryl Frank - Durham NC, US
Blaise Darveaux - Hillsborough NC, US
Sanjoy Mahanty - Chapel Hill NC, US
Ryan Heiniger - Raleigh NC, US
Huaqin Pan - Apex NC, US
Rex Tarpey - Apex NC, US
Jeffrey Shuster - Chapel Hill NC, US
Matthew Tanzer - Durham NC, US
Lisbeth Hamer - Durham NC, US
Kiichi Adachi - Tokyo, JP
M. Todd - Apex NC, US
Sze-Chung Lo - Shun Lee Estate, HK
Sheryl Frank - Durham NC, US
Blaise Darveaux - Hillsborough NC, US
Sanjoy Mahanty - Chapel Hill NC, US
Ryan Heiniger - Raleigh NC, US
International Classification:
C12Q001/26, C12Q001/18
US Classification:
435/025000, 435/032000
Abstract:
The present inventors have discovered that Methylenetetrahydrofolate reductase is essential for fungal pathogenicity. Specifically, the inhibition of Methylenetetrahydrofolate reductase gene expression in fungi results in an inability to form lesions and non-pathogenicity. Thus, Methylenetetrahydrofolate reductase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit Methylenetetrahydrofolate reductase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.
Methods For The Identification Of Inhibitors Of Trehalose-6-Phosphate Synthase As Antibiotics
US Patent:
2004014, Jul 29, 2004
Filed:
Nov 7, 2003
Appl. No.:
10/703292
Inventors:
Blaise Darveaux - Hillsborough NC, US
Sanjoy Mahanty - Chapel Hill NC, US
Ryan Heiniger - Raleigh NC, US
Amy Covington - Raleigh NC, US
Huaqin Pan - Apex NC, US
Rex Tarpey - Apex NC, US
Jeffrey Shuster - Chapel Hill NC, US
Matthew Tanzer - Durham NC, US
Lisbeth Hamer - Durham NC, US
Kiichi Adachi - Tokyo, JP
Todd DeZwaan - Apex NC, US
Sze-Chung Lo - Shun Lee Estate, HK
Sheryl Frank - Durham NC, US
Sanjoy Mahanty - Chapel Hill NC, US
Ryan Heiniger - Raleigh NC, US
Amy Covington - Raleigh NC, US
Huaqin Pan - Apex NC, US
Rex Tarpey - Apex NC, US
Jeffrey Shuster - Chapel Hill NC, US
Matthew Tanzer - Durham NC, US
Lisbeth Hamer - Durham NC, US
Kiichi Adachi - Tokyo, JP
Todd DeZwaan - Apex NC, US
Sze-Chung Lo - Shun Lee Estate, HK
Sheryl Frank - Durham NC, US
International Classification:
C12Q001/48
US Classification:
435/015000
Abstract:
The present inventors have discovered that Trehalose-6-Phosphate Synthase is essential for normal fungal pathogenicity. Specifically, the inhibition of Trehalose-6-Phosphate Synthase gene expression in fungi results in reduced pathogenicity (i.e. smaller, non-viable lesions). Thus, Trehalose-6-Phosphate Synthase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit Trehalose-6-Phosphate Synthase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.
Methods For The Identification Of Inhibitors Of Pyrroline-5-Carboxylate Reductase As Antibiotics
US Patent:
2004024, Dec 9, 2004
Filed:
Dec 19, 2003
Appl. No.:
10/742541
Inventors:
Matthew Tanzer - Durham NC, US
Jeffrey Shuster - Chapel Hill NC, US
Todd DeZwaan - Apex NC, US
Sheryl Frank - Durham NC, US
Ryan Heiniger - Raleigh NC, US
Amy Covington - Raleigh NC, US
Lisbeth Hamer - Durham NC, US
Kiichi Adachi - Tokyo, JP
Sze-Chung Lo - Shun Lee Estate, HK
Blaise Darveaux - Hillsborough NC, US
Sanjoy Mahanty - Chapel Hill NC, US
Huaqin Pan - Apex NC, US
Rex Tarpey - Apex NC, US
Jeffrey Shuster - Chapel Hill NC, US
Todd DeZwaan - Apex NC, US
Sheryl Frank - Durham NC, US
Ryan Heiniger - Raleigh NC, US
Amy Covington - Raleigh NC, US
Lisbeth Hamer - Durham NC, US
Kiichi Adachi - Tokyo, JP
Sze-Chung Lo - Shun Lee Estate, HK
Blaise Darveaux - Hillsborough NC, US
Sanjoy Mahanty - Chapel Hill NC, US
Huaqin Pan - Apex NC, US
Rex Tarpey - Apex NC, US
International Classification:
A61K038/00, C12Q001/18
US Classification:
514/002000, 435/032000
Abstract:
The present inventors have discovered that pyrroline-5-carboxylate reductase is essential for normal fungal pathogenicity. Specifically, the inhibition of pyrroline-5-carboxylate reductase gene expression in fungi results in drastically reduced pathogenicity. Thus, pyrroline-5-carboxylate reductase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit pyrroline-5-carboxylate reductase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.
Methods For The Identification Of Inhibitors Of Histidinol Dehydrogenase As Antibiotics
US Patent:
2005022, Oct 13, 2005
Filed:
Mar 10, 2005
Appl. No.:
11/076770
Inventors:
Matthew Tanzer - Durham NC, US
Jeffrey Shuster - Chapel Hill NC, US
Lisbeth Hamer - Durham NC, US
Kiichi Adachi - Osaka, JP
Todd DeZwaan - Apex NC, US
Sze-Chung Lo - Hong Kong, CN
Blaise Darveaux - Hillsborough NC, US
Sheryl Frank - Durham NC, US
Ryan Heiniger - Holly Springs NC, US
Sanjoy Mahanty - Chapel Hill NC, US
Huaqin Pan - Apex NC, US
Amy Covington - Raleigh NC, US
Rex Tarpey - Apex NC, US
Jeffrey Shuster - Chapel Hill NC, US
Lisbeth Hamer - Durham NC, US
Kiichi Adachi - Osaka, JP
Todd DeZwaan - Apex NC, US
Sze-Chung Lo - Hong Kong, CN
Blaise Darveaux - Hillsborough NC, US
Sheryl Frank - Durham NC, US
Ryan Heiniger - Holly Springs NC, US
Sanjoy Mahanty - Chapel Hill NC, US
Huaqin Pan - Apex NC, US
Amy Covington - Raleigh NC, US
Rex Tarpey - Apex NC, US
International Classification:
C12Q001/68, G01N033/53, G01N033/569, C12Q001/18
US Classification:
435007310, 435032000
Abstract:
The present inventors have discovered that a histidinol dehydrogenase (HIS4) is essential for normal fungal pathogenicity, Specifically, the inhibition of HIS4 gene expression in severely reduces the pathogenicity of the fungus. Thus, HIS4 is useful as a target for the identification of antibiotics, preferably fungicides. Accordingly, the present invention provides methods for the identification of compounds that inhibit HIS4 expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably fungicides.
Methods For The Identification Of Inhibitors Of Adenylosuccinate Synthase As Antibiotics
US Patent:
2005022, Oct 13, 2005
Filed:
Jan 13, 2005
Appl. No.:
11/034798
Inventors:
Matthew Tanzer - Durham NC, US
Jeffrey Shuster - Chapel Hill NC, US
Lisbeth Hamer - Durham NC, US
Todd DeZwaan - Apex NC, US
Sze-Chung Lo - Hong Kong, HK
Blaise Darveaux - Hillsborough NC, US
Sheryl Frank - Durham NC, US
Ryan Heiniger - Holly Springs NC, US
Sanjoy Mahanty - Chapel Hill NC, US
Huaqin Pan - Apex NC, US
Amy Covington - Raleigh NC, US
Rex Tarpey - Apex NC, US
Kiichi Adachi - Osaka, JP
Jeffrey Shuster - Chapel Hill NC, US
Lisbeth Hamer - Durham NC, US
Todd DeZwaan - Apex NC, US
Sze-Chung Lo - Hong Kong, HK
Blaise Darveaux - Hillsborough NC, US
Sheryl Frank - Durham NC, US
Ryan Heiniger - Holly Springs NC, US
Sanjoy Mahanty - Chapel Hill NC, US
Huaqin Pan - Apex NC, US
Amy Covington - Raleigh NC, US
Rex Tarpey - Apex NC, US
Kiichi Adachi - Osaka, JP
International Classification:
C12Q001/48, C12Q001/18
US Classification:
435015000, 435032000
Abstract:
The present inventors have discovered that adenylosuccinate synthase is essential for normal fungal pathogenicity. Specifically, the inhibition of adenylosuccinate synthase gene expression in fungi results in drastically reduced pathogenicity. Thus, adenylosuccinate synthase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit adenylosuccinate synthase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.
Methods For The Identification Of Inhibitors Of Cyclic Nucleotide Phosphodiesterase As Antibiotics
US Patent:
2005023, Oct 20, 2005
Filed:
Jan 24, 2005
Appl. No.:
11/041553
Inventors:
Matthew Tanzer - Durham NC, US
Jeffrey Shuster - Chapel Hill NC, US
Lisbeth Hamer - Durham NC, US
Kiichi Adachi - Osaka, JP
Todd DeZwaan - Apex NC, US
Sze-Chung Lo - Hong Kong, CN
Blaise Darveaux - Hillsborough NC, US
Sheryl Frank - Durham NC, US
Ryan Heiniger - Holly Springs NC, US
Sanjoy Mahanty - Chapel Hill NC, US
Huaqin Pan - Apex NC, US
Amy Covington - Raleigh NC, US
Rex Tarpey - Apex NC, US
Jeffrey Shuster - Chapel Hill NC, US
Lisbeth Hamer - Durham NC, US
Kiichi Adachi - Osaka, JP
Todd DeZwaan - Apex NC, US
Sze-Chung Lo - Hong Kong, CN
Blaise Darveaux - Hillsborough NC, US
Sheryl Frank - Durham NC, US
Ryan Heiniger - Holly Springs NC, US
Sanjoy Mahanty - Chapel Hill NC, US
Huaqin Pan - Apex NC, US
Amy Covington - Raleigh NC, US
Rex Tarpey - Apex NC, US
International Classification:
C12Q001/42, C12Q001/18
US Classification:
435021000, 435032000
Abstract:
The present inventors have discovered that a cyclic nucleotide phosphodiesterase is essential for normal fungal pathogenicity. Specifically, the inhibition of PDE2 gene expression in severely reduces the pathogenicity of the fungus. Thus, PDE2 is useful as a target for the identification of antibiotics, preferably fungicides. Accordingly, the present invention provides methods for the identification of compounds that inhibit PDE2 expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably fungicides.
Methods For The Identification Of Inhibitors Of Ornithine Carbamoyltransferase As Antibiotics
US Patent:
2005001, Jan 27, 2005
Filed:
May 20, 2004
Appl. No.:
10/849985
Inventors:
Matthew Tanzer - Durham NC, US
Lisbeth Hamer - Durham NC, US
Kiichi Adachi - Osaka, JP
Todd DeZwaan - Apex NC, US
Sze-Chung Lo - Shun Lee Estate, HK
Blaise Darveaux - Hillsborough NC, US
Sheryl Frank - Durham NC, US
Ryan Heiniger - Raleigh NC, US
Sanjoy Mahanty - Chapel Hill NC, US
Huaqin Pan - Apex NC, US
Amy Covington - Raleigh NC, US
Rex Tarpey - Apex NC, US
Jeffrey Shuster - Chapel Hill NC, US
Lisbeth Hamer - Durham NC, US
Kiichi Adachi - Osaka, JP
Todd DeZwaan - Apex NC, US
Sze-Chung Lo - Shun Lee Estate, HK
Blaise Darveaux - Hillsborough NC, US
Sheryl Frank - Durham NC, US
Ryan Heiniger - Raleigh NC, US
Sanjoy Mahanty - Chapel Hill NC, US
Huaqin Pan - Apex NC, US
Amy Covington - Raleigh NC, US
Rex Tarpey - Apex NC, US
Jeffrey Shuster - Chapel Hill NC, US
International Classification:
C12Q001/68, G01N033/53, G01N033/569
US Classification:
435007310
Abstract:
The present inventors have discovered that ornithine carbamoyltransferase is essential for normal fungal pathogenicity. Specifically, the inhibition of ornithine carbamoyltransferase gene expression in fungi eliminates pathogenicity. Thus, ornithine carbamoyltransferase is useful as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit ornithine carbamoyltransferase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.