MARVIN SAVIDGE REITZ, JR
Pilots at Bowie Ml Rd, Rockville, MD

License number

Maryland C1027824

Professional information

Genes Of Kaposi's Sarcoma Associated Herpesvirus

US Patent:

6264958, Jul 24, 2001

Filed:

Nov 23, 1999

Appl. No.:

9/230637

Inventors:

Gary S. Hayward - Baltimore MD
John Nicholas - Towson MD
Marvin R. Reitz - Derwood MD
J. Marie Hardwick - Baltimore MD

Assignee:

The Johns Hopkins University - Baltimore MD

International Classification:

A61K 39245, A61K 3912, C12P 1934

US Classification:

4242291

Abstract:

A human gamma herpesviris genome known as Kaposi sarcoma associated herpesvirus (KSHV) or human herpesvirus 8 (HHV-8) is present in virtually all AIDS and non-AIDS Kaposi's sarcoma (KS) lesions, as well as in body cavity based lymphomas (BCBL), Multiple myeloma, and in multicentric Casdeman's disease. Isolation and DNA sequencing of a 17-kb segment encompassing a HHV-8 divergent locus (DL-B) between ORF11 and ORF17 revealed the presence of nine viral ORFs with gene products related to cellular proteins. These include the complete thymidylate synthase (TS) gene and a dihydrofolate reductase (DHFR) gene, four cytokine genes (vIL6, vMIP-1A, vMIP-1B and BCK) that have not previously been found to be encoded by a virus, and a Bcl2 homologue. This region in HHV-8 also contains the T1. 1 abundant lytic cycle nuclear RNA gene and encompasses two genes (or exons) encoding proteins with C4HC3 zinc finger domains of the PHD/LAP subtype.

Molecular Clones Of Hiv-1 Viral Strains Mh-St1 And Ba-L, And Uses Thereof

US Patent:

5576000, Nov 19, 1996

Filed:

Feb 15, 1995

Appl. No.:

8/388809

Inventors:

Marvin S. Reitz - Derwood MD
Genoveffa Franchini - Washington DC
Phillip D. Markham - Rockville MD
Robert C. Gallo - Bethesda MD
Franco C. Lori - Bethesda MD
Mikulas Popovic - Bethesda MD
Suzanne Gartner - N. Potomac MD

Assignee:

The United States of America as represented by the Department of Health
and Human Services - Washington DC

International Classification:

A61K 3921

US Classification:

4241881

Abstract:

The present invention relates to the HIV-1 strains MN-ST1 and BA-L which are typical United States HIV-1 isotypes. The present invention relates to DNA segments encoding the envelope protein of MN-ST 1 or BA-L, to DNA constructs containing such DNA segments and to host cells transformed with such constructs. The viral isolates and envelope proteins of the present invention are of value for use in vaccines and bioassays for the detection of HIV-1 infection in biological samples, such as blood bank samples.

Molecular Clones Of Hiv-1 Viral Strains Mn-St1 And Ba-L And Uses Thereof

US Patent:

5420030, May 30, 1995

Filed:

Feb 25, 1993

Appl. No.:

8/022835

Inventors:

Assignee:

The United States of America as represented by the Department of Health
and Human Services - Washington DC

International Classification:

C12N 700

US Classification:

4352351

Abstract:

The present invention relates to the HIV-1 strains MN-ST1 and BA-L which are typical United States HIV-1 isotypes. The present invention relates to DNA segments encoding the envelope protein of MN-ST1 or BA-L, to DNA constructs containing such DNA segments and to host cells transformed with such constructs. The viral isolates and envelope proteins of the present invention are of value for use in vaccines and bioassays for the detection of HIV-1 infection in biological samples, such as blood bank samples.

Molecular Clones Of Hiv-1 Viral Strains Mn-St1 And Ba-L, And Uses Thereof

US Patent:

5869313, Feb 9, 1999

Filed:

May 14, 1996

Appl. No.:

8/647714

Inventors:

Assignee:

The United States of America as represented by the Department of Health
and Human Services - Washington DC

International Classification:

C12N 700

US Classification:

435 351

Abstract:

The present invention relates to the HIV-1 strains MN-ST1 and BA-L which are typical United States HIV-1 isotypes. The present invention relates to DNA segments encoding the envelope protein of MN-ST1 or BA-L, to DNA constructs containing such DNA segments and to host cells transformed with such constructs. The viral isolates and envelope proteins of the present invention are of value for use in vaccines and bioassays for the detection of HIV-1 infection in biological samples, such as blood bank samples.