MARK R BRINKER
Medical Practice at Main, Houston, TX

5618286, Apr 8, 1997

Apr 20, 1995

8/425609

Mark Brinker - Houston TX

A61B 1756

606 60

An antibiotic eluding intramedullary nail apparatus for use in the intramedullary fixation of fractured long bones, such as femurs, tibias, fibulas, humeri, ulnas and radii, as well as other orthopedic and bone reconstructive procedures, and, in particular fractures associated with an open wound exposing the soft tissue and medullary canal of the fractured bone to bacteria and other infectious micro-organisms. The apparatus includes an intramedullary nail to which is secured an antibiotic impregnated carrier compound, the apparatus being surgically insertable within the medullary canal of a fractured bone using conventional intramedullary nailing techniques thus providing a sustained localized release of antibiotic agents in bactericidial concentrations, and/or chemotherapeutic agents for bone tumors, directly within the medullary canal of the fractured bone and thereby serving to permit the use of intramedullary nailing to repair injuries which may be otherwise contraindicated due to the risk of deep wound and/or bone infections and/or bone tumors.

2007005, Mar 8, 2007

Aug 1, 2006

11/497077

Mark Brinker - Houston TX, US

A61B 17/00

606054000

A system is disclosed for externally repairing fractured bones and facilitating alignment of displaced fractured bone segments without requiring use of an external ring fixator system and tension wires. The system comprises at least one panel member having a plurality of apertures extending from a first side to a second side of the panel member. At least two pin carriers are capable of being inserted into at least two of the plurality of apertures in the at least one panel member, the pin carriers, upon insertion into one of the plurality of apertures in the panel member, being longitudinally fixed relative to the aperture, but capable of rotation within the aperture. At least two half-pins are capable of insertion into the a pin carrier, following insertion of the one pin carrier into one of the plurality of apertures provided in the panel member, toward subsequent securement to a fractured bone segment. Rotation of a pin carrier causes an associated half-pin inserted therein to move longitudinally with respect to the panel member to, in turn, reposition the fractured bone segment affixed to the half-pin, relative to the panel member.

2011009, Apr 21, 2011

Nov 13, 2008

12/742831

Mark S.F. Clarke - Houston TX, US
Mark Brinker - Houston TX, US
Alamelu Sundaresan - Sugarland TX, US

OSTEOSPHERE, LLC - Houston TX

C12N 5/077

435 11, 435366

The present disclosure provides methods for producing human osteogenic cell lines in which HLA Class I expression is absent or reduced. The resulting osteogenic cells can then be used, for example, to form mineralized three-dimensional bone constructs which can be used, for example, in bone grafting procedures. The lack of HLA Class I expression in the cells of the mineralized three-dimensional bone constructs reduces or eliminates the potential for host-graft rejection.

2011008, Apr 14, 2011

Nov 14, 2008

12/742810

Mark S.F. Clarke - Houston TX, US
Mark Brinker - Houston TX, US
Alamelu Sundaresan - Sugarland TX, US

OSTEOSPHERE, LLC - Houston TX

A61K 9/00, C12N 5/077, A61P 19/00

424423, 435395

The present disclosure provides ex vivo-derived human demineralized bone matrix. The bone matrix is produced using mineralized three-dimensional bone constructs. The bone constructs are obtained by culturing osteoblasts and osteoclast precursors under randomized gravity vector conditions. Preferably, the randomized gravity vector conditions are obtained using a low shear stress rotating bioreactor, such as a High Aspect Ratio Vessel (HARV) culture system. The ex vivo-derived human demineralized bone matrix of the disclosure can be used in, for example, orthopedic and periodontal procedures.

2011008, Apr 7, 2011

Feb 2, 2009

12/865568

Mark S.F. Clarke - Houston TX, US
Mark R. Brinker - Houston TX, US
Alamelu Sundaresan - Sugarland TX, US

OSTEOSPHERE, LLC - Houston TX

A61F 2/28, C12Q 1/02, C12N 5/071

623 1611, 435 29, 435394

The present disclosure provides ex vivo-derived mineralized three-dimensional bone constructs. The bone constructs are obtained by culturing osteoblasts under randomized gravity vector conditions. Preferably, the randomized gravity vector conditions are obtained using a low shear stress rotating bioreactor, such as a High Aspect Ratio Vessel (HARV) culture system. The bone constructs of the disclosure have utility in physiological studies of bone formation and bone function, in drug discovery, and in orthopedics.

2011008, Apr 7, 2011

Nov 13, 2008

12/742814

Mark Brinker - Houston TX, US
Mark S.F. Clarke - Houston TX, US
Alamelu Sundaresan - Sugarland TX, US

OSTEOSPHERE, LLC - Houston TX

C12P 21/00

435 703

The present disclosure provides methods for producing Bone Morphogenetic Proteins (BMPs). The BMPs are produced using ex vivo-derived mineralized three-dimensional bone constructs of varying degrees of maturity and mineralization. The bone constructs are obtained by culturing osteoblasts and osteoclast precursors under randomized gravity vector conditions whereupon the bone constructs secrete BMPs into the culture medium. Culture medium is periodically removed from the bone construct culture, and the BMPs are purified from the removed culture medium.