MARK JOHN LYNCH
Pilots at Lyle Dr, Madison, CT
License number
Connecticut A2233039
Category
Airmen
Type
Authorized Aircraft Instructor
Address
Address
16 Lyle Dr, Madison, CT 06443
Professional information
Process For Preparing Quinazoline Rho-Kinase Inhibitors And Intermediates Thereof
US Patent:
7645878, Jan 12, 2010
Filed:
Sep 24, 2002
Appl. No.:
10/252369
Inventors:
Donald Bankston - Wallingford CT, US
Davoud Asgari - Plainsboro NJ, US
Jianxing Shao - Cheshire CT, US
Uday Khire - Hamden CT, US
Chunguang Wang - Hamden CT, US
Barry Hart - Woodbridge CT, US
Stephen Boyer - Fairfield CT, US
Olaf Weber - Woodbridge CT, US
Mark Lynch - Madison CT, US
Davoud Asgari - Plainsboro NJ, US
Jianxing Shao - Cheshire CT, US
Uday Khire - Hamden CT, US
Chunguang Wang - Hamden CT, US
Barry Hart - Woodbridge CT, US
Stephen Boyer - Fairfield CT, US
Olaf Weber - Woodbridge CT, US
Mark Lynch - Madison CT, US
Assignee:
Bayer Healthcare LLC - Tarrytown NY
International Classification:
C07D 239/94
US Classification:
544284, 544 28, 544 79
Abstract:
A process for the preparation of various quinazoline compounds which are useful as Rho-Kinase inhibitors, and thus having utility in the treatment of hypertension and other indications.
Substituted Thieno[3,2-D]Pyrimidines As Rho Kinase Inhibitors
US Patent:
7648986, Jan 19, 2010
Filed:
Apr 9, 2007
Appl. No.:
11/733045
Inventors:
Dhanapalan Nagarathnam - Bethany CT, US
Uday Khire - Hamden CT, US
Davoud Asgari - Plainsboro NJ, US
Jianxing Shao - Cheshire CT, US
Chunguang Wang - Hamden CT, US
Barry Hart - Mountain View CA, US
Olaf Weber - Woodbridge CT, US
Mark Lynch - Madison CT, US
Lei Zhang - Hamden CT, US
Lei Wang - New Haven CT, US
Uday Khire - Hamden CT, US
Davoud Asgari - Plainsboro NJ, US
Jianxing Shao - Cheshire CT, US
Chunguang Wang - Hamden CT, US
Barry Hart - Mountain View CA, US
Olaf Weber - Woodbridge CT, US
Mark Lynch - Madison CT, US
Lei Zhang - Hamden CT, US
Lei Wang - New Haven CT, US
Assignee:
Bayer Healthcare LLC - Tarrytown NY
International Classification:
C07D 495/04, C07D 251/16, C07D 413/10, A61K 31/519, A61K 31/5377, A61K 31/53, A61K 31/497, A61K 31/496, A61K 31/498, A61P 9/12, A61P 9/10, A61P 35/04, A61P 11/06, C07D 401/12, C07D 401/14
US Classification:
5142342, 51425216, 514245, 5142601, 51425505, 51426411, 544117, 544211, 544278, 544284
Abstract:
Disclosed are compounds and derivatives thereof their synthesis, and their use as Rho-kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e. g. , coronary heart disease.
Diaryl Ureas With Kinase Inhibiting Activity
US Patent:
2007002, Jan 25, 2007
Filed:
May 19, 2004
Appl. No.:
10/571100
Inventors:
Scott Wilhelm - Orange CT, US
Jacques Dumas - Bethany CT, US
Gaetan Ladouceur - Guilford CT, US
Mark Lynch - Madison CT, US
William Scott - Guilford CT, US
Jacques Dumas - Bethany CT, US
Gaetan Ladouceur - Guilford CT, US
Mark Lynch - Madison CT, US
William Scott - Guilford CT, US
International Classification:
G01N 33/567, C12Q 1/37, A61K 31/165, A61K 31/16, A61K 31/66
US Classification:
435007210, 435023000, 514114000, 514616000
Abstract:
The present invention provides methods of using aryl ureas to treat diseases and conditions associated with signal transduction pathways comprising at least one of raf, VEGFR, PDGFR, p38 and/or FLT-3. The present invention also provides compositions and methods for identifying conditions and diseases which can be modulated with compounds of the present invention. These methods facilitate the selection of subjects who can be efficiently treated with compounds of the present invention. Additionally, the invention provides methods for monitoring subjects who have been administered a compound of the present invention.
Process For Preparing Quinazoline Rho-Kinase Inhibitors And Intermediates Thereof
US Patent:
2010012, May 20, 2010
Filed:
Nov 17, 2009
Appl. No.:
12/619884
Inventors:
Donald BANKSTON - Wallingford CT, US
Davoud Asgari - Plainsboro NJ, US
Jianxing Shao - Cheshire CT, US
Uday Khire - Hamden CT, US
Chunguang Wang - Hamden CT, US
Barry Hart - Woodbridge CT, US
Stephen Boyer - Fairfield CT, US
Olaf Weber - Woodbridge CT, US
Mark Lynch - Madison CT, US
Davoud Asgari - Plainsboro NJ, US
Jianxing Shao - Cheshire CT, US
Uday Khire - Hamden CT, US
Chunguang Wang - Hamden CT, US
Barry Hart - Woodbridge CT, US
Stephen Boyer - Fairfield CT, US
Olaf Weber - Woodbridge CT, US
Mark Lynch - Madison CT, US
International Classification:
C07D 403/12, C07D 239/91, C07D 405/14, C07D 239/93
US Classification:
544284, 544289
Abstract:
A process for the preparation of various quinazoline compounds which are useful as Rho-Kinase inhibitors, and thus having utility in the treatment of hypertension and other indications.
Diaryl Ureas For Diseases Mediated By Pdgfr
US Patent:
2005005, Mar 17, 2005
Filed:
May 19, 2004
Appl. No.:
10/848567
Inventors:
Scott Wilhelm - Orange CT, US
Jacques Dumas - Bethany CT, US
Gaetan Ladouceur - Guilford CT, US
Mark Lynch - Madison CT, US
William Scott - Guilford CT, US
Jacques Dumas - Bethany CT, US
Gaetan Ladouceur - Guilford CT, US
Mark Lynch - Madison CT, US
William Scott - Guilford CT, US
International Classification:
A61K031/443
US Classification:
514338000
Abstract:
The present invention provides methods for treating and/or preventing conditions and diseases in humans and other mammals that are associated with and/or mediated by signal transduction pathways comprising platelet-derived growth factor receptor (PDGFR) by administering diaryl ureas of Formula I. The present invention also provides devices and methods for treating, ameliorating, preventing, or modulating restenosis following angioplastic surgery or other invasive procedures that affect or injure the vascular system, and graft rejection following transplantation of a donor tissue into a host, where a stent or other omplantable device comprises an effective amount of diaryl ureas of Formula I.
Rho-Kinase Inhibitors
US Patent:
2006014, Jun 29, 2006
Filed:
Feb 16, 2006
Appl. No.:
11/354977
Inventors:
Davoud Asgari - Hamden CT, US
Jianxing Shao - Cheshire CT, US
Uday Khire - Hamden CT, US
Chunguang Wang - Hamden CT, US
Barry Hart - Woodbridge CT, US
Stephen Boyer - Fairfield CT, US
Olaf Weber - Woodbridge CT, US
Mark Lynch - Madison CT, US
Jianxing Shao - Cheshire CT, US
Uday Khire - Hamden CT, US
Chunguang Wang - Hamden CT, US
Barry Hart - Woodbridge CT, US
Stephen Boyer - Fairfield CT, US
Olaf Weber - Woodbridge CT, US
Mark Lynch - Madison CT, US
International Classification:
A61K 31/517, A61K 31/4709, C07D 403/02
US Classification:
514266200, 514312000, 544284000, 546153000
Abstract:
Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.
Rho-Kinase Inhibitors
US Patent:
2010013, Jun 3, 2010
Filed:
Feb 2, 2010
Appl. No.:
12/698386
Inventors:
Davoud Asgari - Hamden CT, US
Jianxing Shao - Cheshire CT, US
Uday Khire - Hamden CT, US
Chunguang Wang - Hamden CT, US
Barry Hart - Woodbridge CT, US
Stephen Boyer - Fairfield CT, US
Olaf Weber - Woodbridge CT, US
Mark Lynch - Madison CT, US
Jianxing Shao - Cheshire CT, US
Uday Khire - Hamden CT, US
Chunguang Wang - Hamden CT, US
Barry Hart - Woodbridge CT, US
Stephen Boyer - Fairfield CT, US
Olaf Weber - Woodbridge CT, US
Mark Lynch - Madison CT, US
International Classification:
A61K 31/517, C07D 403/12, C07D 405/14, C07D 409/14, C07D 413/14, C07D 403/14, A61P 9/10, A61P 25/00, A61P 35/00
US Classification:
514249, 544284, 51426623
Abstract:
Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.
Rho-Kinase Inhibitors
US Patent:
2003012, Jul 3, 2003
Filed:
Mar 22, 2002
Appl. No.:
10/103566
Inventors:
Davoud Asgari - Hamden CT, US
Jianxing Shao - Cheshire CT, US
Uday Khire - Hamden CT, US
Chunguang Wang - Hamden CT, US
Barry Hart - Woodbridge CT, US
Stephen Boyer - Fairfield CT, US
Olaf Weber - Woodbridge CT, US
Mark Lynch - Madison CT, US
Jianxing Shao - Cheshire CT, US
Uday Khire - Hamden CT, US
Chunguang Wang - Hamden CT, US
Barry Hart - Woodbridge CT, US
Stephen Boyer - Fairfield CT, US
Olaf Weber - Woodbridge CT, US
Mark Lynch - Madison CT, US
Assignee:
BAYER CORPORATION - Pittsburgh PA
International Classification:
A61K031/517, A61K031/4709, C 07D 4 3/02, C 07D 4 1/02
US Classification:
514/266200, 514/313000, 514/266230, 544/284000, 546/159000
Abstract:
Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.
Rho-Kinase Inhibitors
US Patent:
2010021, Aug 26, 2010
Filed:
Jan 15, 2010
Appl. No.:
12/688428
Inventors:
Dhanapalan NAGARATHNAM - Bethany CT, US
Uday Khire - Hamden CT, US
Davoud Asgari - Plainsboro NJ, US
Jianxing Shao - Cheshire CT, US
Chunguang Wang - Hamden CT, US
Barry Hart - Mountain View CA, US
Olaf Weber - Woodbridge CT, US
Mark Lynch - Madison CT, US
Lei Zhang - Hamden CT, US
Lei Wang - New Haven CT, US
Uday Khire - Hamden CT, US
Davoud Asgari - Plainsboro NJ, US
Jianxing Shao - Cheshire CT, US
Chunguang Wang - Hamden CT, US
Barry Hart - Mountain View CA, US
Olaf Weber - Woodbridge CT, US
Mark Lynch - Madison CT, US
Lei Zhang - Hamden CT, US
Lei Wang - New Haven CT, US
International Classification:
A61K 31/519, C07D 495/04, A61K 31/5377, A61K 31/53, C07D 513/04, A61P 9/12, A61P 9/10, A61P 15/10
US Classification:
5142342, 544278, 5142601, 544117, 51425216, 514249, 51426411, 544212, 514245
Abstract:
Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.
Rho-Kinase Inhibitors
US Patent:
2004001, Jan 22, 2004
Filed:
Jan 10, 2003
Appl. No.:
10/339393
Inventors:
Dhanapalan Nagarathnam - Bethany CT, US
Uday Khire - Hamden CT, US
Davoud Asgari - Plainsboro NJ, US
Jianxing Shao - Cheshire CT, US
Chunguang Wang - Hamden CT, US
Barry Hart - Mountain View CA, US
Olaf Weber - Woodbridge CT, US
Mark Lynch - Madison CT, US
Lei Zhang - Hamden CT, US
Lei Wang - New Haven CT, US
Uday Khire - Hamden CT, US
Davoud Asgari - Plainsboro NJ, US
Jianxing Shao - Cheshire CT, US
Chunguang Wang - Hamden CT, US
Barry Hart - Mountain View CA, US
Olaf Weber - Woodbridge CT, US
Mark Lynch - Madison CT, US
Lei Zhang - Hamden CT, US
Lei Wang - New Haven CT, US
International Classification:
A61K031/5377, A61K031/519, A61K031/517, C07D491/02, C07D498/02
US Classification:
514/234500, 514/260100, 514/255050, 514/266220, 514/266210, 514/266200, 544/284000, 544/279000, 544/280000, 544/116000
Abstract:
Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.