MARK C FISHMAN, M.D.
Osteopathic Medicine at Massachusetts Ave, Cambridge, MA
License number
Massachusetts 42783
Category
Osteopathic Medicine
Type
Internal Medicine
Address
Address
2
250 Massachusetts Ave, Cambridge, MA 02139
43 Kenwood Ave, Newton, MA 02459
43 Kenwood Ave, Newton, MA 02459
Phone
(617) 871-3400
Personal information
See more information about MARK C FISHMAN at radaris.comName
Address
Phone
43 Kenwood Ave, Newton Center, MA 02459
51 Grandview Rd, Arlington, MA 02476
135 Saint Paul St #1, Brookline, MA 02446
135 Saint Paul St APT 1, Brookline, MA 02446
29 Lynbrook Rd, Southborough, MA 01772
Organization information
See more information about MARK C FISHMAN at bizstanding.comNovartis Institues-Bio Medical - Mark C Fishman MD
250 Massachusetts Ave, Cambridge, MA 02139
Categories:
Internal Medicine Physicians & Surgeons
Phone:
(617) 871-8000 (Phone)
Dr. Mark C. Fishman, MD
250 Massachusetts Ave, Cambridge, MA 02139
Industry:
Medical Doctor's Office
Principal:
Mark C. Fishman (Principal)
Professional information
Endothelial Nos Transgenic Animals And Methods Of Use
US Patent:
6630347, Oct 7, 2003
Filed:
Oct 20, 2000
Appl. No.:
09/692056
Inventors:
Paul L. Huang - Boston MA
Mark C. Fishman - Newton Center MA
Michael A. Moskowitz - Belmont MA
Mark C. Fishman - Newton Center MA
Michael A. Moskowitz - Belmont MA
Assignee:
The General Hospital Corporation - Boston MA
International Classification:
C12N 500
US Classification:
435325, 435354, 435366, 435368, 435371, 435372, 435455, 435463
Abstract:
This invention relates to transgenic non-human animals comprising a disrupted endothelial nitric oxide synthase gene. These animals exhibit abnormal wound-healing properties and hypertension. This invention also relates to methods of using the transgenic animals to screen for compounds having a potential therapeutic utility for vascular endothelial disorders, such as hypertension, cerebral ischemia or stroke, atherosclerosis and wound-healing activities. Moreover, this invention also relates to methods of treating a patient suffering from hypertension and wound-healing abnormalities with the compounds identified using the transgenic animals, and methods of making the transgenic animals. A method of treating a wound using nitroglycerin is also provided.
Endothelial Nos Knockout Mice And Methods Of Use
US Patent:
6310270, Oct 30, 2001
Filed:
Mar 14, 1997
Appl. No.:
8/818082
Inventors:
Paul L. Huang - Boston MA
Mark C. Fishman - Newton Center MA
Michael A. Moskowitz - Belmont MA
Mark C. Fishman - Newton Center MA
Michael A. Moskowitz - Belmont MA
Assignee:
The General Hospital Corporation - Boston MA
International Classification:
A01K 6700, A01K 67033, C12N 1500, G01N 3300
US Classification:
800 18
Abstract:
This invention relates to transgenic non-human animals comprising a disrupted endothelial nitric oxide synthase gene. These animals exhibit abnormal wound-healing properties and hypertension. This invention also relates to methods of using the transgenic animals to screen for compounds having a potential therapeutic utility for vascular endothelial disorders, such as hypertension, cerebral ischemia or stroke, atherosclerosis and wound-healing activities. Moreover, this invention also relates to methods of treating a patient suffering from hypertension and wound-healing abnormalities with the compounds identified using the transgenic animals, and methods of making the transgenic animals. A method of treating a wound using nitroglycerin is also provided.
Methods For Diagnosing And Treating Heart Disease
US Patent:
2005006, Mar 24, 2005
Filed:
Oct 1, 2002
Appl. No.:
10/491452
Inventors:
Mark Fishman - Newton Center MA, US
Wolfgang Rottbauer - Regensburg, DE
Wolfgang Rottbauer - Regensburg, DE
International Classification:
C12Q001/68
US Classification:
435006000
Abstract:
The invention provides methods of diagnosing and treating heart diseases and conditions, methods for identifying compounds that can be used to treat or to prevent such diseases and conditions, and methods of using these compounds to treat or to prevent such diseases and conditions. Also provided in the invention are animal model systems that can be used in screening methods.
Gridlock Nucleic Acid Molecules, Polypeptides, And Diagnostic And Therapeutic Methods
US Patent:
6991936, Jan 31, 2006
Filed:
Feb 10, 2003
Appl. No.:
10/364012
Inventors:
Mark C. Fishman - Newton Center MA, US
Tao P. Zhong - Belmont MA, US
Tao P. Zhong - Belmont MA, US
Assignee:
The General Hospital Corporation - Boston MA
International Classification:
C12N 1/00, C12N 15/00, C12N 15/09, C12N 15/63, C12N 15/70
US Classification:
4353201, 530350, 536 231
Abstract:
The invention provides a novel gene, gridlock, and its encoded protein. gridlock plays a role in vascular development and modeling, and a mutation in gridlock has been associated with an aortic arch disease, coarctation. Thus, gridlock nucleic acid molecules and polypeptides can be used in methods of diagnosing, treating, and preventing gridlock-related diseases and conditions, such as aortic arch diseases.
Methods For Diagnosing And Treating Diseases And Conditions Of The Heart Or Digestive System, And Cancer
US Patent:
2005005, Mar 10, 2005
Filed:
Oct 1, 2002
Appl. No.:
10/490913
Inventors:
Mark Fishman - Newton Center MA, US
Wolfgang Rottbauer - Regensburg, DE
Wolfgang Rottbauer - Regensburg, DE
International Classification:
C12Q001/68
US Classification:
435006000
Abstract:
The invention provides methods of diagnosing and treating diseases and conditions of the heart or digestive system and cancer, methods for identifying compounds that can be used to treat or to prevent such diseases and conditions, and methods of using these compounds to treat or to prevent such diseases and conditions. Also provided in the invention are animal model systems that can be used in screening methods.
Compositions And Methods Of Use For Antibodies Of Dickkopf-1
US Patent:
2012002, Jan 26, 2012
Filed:
Jan 12, 2007
Appl. No.:
12/160875
Inventors:
Janine Shulok - Newton MA, US
Feng Cong - Quincy MA, US
Mark Fishman - Newton Center MA, US
Seth Ettenberg - Melrose MA, US
Michael Bardroff - Munchen, DE
Mariel Donzeau - Strasbourg, FR
Stefanie Urlinger - Nurnberg, DE
Feng Cong - Quincy MA, US
Mark Fishman - Newton Center MA, US
Seth Ettenberg - Melrose MA, US
Michael Bardroff - Munchen, DE
Mariel Donzeau - Strasbourg, FR
Stefanie Urlinger - Nurnberg, DE
International Classification:
C07K 16/18, A01K 67/027, A61P 35/00, A61P 17/14, A61P 3/04, A61P 21/00, A61P 25/28, A61P 29/00, A61K 39/395, A61P 3/10
US Classification:
800 13, 5303879, 5303891, 536 2353, 5303882, 5303873, 4241721, 4241351
Abstract:
Antibodies and fragments that bind to the protein target Dickkopf (DKK1) are provided, as are methods of use and kits, for treating a target cell, in particular, a cell associated with an osteolytic condition.
Methods For Diagnosing And Treating Diseases And Conditions Associated With Protein Kinase Cλ
US Patent:
7771931, Aug 10, 2010
Filed:
Sep 6, 2002
Appl. No.:
10/488292
Inventors:
Randall Peterson - Belmont MA, US
Mark C. Fishman - Newton Center MA, US
Mark C. Fishman - Newton Center MA, US
Assignee:
The General Hospital Corporation - Boston MA
International Classification:
C12Q 1/00, C12Q 1/68, C12P 21/06, C12P 19/34, A61K 38/00, C07H 21/00, C07H 21/04
US Classification:
435 6, 435 4, 435 691, 435 912, 536 231, 536 232, 536 253, 514 12
Abstract:
The invention provides methods of diagnosing diseases and conditions associated with PKCλ, methods for identifying compounds that can be used to treat or to prevent such diseases and conditions, and methods of using these compounds to treat or to prevent such diseases and conditions. Also provided in the invention are animal model systems that can be used in screening methods.
Methods For Diagnosing And Treating Heart Disease
US Patent:
2004026, Dec 30, 2004
Filed:
Sep 5, 2003
Appl. No.:
10/656873
Inventors:
Mark Fishman - Newton Center MA, US
Xiaolei Xu - Boston MA, US
Xiaolei Xu - Boston MA, US
International Classification:
C12Q001/68
US Classification:
435/006000
Abstract:
The invention provides methods of diagnosing heart disease, such as heart failure, screening methods for identifying compounds that can be used to treat or to prevent heart disease, and methods of using these compounds to treat or to prevent heart disease. The invention also provides animal model systems for carrying out the screening methods.
Methods For Diagnosing And Treating Heart Disease
US Patent:
2009007, Mar 19, 2009
Filed:
May 6, 2008
Appl. No.:
12/115986
Inventors:
Mark C. Fishman - Newton MA, US
John Mably - Medford MA, US
John Mably - Medford MA, US
Assignee:
The General Hospital Corporation - Boston MA
International Classification:
C12Q 1/68, C07K 14/435, C07H 21/00, C12N 15/63, C12N 5/06, A01K 67/027, C07K 16/00
US Classification:
800 20, 435 6, 530350, 536 235, 4353201, 435325, 5303879
Abstract:
The invention provides methods of diagnosing heart disease, such as heart failure, methods for identifying compounds that can be used to treat or to prevent heart disease, and methods of using these compounds to treat or to prevent heart disease. Also provided in the invention are animal model systems that can be used in screening methods.
Methods And Compositions For Treating Vascular Disease
US Patent:
2010004, Feb 25, 2010
Filed:
Jul 17, 2007
Appl. No.:
12/373917
Inventors:
Mark C. Fishman - Newton Center MA, US
Assignee:
The General Hospital Corporation - Boston MA
International Classification:
A61K 39/395, A61K 38/45, C12N 9/10, C12N 5/10, C12N 15/63, A61K 38/00, A61K 31/7088, C07H 21/04
US Classification:
4241391, 424 945, 435193, 435325, 4353201, 514 2, 514 44 R, 514 44 A, 536 232
Abstract:
This invention relates to compositions and methods for use in treating or preventing vascular disease, as well as diseases and conditions associated with hematopoiesis and cellular proliferation.