Inventors:
George D. Demetri - Brookline MA, US
Stephen T. Sonis - Wayland MA, US
Camille L. Bedrosian - Belmont MA, US
International Classification:
A61K 39/395, A61P 35/00, A61P 35/02
US Classification:
4241341, 4241331, 4241421
Abstract:
Disclosed are methods for treating various cancers. Methods encompass the administration of a first drug such as AP23573, temsirolimus or everolimus in combination with a second drug selected from Remicade, Humira, Enbrel, Raptiva, Abatacept, Actermra, Cimzia or anakinra.The methods are aimed at providing a desirable therapeutic window while maintaining prior, if not higher, dose levels of the first drug.