LYNELL W KLASSEN, MD
Osteopathic Medicine at Nebraska Medical Ctr, Omaha, NE
License number
Nebraska 16163
Category
Osteopathic Medicine
Type
Rheumatology
Address
Address
988102 Nebraska Medical Ctr, Omaha, NE 68198
Phone
(402) 559-4015
(402) 559-6788 (Fax)
(402) 559-6788 (Fax)
Personal information
See more information about LYNELL W KLASSEN at radaris.comName
Address
Phone
10294 Washington Dr, Omaha, NE 68127
Omaha, NE
10294 Washington St, Omaha, NE 68127
600 42Nd St, Omaha, NE 68198
983025 Nebraska Medical Ctr, Omaha, NE 68198
Organization information
See more information about LYNELL W KLASSEN at bizstanding.comUnmc Physicians - Lynell W Klassen MD
989500 Nebraska Medical Ctr, Omaha, NE 68198
Categories:
Dentists, Internal Medicine Physicians & Surgeons, Physicians & Surgeons, ...
Site:
Phone:
(402) 559-4015 (Phone)
Professional information
Lynell Warren Klassen, Omaha NE
Specialties:
Internal Medicine, Rheumatology
Work:
University of Nebraska
983332 Nebraska Medical Ctr, Omaha, NE 68198 Omaha - Va Nebraska-Western Iowa Health Care System
4101 Woolworth Ave, Omaha, NE 68105
983332 Nebraska Medical Ctr, Omaha, NE 68198 Omaha - Va Nebraska-Western Iowa Health Care System
4101 Woolworth Ave, Omaha, NE 68105
Education:
University of Kansas(1973)
Acetaldehyde And Malondialdehyde Protein Adducts As Markers For Alcohol Liver Disease
US Patent:
6814951, Nov 9, 2004
Filed:
May 25, 1999
Appl. No.:
09/318080
Inventors:
Geoffrey M. Thiele - Omaha NE
Thomas L. McDonald - Omaha NE
Dean J. Tuma - Omaha NE
Lynell W. Klassen - Omaha NE
Michael F. Sorrell - Omaha NE
Thomas L. McDonald - Omaha NE
Dean J. Tuma - Omaha NE
Lynell W. Klassen - Omaha NE
Michael F. Sorrell - Omaha NE
Assignee:
The Board of Regents of the University of Nebraska - Lincoln NE
International Classification:
A61K 4900
US Classification:
424 91, 424 96, 436506, 546315
Abstract:
A novel protein adduct is disclosed which is associated with the presence of alcohol liver disease. The adduct is a hybrid product of malondialdehyde and acetaldehyde which act synergistically to bind hepatic proteins. The adduct is highly immunogenic and fluorescent. Methods of detection are also disclosed including monoclonal and polyclonal antibodies.
Acetaldehyde And Malondialdehyde Protein Adducts
US Patent:
5939535, Aug 17, 1999
Filed:
Apr 8, 1997
Appl. No.:
8/817018
Inventors:
Geoffrey M. Thiele - Omaha NE
Thomas L. McDonald - Omaha NE
Dean J. Tuma - Omaha NE
Lynell W. Klassen - Omaha NE
Michael F. Sorrell - Omaha NE
Thomas L. McDonald - Omaha NE
Dean J. Tuma - Omaha NE
Lynell W. Klassen - Omaha NE
Michael F. Sorrell - Omaha NE
Assignee:
The Board of Regents of the University of Nebraska - Lincoln NE
International Classification:
C07K 100, C07D21170, C07C22100
US Classification:
530402
Abstract:
A novel protein adduct is disclosed which is associated with the presence of alcohol liver disease. The adduct is a hybrid product of malondialdehyde and acetaldehyde which act synergistically to bind hepatic proteins. The adduct is highly immunogenic and fluorescent. Methods of detection are also disclosed including monoclonal and polyclonal antibodies.
High Fluorescence Specific Immune Enhancing Factor And Methods Of Use For Same
US Patent:
6120777, Sep 19, 2000
Filed:
May 27, 1997
Appl. No.:
8/849024
Inventors:
Geoffrey M. Thiele - Omaha NE
Thomas L. McDonald - Omaha NE
Dean J. Tuma - Omaha NE
Lynell W. Klassen - Omaha NE
Michael F. Sorrell - Omaha NE
Thomas L. McDonald - Omaha NE
Dean J. Tuma - Omaha NE
Lynell W. Klassen - Omaha NE
Michael F. Sorrell - Omaha NE
Assignee:
The Board of Regents of the University of Nebraska - Lincoln NE
International Classification:
A61K 3900, A61K 4500, C07D21300
US Classification:
4242781
Abstract:
The present invention relates to a malondialdehyde-acetaldehyde adduct which acts as a specific immune-enhancing factor. In addition to its highly specific and immunogenic properties, the factor is highly fluorescent. It has an excitation frequency of about 398 nanometers and an absorbance of about 460 nanometers. The factor is also highly reactive and is also adducted to antigens including complex proteins, lipids, carbohydrates or DNA.