Inventors:
John P. Carulli - Southboro MA
Randall D. Little - Newtonville MA
Robert R. Recker - Omaha NE
Mark L. Johnson - Omaha NE
Assignee:
Genome Therapeutics Corporation - Waltham MA
Creighton University School of Medicine - Omaha NE
International Classification:
C12P 2100
US Classification:
435 701, 435325, 4352523, 4353201, 435 711, 435 712
Abstract:
The present invention relates to methods and materials used to isolate and detect a high bone mass gene and a corresponding wild-type gene, and mutants thereof. The present invention also relates to the high bone mass gene, the corresponding wild-type gene, and mutants thereof The genes identified in the present invention are implicated in bone development. The invention also provides nucleic acids, including coding sequences, oligonucleotide primers and probes, proteins, cloning vectors, expression vectors, transformed hosts, methods of developing pharmaceutical compositions, methods of identifying molecules involved in bone development, and methods of diagnosing and treating diseases involved in bone development. In preferred embodiments, the present invention is directed to methods for treating, diagnosing and preventing osteoporosis.