Inventors:
Lisa A. Beck - Rochester NY, US
Anna De Benedetto - Rochester NY, US
Assignee:
UNIVERSITY OF ROCHESTER - Rochester NY
International Classification:
A61K 38/20, A61K 39/12, A61K 39/35, A61K 31/713, A61K 9/70, A61K 35/36, A61K 38/16, A61K 31/426, A61K 31/7105, A61P 31/00, A61P 37/04, A61P 31/12, A61P 37/08, A61P 17/00, A61K 39/00
US Classification:
424443, 424 852, 4241841, 4242041, 4242751, 514 44 A, 424574, 514 186, 514369, 514 23
Abstract:
Methods are provided for modulating expression of claudin-1 and/or claudin-23, for purposes of regulating formation of tight junctions in keratinocytes or other types of cells such as antigen presenting cells (e.g., dendritic cells and Langertians cells), by either increasing or decreasing expression of claudin-1 and/or claudin-23. Also provided are transdermal formulations that decrease expression of claudin-1 and/or claudin-23, thereby diminishing tight junction formation in cells expressing claudin-1 and/or claudin-23, as well as a transdermal patch for delivering the same.