DR. LEO THEODORE FURCHT, M.D.
Medical Practice at Delaware St, Minneapolis, MN

5294551, Mar 15, 1994

Sep 9, 1992

7/942597

Leo T. Furcht - Minneapolis MN
James B. McCarthy - Minneapolis MN

Regents of the University of Minnesota - Minneapolis MN

C12N 500, C12N 1108, C12N 1106, C07K 700

435240243

A composition which can bind heparin and promote cellular adhesion and neurite outgrowth is provided which consists essentially of a polypeptide of the formula: tyr-glu-lys-pro-gly-ser-pro-pro-arg-glu-val-val-pro-arg-pro-arg-pro-gly-val lys-asn-asn-gln-lys-ser-glu-pro-leu-ile-gly-arg-lys-lys-thr-asp-glu-leu, lys-asn-asn-gln-lys-ser-glu-pro-leu-ile-gly-arg-lys-lys-thr, leu-ile-gly-arg-lys-lys-thr, tyr-arg-val-arg-val-thr-pro-lys-glu-lys-thr-gly-pro-met-lys-glu, ser-pro-pro-arg-arg-ala-arg-val-thr, trp-gln-pro-pro-arg-ala-arg-ile, or mixtures thereof. Medical devices such as prosthetic implants, percutaneous devices and cell culture substrates coated with the polypeptide composition are also provided. Cell culture substrates provided can be made of a synthetic resin and in the form of a bead, microporous fiber or well of a microtiter plate.

5731409, Mar 24, 1998

Oct 28, 1994

8/330599

Gregg B. Fields - Brooklyn Park MN
Leo T. Furcht - Minneapolis MN
James B. McCarthy - Minneapolis MN

Regents of the University of Minnesota - Minneapolis MN

A61K 3800, C07K 500, C07K 700, C07K 300

530324

Polypeptides are provided that have a sequence of at least about four amino acids corresponding substantially to an amino acid sequence within the triple-helical domain of Type I collagen. The polypeptides promote cell adhesion and/or cell migration. Cell culture substrates coated with the polypeptides are also provided. Prosthetic devices and methods for identifying and distinguishing cells of different types are also provided.

5081031, Jan 14, 1992

Dec 14, 1989

7/450629

Leo T. Furcht - Minneapolis MN

Regents of the University of Minnesota - Minneapolis MN

C12M 100, C07K 708, A61F 202, A61F 206

43524023

A polypeptide having the following formula is provided: leu-ala-gly-ser-cys-leu-ala-arg-phe-ser-thr-met which can bind heparin and promote cellular adhesion. Medical devices such as prosthetic implants, percutaneous devices and cell culture substrates coated with a composition including the polypeptide are also provided.

5276136, Jan 4, 1994

Jun 8, 1992

7/895252

Leo T. Furcht - Minneapolis MN

Regents of the University of Minnesota - Minneapolis MN

C07K 708, C07K 710, A61K 3702

530326

Polypeptides derived from domain VI of the amino terminal globule of the A chain of laminin and having sequences of at least about 5 amino acids, and which exhibit cell adhesion and cell spreading capacity are described. Medical devices such as prosthetic implants, percutaneous devices and cell culture substrates coated w GOVERNMENT SUPPORT This invention was made with government support under contract No. CA-29995 by the U. S. National Institutes of Health. The government has certain rights in the invention.

5242826, Sep 7, 1993

May 24, 1991

7/705086

Effie C. Tsilibary - Minneapolis MN
Leo T. Furcht - Minneapolis MN

Regents of the University of Minnesota - Minneapolis MN

C12M 300, C12N 1102, C12N 500, A61K 3702

435287

A polypeptide which can bind heparin and promote cellular adhesion is provided, which consists essentially of a polypeptide having a formula selected from the group consisting of: met-phe-lys-lys-pro-thr-pro-ser-thr-leu-lys-ala-gly-glu-leu-arg, thr-ala-gly-ser-cys-leu-arg-lys-phe-ser-thr met, asn-pro-leu-cys-pro-pro-gly-thr-lys-ile-leu, and mixtures thereof. Medical devices such as prosthetic implants, percutaneous devices, bandages and cell culture substrates coated with the polypeptide composition are also provided.

5840691, Nov 24, 1998

Jun 7, 1995

8/480133

Leo T. Furcht - Minneapolis MN
James B. McCarthy - Minneapolis MN
Sharon M. Wahl - Gaithersburg MD
Janice B. Allen - Wendell NC
Kevin L. Billups - Savage MN
Jeffrey E. Everett - Arden Hills MN

A61K 3804, A61K 3808, A61K 3810, A61K 3816

814 12

Methods for treating ischemia using polypeptides with fibronectin related activity are provided. The methods involve administering an effective amount of one or more polypeptides which include an amino acid sequence corresponding substantially to isolated an amino acid sequence from the 33 kD carboxy terminal heparin-binding region located on the A chain of fibronectin or an RGD-containing amino acid sequence within the 11. 5 kD RGDS-mediated cell adhesion region located on all isoforms of fibronectin.

7015037, Mar 21, 2006

Aug 21, 2002

10/048757

Leo T. Furcht - Minneapolis MN, US
Catherine M. Verfaillie - St. Paul MN, US
Morayma Reyes - Minneapolis MN, US

Regents of the University of Minnesota - Minneapolis MN
MCL/LLC - Minneapolis MN

C12N 5/00

435372, 435325, 435366

The invention provides isolated stem cells of non-embryonic origin that can be maintained in culture in the undifferentiated state or differentiated to form cells of multiple tissue types. Also provided are methods of isolation and culture, as well as therapeutic uses for the isolated cells.

2006017, Aug 10, 2006

Jan 12, 2006

11/332592

Leo Furcht - Golden Valley MN, US

A61F 2/24, A61F 2/28, A61F 2/82

623001460, 623002420, 623023510

Medical apparatus for medical treatment of a patient are disclosed. The medical apparatus include a diamond coating on at least a portion of the surface of the body of the medical apparatus.

7659118, Feb 9, 2010

Sep 29, 2005

11/238234

Leo T. Furcht - Minneapolis MN, US
Catherine M. Verfaillie - St. Paul MN, US
Morayma Reyes - Minneapolis MN, US

ABT Holding Company - Cleveland OH
Regents of the University of Minnesote - St. Paul MN

C12N 5/00

435366, 435325

The invention provides isolated stem cells of non-embryonic origin that can be maintained in culture in the undifferentiated state or differentiated to form cells of multiple tissue types. Also provided are methods of isolation and culture, as well as therapeutic uses for the isolated cells.