DR. LAWRENCE C. HOROWITZ, M.D.
Osteopathic Medicine at Selby Ln, Menlo Park, CA
License number
California G28453
Category
Osteopathic Medicine
Type
General Practice
Address
Address
356 Selby Ln, Menlo Park, CA 94027
Phone
(650) 216-8100
(650) 365-4848 (Fax)
(650) 365-4848 (Fax)
Personal information
See more information about LAWRENCE C. HOROWITZ at radaris.comName
Address
Phone
362 Selby Ln, Atherton, CA 94027
1657 Finecroft Dr, Claremont, CA 91711
18855 Victory Blvd, Reseda, CA 91335
19543 Oxnard St, Tarzana, CA 91356
362 Selby Ln, Atherton, CA 94027
Professional information
Design And Construction Of Diverse Synthetic Peptide And Polypeptide Libraries
US Patent:
2012012, May 24, 2012
Filed:
Dec 14, 2011
Appl. No.:
13/374203
Inventors:
Lawrence Horowitz - Atherton CA, US
Ramesh Bhatt - Belmont CA, US
Aaron L. Kurtzman - San Carlos CA, US
Ramesh Bhatt - Belmont CA, US
Aaron L. Kurtzman - San Carlos CA, US
International Classification:
C40B 50/06
US Classification:
506 26
Abstract:
The present invention concerns the design and construction of diverse peptide and polypeptide libraries. In particular, the invention concerns methods of analytical database design for creating datasets using multiple relevant parameters as filters, and methods for generating sequence diversity by directed multisyntheses oligonucleotide synthesis. The present methods enable the reduction of large complex annotated databases to simpler datasets of related sequences, based upon relevant single or multiple key parameters that can be individually directly defined. The methods further enable the creation of diverse libraries based on this approach, using multisynthetic collections of discrete and degenerate oligonucleotides to capture the diverse collection of sequences, or portions thereof.
Constructs And Libraries Comprising Antibody Surrogate Light Chain Sequences
US Patent:
8114967, Feb 14, 2012
Filed:
Mar 26, 2008
Appl. No.:
12/056151
Inventors:
Ramesh Bhatt - Belmont CA, US
Lawrence Horowitz - Atherton CA, US
Li Xu - Cupertino CA, US
Lawrence Horowitz - Atherton CA, US
Li Xu - Cupertino CA, US
Assignee:
Sea Lane Biotechnologies LLC - Atherton CA
International Classification:
C07K 1/00, C07K 14/00, C07K 16/00, C12P 21/08, G01N 33/00, C40B 40/02
US Classification:
5303873, 530350, 5303871, 436512, 436 86
Abstract:
The invention concerns constructs and libraries comprising antibody surrogate light chain sequences. In particular, the invention concerns constructs comprising VpreB sequences, optionally partnered with another polypeptide, such as, for example, antibody heavy chain variable domain sequences, and libraries containing the same.
Combinatorial Libraries Of Conformationally Constrained Polypeptide Sequences
US Patent:
2013028, Oct 31, 2013
Filed:
Nov 11, 2011
Appl. No.:
13/294772
Inventors:
Lawrence Horowitz - Atherton CA, US
Ramesh R. Bhatt - Belmont CA, US
Aaron L. Kurtzman - San Carlos CA, US
Ramesh R. Bhatt - Belmont CA, US
Aaron L. Kurtzman - San Carlos CA, US
International Classification:
G01N 33/543
US Classification:
506 2, 506 9, 506 14
Abstract:
The present invention concerns combinatorial libraries of conformationally constrained polypeptide sequences and their uses. In particular, the present invention concerns combinatorial libraries of conformational epitopes and their uses.
Donor Specific Antibody Libraries
US Patent:
2012026, Oct 18, 2012
Filed:
Mar 16, 2012
Appl. No.:
13/422313
Inventors:
Lawrence Horowitz - Atherton CA, US
Ramesh Bhatt - Belmont CA, US
Arun K. Kashyap - Newark CA, US
Ramesh Bhatt - Belmont CA, US
Arun K. Kashyap - Newark CA, US
International Classification:
C40B 40/02
US Classification:
506 14
Abstract:
The present invention concerns donor-specific antibody libraries derived from a patient donor who has suffered from, or is suffering from one or more diseases discussed herein. The present invention also concerns the method of making and using the donor-specific antibodies. The present invention further concerns the neutralizing antibodies obtained from the donor-specific antibody libraries and the methods of using these antibodies for the prevention/treatment of human disease.
Constructs And Libraries Comprising Antibody Surrogate Light Chain Sequences
US Patent:
2012020, Aug 9, 2012
Filed:
Feb 10, 2012
Appl. No.:
13/371347
Inventors:
Ramesh Bhatt - Belmont CA, US
Lawrence Horowitz - Atherton CA, US
Li Xu - Cupertino CA, US
Lawrence Horowitz - Atherton CA, US
Li Xu - Cupertino CA, US
International Classification:
C40B 40/10, C07K 19/00
US Classification:
506 18, 5303873
Abstract:
The invention concerns constructs and libraries comprising antibody surrogate light chain sequences. In particular, the invention concerns constructs comprising VpreB sequences, optionally partnered with another polypeptide, such as, for example, antibody heavy chain variable domain sequences, and libraries containing the same.
Constructs And Libraries Comprising Antibody Surrogate Kappa Light Chain Sequences
US Patent:
2010006, Mar 11, 2010
Filed:
Jul 10, 2009
Appl. No.:
12/501281
Inventors:
Ramesh R. Bhatt - Belmont CA, US
Lawrence Horowitz - Atherton CA, US
Lawrence Horowitz - Atherton CA, US
International Classification:
C40B 40/02, C12P 21/08, C40B 40/10, C40B 40/06
US Classification:
506 14, 5303873, 506 18, 506 16
Abstract:
The present invention concerns constructs and libraries comprising antibody surrogate κ light chain sequences. In particular, the invention concerns constructs comprising antibody surrogate κ light chain sequences, optionally partnered with another polypeptide, such as, for example, antibody heavy and/or light chain domain sequences, and libraries containing the same.
Neutralizing Molecules To Viral Antigens
US Patent:
2012009, Apr 19, 2012
Filed:
Jul 18, 2011
Appl. No.:
13/185386
Inventors:
Lawrence HOROWITZ - Atherton CA, US
Ramesh Bhatt - Belmont CA, US
Arun Kashyap - Newark CA, US
Ramesh Bhatt - Belmont CA, US
Arun Kashyap - Newark CA, US
International Classification:
A61K 39/145, A61P 31/16, A61P 37/04, A61K 39/395
US Classification:
4241591, 4242101
Abstract:
The present invention concerns methods and means for identifying, producing, and engineering neutralizing molecules against influenza A viruses, and to the neutralizing molecules produced. In particular, the invention concerns neutralizing molecules against various influenza A virus subtypes, including neutralizing antibodies against H5 and/or H3 and/or H1, such as, for example all of H1, H3, and H5 subtypes, and methods and means for making such molecules.
Neutralizing Antibodies To Influenza Viruses
US Patent:
2012010, May 3, 2012
Filed:
Aug 10, 2011
Appl. No.:
13/207083
Inventors:
Lawrence HOROWITZ - Atherton CA, US
Ramesh Bhatt - Belmont CA, US
Arun K. Kashyap - Newark CA, US
Ramesh Bhatt - Belmont CA, US
Arun K. Kashyap - Newark CA, US
International Classification:
A61K 39/42, A61P 31/16
US Classification:
4241591
Abstract:
The present invention concerns methods and means for identifying, producing, and engineering neutralizing antibodies against influenza A viruses, and to the neutralizing antibodies produced. In particular, the invention concerns neutralizing antibodies against various influenza A virus subtypes, including neutralizing antibodies against two or more of H1, H2, H3, H5, H7 and H9, such as, for example all of H1, H2, H3, and H5 subtypes, and methods and means for making such antibodies. More specifically, the invention concerns antibodies capable of neutralizing more than one, preferably all, isolates of an influenza A virus subtype.
Expression Of Surrogate Light Chains
US Patent:
2010033, Dec 30, 2010
Filed:
Jun 25, 2010
Appl. No.:
12/824058
Inventors:
Lawrence Horowitz - Atherton CA, US
Ramesh R. Bhatt - Belmont CA, US
Ramesh R. Bhatt - Belmont CA, US
International Classification:
C12N 15/79, C12N 15/13, C12N 15/63, C12N 5/07
US Classification:
435455, 536 2353, 536 234, 536 232, 536 2351, 4353201, 435325
Abstract:
The present invention concerns surrogate light chain (SURROBODY™) constructs comprising surrogate light chain sequences with heterologous signal sequences.
Spore Associated Display
US Patent:
2009009, Apr 16, 2009
Filed:
Aug 13, 2008
Appl. No.:
12/228655
Inventors:
Ramesh Bhatt - Belmont CA, US
Lawrence Horowitz - Atherton CA, US
Angeles Estelles - Belmont CA, US
Lawrence Horowitz - Atherton CA, US
Angeles Estelles - Belmont CA, US
International Classification:
A61K 39/07, C07K 2/00, C07K 14/00, C07K 16/12, C12N 9/96, C07H 21/04, C12N 1/21, C40B 40/10, C40B 40/06, C12N 15/74
US Classification:
4242461, 530300, 530350, 5303873, 435188, 536 234, 536 2371, 4352523, 506 18, 506 16, 435471
Abstract:
The present invention concerns spore display methods. More specifically, the invention concerns display of heterologous molecules, such as peptides and polypeptides, on spores of bacilli, such as, for example, (Bt) or (BC), using externally exposed spore coat proteins or fragments or variants thereof.