Inventors:
Jianhua Zhang - Birmingham AL, US
Guy Caldwell - Northport AL, US
Kevin Roth - Birmingham AL, US
David Standaert - Birmingham AL, US
Kim Cladwell - Northport AL, US
Shusei Hamamichi - Tuscaloosa AL, US
Assignee:
THE UAB RESEARCH FOUNDATION - Birmingham AL
THE UNIVERSITY OF ALABAMA - Tuscaloosa AL
International Classification:
A61K 39/395, C12Q 1/37, A61K 38/02, A61P 25/28, A61P 25/16, A61K 31/7088, C12Q 1/68, A61K 38/48
US Classification:
4241301, 435 23, 514 178, 514 44 R, 435 6, 424 9466, 514 177
Abstract:
Provided herein are methods and compositions for promoting neuroprotection in a subject and for treating a neural disorder associated with protein aggregation comprising administering to the subject an agent that increases expression or activity of cathepsin-D. Also provided are methods of screening for agents that increase expression or activity of cathepsin-D and methods of screening for neuroprotective agents.