Inventors:
Kathleen Pratt - Seattle WA, US
Ruth Ettinger - Seattle WA, US
Eddie Arthur James - Monroe WA, US
International Classification:
A61K 38/37, C07K 14/755
US Classification:
514 141, 530383, 536 235, 4353201, 435 696, 43525233, 43525421, 43525411, 435348, 435419, 435366, 435325
Abstract:
Provided herein are methods and compositions for preventing or reducing an initial immune response to factor VIII in patients suffering from hemophilia A, and for reducing the intensity of the immune response in patients having pre-formed inhibitor antibodies against factor VIII.