KARL DEISSEROTH, MD
Psychiatric at Pasteur Dr, Palo Alto, CA
License number
California A75949
Category
Psychiatric
Type
Psychiatry
Address
Address
300 Pasteur Dr, Palo Alto, CA 94305
Phone
(650) 498-5710
Organization information
See more information about KARL DEISSEROTH at bizstanding.comKarl Deisseroth MD
401 Quarry Rd, Palo Alto, CA 94304
Industry:
Psychiatrist
Site:
Phone:
(650) 498-9111 (Phone)
Karl Alexander Deisseroth
Professional information
System For Optical Stimulation Of Target Cells
US Patent:
2010019, Jul 29, 2010
Filed:
Jan 9, 2008
Appl. No.:
12/522528
Inventors:
Feng Zhang - Stanford CA, US
Karl Deisseroth - Palo Alto CA, US
David J. Mishelevich - Playa Del Rey CA, US
M. Bret Schneider - Portola Valley CA, US
Karl Deisseroth - Palo Alto CA, US
David J. Mishelevich - Playa Del Rey CA, US
M. Bret Schneider - Portola Valley CA, US
International Classification:
C12N 13/00, C12N 5/079
US Classification:
4351731, 435375
Abstract:
Stimulation of target cells using light, e.g., in vivo, is implemented using a variety of methods and devices. In one example, embodiments involve methods for stimulating target cells using a photosensitive protein that allows the target cells to be stimulated in response to light. In another specific example embodiment, target cells are stimulated using an implantable arrangement. The arrangement includes an electrical light-generation means for generating light and a biological portion. The biological portion has a photosensitive bio-molecular arrangement that responds to the generated light by stimulating target cells in vivo. Other aspects and embodiments are directed to systems and methods for screening chemicals based screening chemicals to identify their effects on cell membrane ion channels and pumps, and to systems and methods for controlling an action potential of neuron (e.g., in vivo and in vitro environments).
Coupling Of Excitation And Neurogenesis In Neural Stem/Progenitor Cells
US Patent:
2005026, Dec 1, 2005
Filed:
May 19, 2005
Appl. No.:
11/134720
Inventors:
Karl Deisseroth - Palo Alto CA, US
Robert Malenka - Palo Alto CA, US
Robert Malenka - Palo Alto CA, US
International Classification:
A61K038/17
US Classification:
514002000
Abstract:
Coupling of excitation to neurogenesis in proliferating post-natal NPCs is demonstrated in vitro and in vivo. Neurogenesis is potently enhanced by excitatory stimuli, and involves Ca1.2/1.3 channels and NMDA receptors. These Ca influx pathways are located on the proliferating NPCs, allowing them to directly sense and process excitatory stimuli. Excitation increases the fraction of NPC progeny that are neurons, and increases total neuron number. Signaling in this pathway leads to rapid induction of a proneural gene expression pattern involving the bHLH genes HES1, Id2, and NeuroD, and the resulting cells become fully functional neurons defined by neuronal morphology, expression of neuronal structural proteins, expression of neuronal TTX-sensitive voltage gated Na channels, and synaptic incorporation into active neural circuits.
System, Method And Applications Involving Identification Of Biological Circuits Such As Neurological Characteristics
US Patent:
8401609, Mar 19, 2013
Filed:
Feb 14, 2008
Appl. No.:
12/031651
Inventors:
Karl Deisseroth - Palo Alto CA, US
Raag D. Airan - Menlo Park CA, US
Leslie A. Meltzer - Palo Alto CA, US
Raag D. Airan - Menlo Park CA, US
Leslie A. Meltzer - Palo Alto CA, US
Assignee:
The Board of Trustees of the Leland Stanford Junior University - Palo Alto CA
International Classification:
A61B 5/05
US Classification:
600407, 607 1
Abstract:
Various aspects are directed to systems and methods for assessing neural activity of a neural region having multiple subfields. In certain embodiments, a method includes evoking a cellular electrical response in at least one subfield due to neural activity in the neural region, capturing image data of the electrical response at a level sufficiently detailed in space and time to differentiate between polarization-based events of two respective portions of the subfield, and then assessing neural activity by correlating space and time information, from the captured data, for the two respective portions of the sub-field. Other more specific aspects of the invention involve different preparation and neural stimulation approaches which can vary depending on the application.
Optically-Based Stimulation Of Target Cells And Modifications Thereto
US Patent:
2011031, Dec 22, 2011
Filed:
Nov 13, 2009
Appl. No.:
13/128979
Inventors:
Karl Deisseroth - Palo Alto CA, US
Ofer Yizhar - Palo Alto CA, US
Lisa Gunaydin - Stanford CA, US
Peter Hegemann - Falkensee, DE
Andre Berndt - Berlin, DE
Ofer Yizhar - Palo Alto CA, US
Lisa Gunaydin - Stanford CA, US
Peter Hegemann - Falkensee, DE
Andre Berndt - Berlin, DE
International Classification:
A61K 48/00, C07H 21/00, C12Q 1/02, C07K 1/107, C12N 13/00, A61P 25/00, C07K 14/405, C12N 15/63
US Classification:
424 932, 530370, 536 236, 4353201, 4351731, 514 44 R, 435 29
Abstract:
Stimulation of target cells using light, e.g., in vivo or in vitro, is implemented using a variety of methods and devices. One example involves a vector for delivering a light-activated molecule comprising a nucleic acid sequence that codes for light-activated molecule. The light-activated molecule includes a modification to a location near the all-trans retinal Schiff base, e.g., to extends the duration time of the open state. Other aspects and embodiments are directed to systems, methods, kits, compositions of matter and molecules for ion channels or pumps or for controlling currents in a cell (e.g., in in vivo and in vitro environments).
Implantable Optical Stimulators
US Patent:
2009011, May 7, 2009
Filed:
Oct 31, 2008
Appl. No.:
12/263044
Inventors:
Karl Deisseroth - Palo Alto CA, US
M. Bret Schneider - Portola Valley CA, US
M. Bret Schneider - Portola Valley CA, US
International Classification:
A61N 5/06
US Classification:
607 92
Abstract:
Various systems and methods are implemented for in vivo use in a living animal. One such method involves stimulating target cells having light-responsive proteins and includes providing an elongated light-delivery structure in a narrow passageway in the animal, the elongated light-delivery structure having separately-activatable light sources located along the length of the elongated light-delivery structure. The method also includes activating less than all the light sources to deliver light to light-responsive proteins adjacent to the activated light sources along the length of the elongated light-delivery structure, thereby stimulating target cells in vivo.
Optogenetic Magnetic Resonance Imaging
US Patent:
2012016, Jun 28, 2012
Filed:
Nov 18, 2011
Appl. No.:
13/299727
Inventors:
Jin Hyung Lee - Los Angeles CA, US
Karl Deisseroth - Palo Alto CA, US
Karl Deisseroth - Palo Alto CA, US
International Classification:
A61N 5/06
US Classification:
607 90
Abstract:
Disclosed herein are systems and methods involving the use of magnetic resonance imaging and optogenetic neural stimulation. Aspects of the disclosure include modifying a target neural cell population in a first region of a brain to express light-responsive molecules. Using a light pulse, the light-responsive molecules in the target neural cell population are stimulated. Multiple regions of the brain are scanned via magnetic resonance imaging. The scans allow for observation of a neural reaction in response to the stimulation in at least one of the multiple regions of the brain.
Systems, Methods And Compositions For Optical Stimulation Of Target Cells
US Patent:
8603790, Dec 10, 2013
Filed:
Apr 8, 2009
Appl. No.:
12/988567
Inventors:
Karl Deisseroth - Palo Alto CA, US
Feng Zhang - Cambridge MA, US
Viviana Gradinaru - Menlo Park CA, US
Feng Zhang - Cambridge MA, US
Viviana Gradinaru - Menlo Park CA, US
Assignee:
The Board of Trustees of the Leland Stanford Junior University - Palo Alto CA
International Classification:
C12N 13/00, C12N 1/20, C12N 15/00, C12N 5/00, C12N 5/02, C12Q 1/02, A61F 5/00
US Classification:
4351731, 435 29, 4352523, 4353201, 435325, 435375, 435471, 604 20
Abstract:
Methods, systems and devices are implemented in connection with light-responsive ion channel molecules. One such method is implemented using a light-activated ion channel molecule that responds to a light stimulus. The method includes engineering the light-activated ion channel molecule in a cell; and activating the ion channel molecule, in response to light stimulus that is provided to the ion channel molecule and that has properties that do not activate a ChR2 ion channel, to allow ions to pass through the light-activated ion channel molecule.
Light-Activated Cation Channel And Uses Thereof
US Patent:
2010023, Sep 16, 2010
Filed:
Mar 1, 2010
Appl. No.:
12/715259
Inventors:
Edward S. Boyden - Palo Alto CA, US
Karl Deisseroth - Palo Alto CA, US
Karl Deisseroth - Palo Alto CA, US
International Classification:
A61K 38/28, A61P 25/00, A61K 38/16, A61P 25/24, A61P 25/16, A61P 25/02
US Classification:
514 3, 514 12
Abstract:
The present invention provides compositions and methods for light-activated cation channel proteins and their uses within cell membranes and subcellular regions. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-activated cation channels to specific cells or defined cell populations. In particular the invention provides millisecond-timescale temporal control of cation channels using moderate light intensities in cells, cell lines, transgenic animals, and humans. The invention provides for optically generating electrical spikes in nerve cells and other excitable cells useful for driving neuronal networks, drug screening, and therapy.
Control And Characterization Of Psychotic States
US Patent:
2014008, Mar 20, 2014
Filed:
Nov 4, 2011
Appl. No.:
13/882566
Inventors:
Karl Deisseroth - Stanford CA, US
Vikaas Sohal - San Francisco CA, US
Lisa Gunaydin - Stanford CA, US
Vikaas Sohal - San Francisco CA, US
Lisa Gunaydin - Stanford CA, US
Assignee:
The Board of Trustees of the Leland Stanford Junior University - Palo Alto CA
International Classification:
A01K 67/027, G01N 33/50, A61N 5/06, A61K 49/00
US Classification:
800 9, 435325, 424 92, 435 29, 4351734, 607 88
Abstract:
Provided herein are methods of inducing psychosis in animals using light-responsive opsins and methods of identifying or screening compounds that may be useful in treating psychosis.
Light-Sensitive Ion-Passing Molecules
US Patent:
2013001, Jan 17, 2013
Filed:
Mar 17, 2011
Appl. No.:
13/577565
Inventors:
Karl Deisseroth - Palo Alto CA, US
Feng Zhang - Cambridge MA, US
Viviana Gradinaru - Menlo Park CA, US
Feng Zhang - Cambridge MA, US
Viviana Gradinaru - Menlo Park CA, US
International Classification:
C12N 5/10, A01K 67/00, C12N 13/00
US Classification:
800 8, 435325, 4351731, 4351734
Abstract:
Disclosed are polynucleotides and methods for expressing light activated proteins in animal cells and altering an action potential of the cells by optical stimulation. The disclosure also provides animal cells and non-human animals comprising cells expressing the light-activated proteins.