Inventors:
John T. Strony - Lebanon NJ, US
Madhu Chintala - Colts Neck NJ, US
International Classification:
A61K 31/7076, A61K 31/519, A61K 31/517, A61P 9/10, A61P 9/00, A61K 31/443, A61K 31/444, A61P 7/02, A61K 31/4365, A61K 31/5377
US Classification:
514 47, 514301, 5142611, 51426624, 5142352
Abstract:
The treatment and prevention of thrombotic events are provided through co-administration of PAR-1 and the P2Y12 ADP receptor antagonists. Combined inhibition of the PAR-1 and the P2Y12 ADP platelet activation pathways had synergistic antithrombotic and antiplatelet effects, as demonstrated in co-administration of SCH 602539 and cangrelor.