Inventors:
Larry Yun Fang - Plainsboro NJ, US
David Harris - New Providence NJ, US
Gopal Krishna - North Brunswick NJ, US
Russell C. Prestipino - Hoboken NJ, US
Marc Steinman - Livingston NJ, US
Jiansheng Wan - Warren NJ, US
Hetty Anne Waskin - Skillman NJ, US
International Classification:
A61K 31/496, A61K 9/14, A61P 31/10
Abstract:
The present application provides novel compositions comprising posaconazole and a polymer wherein the composition has a glass transition temperature (Tg) of less than about 1100 C. The application also describes compositions comprising posaconazole and a polymer having a bulk density of greater than about 0.4 mg/mL. The application also describes compositions comprising posaconazole and a polymer which provide an exposure (AUCtf) of at least about 10,000 ng·hr/mL when administered to a patient in a fasted state. The application also describes a novel process for preparing these compositions. The preff erred polymer is HPMCAS. Preferably the composition is an extruded material.