DR. JOHN RUAN STEPHENS, M.D.
Osteopathic Medicine in Chapel Hill, NC

License number

North Carolina 200100474

Professional information

Dr. John R Stephens, Chapel Hill NC - MD (Doctor of Medicine)

Specialties:

Internal Medicine, Pediatrics

Address:

5034 Old Clinic, Chapel Hill 27599
(919) 966-3204 (Phone), (919) 966-3766 (Fax)

Certifications:

Internal Medicine, 2001, Pediatrics, 2001

Awards:

Healthgrades Honor Roll

Languages:

English

Education:

Medical School
University of North Carolina At Chapel Hill
Graduated: 1997
University Of North Carolina Hospitals

Hexahydroindenopyridine Compounds Having Antispermatogenic Activity

US Patent:

5952336, Sep 14, 1999

Filed:

Jan 31, 1997

Appl. No.:

8/792611

Inventors:

C. Edgar Cook - Staunton VA
Joseph M. Jump - Warwick RI
Pingsheng Zhang - Millbrae CA
John R. Stephens - Chapel Hill NC
Patricia A. Fail - Apex NC
Mansukh C. Wani - Durham NC

Assignee:

Research Triangle Institute - Research Triangle Park NC

International Classification:

A61K 3144, C07D22116

US Classification:

514290

Abstract:

Hexahydroindenopyridine compounds having the following formula and relative stereochemistry ##STR1## where R. sup. 1 is C. sub. 1-6 alkyl; R. sup. 2 is hydrogen or C. sub. 1-6 alkyl; R. sup. 3 is carboxyl or a group which is metabolized to a carboxyl group under mammalian physiological conditions; R. sup. 4 is halogen; mixtures of said compound and acid addition salts thereof exhibit potent antispermatogenic activity and are useful in a method of inhibiting spermatogenesis in mammals.