Inventors:
Mark R. Kelley - Zionsville IN
John Duquid - Brownsburg IN
John Eble - Indianapolis IN
Assignee:
Advanced Research & Technology Institute - Bloomington IN
International Classification:
A61K 39395, A61K 31711
Abstract:
Disclosed are methods and compositions for identifying, monitoring and treating premalignant and malignant conditions in a human subject. The present invention further discloses methods and compositions for determining cells undergoing apoptosis, and for increasing the efficacy of a cancer therapy. The methods involve the use of apurinic/apyrimidinic endonuclease (APE), independently, as a marker for (pre)malignant conditions and for apoptosis. Also described are polyclonal antibody preparations for use in methods for detecting APE and methods for modulating expression susceptibility of cells to apoptosis.