WILLIAM W. THOMPSON, M.D.
Anesthesiologist Assistant at Clearvista Pkwy, Indianapolis, IN

5635216, Jun 3, 1997

Dec 16, 1993

8/168941

William W. Thompson - Indianapolis IN

Eli Lilly and Company - Indianapolis IN

A61K 914

424501

A composition of polyester microparticles containing bioactive polypeptide agents and methods for preparing the composition and administering bioactive agents. The composition comprises biocompatible, biodegradable microparticles having a polyester matrix and from about 5% to about 25% by weight of a biologically active, water-soluble polypeptide dispersed throughout the matrix, the polypeptide selected from the group consisting of growth hormone releasing factor, synthetic analogs of growth hormone releasing factor, pharmacologically active fragment thereof and somatogenin. The method for preparing the composition includes dissolving polyester in an organic solvent; suspending a biologically active agent in the polyester solution; emulsifying the suspension into an aqueous medium in which the agent is insoluble and evaporating the solvent from the emulsion to produce microparticles. The method for administering a bioactive agent to an organism involves suspending the microparticles in a suitable liquid and injecting the organism.

6933318, Aug 23, 2005

Jul 26, 2000

10/048242

James Web Kassebaum - Indianapolis IN, US
Paul Thomas Pugh - Knightstown IN, US
William Webster Thompson - Indianapolis IN, US

Eli Lilly and Company - Indianapolis IN

A01N043/02, A61K031/335

514450

This invention provides topical ectoparasiticidal fomulations comprising an ectoparasiticide, preferably a pyrethroid or a spinosyn, a spreading agent at is a (C-C) branched alkyl (C-C) alkanoate, preferably isopropyl myristate, and optionally a miscibilizing agent compatible with organic solvent systems, and methods of controlling an ectoparasite infestation on certain animals comprising topically applying such formulations to the animal.

6927210, Aug 9, 2005

Aug 2, 2000

10/048239

William Webster Thompson - Indianapolis IN, US
Joseph Raymond Winkle - Indianapolis IN, US

Eli Lilly and Company - Indianapolis IN

A61K031/7042, C07H015/24

514 28, 424405, 536 65, 536 71

The invention provides a stable ectoparasiticidal aqueous suspension formulation of a spinosyn, comprising the spinosyn, or a physiologically acceptable derivative or salt thereof, milled to an average particle size of 1 to 15 microns, a surfactant in an amount effective to facilitate wetting the milled particles; a dispersant in an amount that forms a spinosyn;dispersant weight ration of from 3:1 to 1:5; and water. It also provides a method of controlling an ectoparasite infestation on a small ruminant or companion animal comprising administering an effective amount of such an aqueous suspension formulation.