Inventors:
Jerome S. Brody - Boston MA, US
Avrum Spira - Newton MA, US
Adam Gustafson - Portland OR, US
Andrea Bild - Salt Lake City UT, US
International Classification:
A61K 31/05, C12Q 1/68, C40B 30/04, C40B 40/08, A61P 35/00
US Classification:
514734, 435 6, 506 9, 506 17
Abstract:
The invention provides the identification of oncogenic pathways activated in cytologically normal airway cells of individuals having or at risk of having lung disease, as well as specific gene expression patterns (biomarkers) associated with pathway activation. These biomarkers and pathways may provide prognostic and/or diagnostic indicators in lung disease, e.g., lung cancer. Additionally, these pathways and biomarkers may provide therapeutic targets for the treatment of lung disease, as well as markers for the assessment of treatment efficacy.