JEFFREY C MURRAY, MD
Medical Practice at Hawkins Dr, Iowa City, IA

6518411, Feb 11, 2003

Nov 22, 1996

08/754477

Jeffrey C. Murray - Iowa City IA
Elena Semina - Coralville IA

University of Iowa - Iowa City IA

C07H 2104

536 231, 536 235, 536 2431, 536 2433, 536 245

The present invention relates to the discovery of novel genes encoding RGS polypeptides. Therapeutics, diagnostics and screening assays based on these molecules are also disclosed.

2005008, Apr 28, 2005

May 6, 2004

10/840139

Brian Schutte - Iowa City IA, US
Jeffrey Murray - Iowa City IA, US
Shinji Kondo - Iowa City IA, US
Michael Dixon - Manchester, GB

University of Iowa Research Foundation - Iowa City IA

C12Q001/68

435006000

This invention relates to polymorphisms in the IRF6 gene which are associated with various diseases, such as Van der Woude syndrome, Poplitieal syndrome, isolated cleft lip and/or palate, and other orofusial clefting disorders. The invention also relates to the nucleotide sequences of this gene, isolated nucleic acids comprising these nucleotide sequences, and isolated polypeptides or peptides encoded thereby. The invention further relates to vectors and host cells comprising the disclosed nucleotide sequences, or fragments thereof, as well as antibodies that bind to the encoded polypeptides or peptides. In addition the invention relates to methods and compositions employing the disclosed nucleic acids, polypeptides or peptides, or antibodies for use in diagnostics and therapeutics for IRF6 associated disorders, e.g., Van der Woude syndrome, Poplitieal syndrome, isolated cleft lip and/or palate, and other orofusial clefting disorders.

6306586, Oct 23, 2001

Oct 24, 1997

8/957351

Jeffrey C. Murray - Iowa City IA
Elena Semina - Coralville IA

University of Iowa Research Foundation - Iowa City IA

C12Q 168, C12N 1500, C12N 500, C07H 2104

435 6

The invention provides nucleic acids encoding Pitx3 polypeptides, fragments thereof and homologs thereof and Pitx3 polypeptides encoded thereby. Pitx3 polypeptides play an important role in development of eye structures, e. g. , the lens, and was shown herein to be associated with the formation of cataracts and Anterior Segment Mesenchymal Dysgenesis (ASMD). Thus, the invention provides methods for predicting whether a subject has or is at risk of developing cataracts or other disease associated with an aberrant Pitx3, by determining, e. g. , whether the subject has a genetic lesion in a Pitx3 gene, such as a 17 bp insertion, characteristic of cataract development and ASMD or a base pair substitution at codon 13. Methods for treating cataracts or diseases or conditions associated with an aberrant Pitx3, e. g. , by administering to the subject a Pitx3 therapeutic, are also disclosed, as well as assays for identifying Pitx3 therapeutics.

7141543, Nov 28, 2006

Mar 22, 2002

10/105004

Jeffrey C. Murray - Iowa City IA, US
Elena Semina - Coralville IA, US

University of Iowa Research Foundation - Iowa City IA

C07H 21/02, C07H 21/04

514 8, 536 231

The present invention relates to the discovery of novel genes encoding RIEG polypeptides. Therapeutics, diagnostics and screening assays based on these molecules are also disclosed.