Inventors:
James Elder - Ann Arbor MI, US
James Varani - Ann Arbor MI, US
International Classification:
A61K031/519, A61K031/517, A61K031/203, A61K031/07, A61K031/11
US Classification:
514/262100, 514/264110, 514/559000, 514/690000, 514/725000, 514/266400
Abstract:
Erb inhibitors used in combination with retinoids are effective to prevent skin injury otherwise caused by retinoids alone. A method of treating skin aging and similar skin disorders comprises administering retinoids in combination with erb inhibitors of the general formula
where E, E, and Einclude halo, aryl is an alkylcarbonyl or alkenylcarbonyl, and alkoxy is lower alkoxy optionally substituted with amino groups.