JOHN J VOORHEES, MD
Dermatology in Ann Arbor, MI

5266307, Nov 30, 1993

Mar 31, 1992

7/861138

John J. Voorhees - Ann Arbor MI
Christopher E. M. Griffiths - Ann Arbor MI
Charles N. Ellis - Ann Arbor MI

The Regents of the University of Michigan - Ann Arbor MI

A61K 742, A61K 748

424 59

Topical application of retinoic acid is effective for increasing the tyrosinase activity in the skin of people having light skin. Thus, topical application of retinoic acid may be used to effect a suntan in people having light skin and as a consequence protect against photodamage.

2002011, Aug 29, 2002

Dec 18, 2000

09/740242

James Varani - Ann Arbor MI, US
Gary Fisher - Ann Arbor MI, US
John Voorhees - Ann Arbor MI, US

A61K007/42, A61K007/00

424/059000, 424/400000, 424/401000

The invention is based on selective inhibition of the enzyme (MMP-1), which causes the dermal matrix damage in humans, while sparing the enzyme(s) (MMP-9 and perhaps MMP-2) which not only do not cause the damage (based on extrapolation from our in vitro collagen gel system to real skin) but actually “clear away” the damage produced by MMP-1 to restore normal function to the skin. Matrix metalloproteinase-1 (MMP-1; fibroblast collagenase) is induced by UV radiation from the sun and is naturally elevated in old age. Human fibroblasts exposed to the degradation products of MMP-1 contract collagen, but when this debris is removed from their environment, the fibroblasts behave normally. Inhibiting MMP-1 but sparing enzymes that remove the debris improves human skin after onslaught from solar UV radiation, old age, and acne.

6919072, Jul 19, 2005

Jun 10, 2003

10/458355

James Varani - Ann Arbor MI, US
Gary J. Fisher - Ann Arbor MI, US
John J. Voorhees - Ann Arbor MI, US
Sewon Kang - Ann Arbor MI, US

The Regents of the University of Michigan - Ann Arbor MI

A61K007/42, A61K007/00, A61K031/59, A61K031/185, A61K031/16, A61K031/07

424 59, 424 60, 424400, 424401, 514167, 514576, 514629, 514725

Chronological aging of human skin can be delayed with the topical application of an MMP inhibitor, preferably a retinoid (an indirect MMP inhbitor); retinoids also normalize procollagen biosynthesis. Chronological aging, or natural aging, is evidenced in elderly (80+ years old) skin by increased MMP levels and decreased procollagen levels when compared with younger individuals. Prophylactic treatment of not yet chronologically-aged skin with a retinoid both inhibits degradation of dermal collagen and restores procollagen synthesis. Biopsied sections from elderly skin show that a single treatment of chronologically-aged skin with a retinoid can increase epidermal thickness, improve the dermal collagen density, and promote the formation of rete pegs and dermal papillae. Such benefits are helpful in preventing bruising, tearing, and ulceration of elderly skin. Accordingly, prophylactic treatment begun much earlier in life with an MMP inhibitor and/or a retinoid delays the onset of such symptoms.

6942870, Sep 13, 2005

Apr 2, 2002

10/114651

Gary J. Fisher - Ann Abor MI, US
John J. Voorhees - Ann Arbor MI, US
Sewon Kang - Ann Arbor MI, US

The Regents of the University of Michigan - Ann Arbor MI

A61K007/00, A61K006/00, A61K007/42

424401, 424 59, 514725

Compositions and methods are provided for ameliorating various effects of UVA and UVB radiation from the sun. The compositions include an ingredient that prevents photoaging from MED and subMED radiation, namely a direct acting MMP (matrix metalloproteinase) inhibitor. The compositions can include another, indirect MMP inhibitor, such as a retinoid, certain other compounds (such as N-acetylcysteine, 2-furildioxime, and vitamin C), tetracyclines, and if a retinoid is used then in addition optional compounds that inhibit the CYP-26 (chytochrome P-450) mediated metabolism of retinoids such as ketoconazole and other azole compounds. In the method, the composition is applied prior to exposure to the sun; for direct acting MMP inhibitors, application should be just prior to exposure, and if indirect inhibitors such as retinoids are used in addition, then application of the indirect inhibitor should be at least about seven hours prior to exposure. Compounds that prevent erythema (skin reddening, sunburn) do not necessarily protect against UV-mediated elevation of MMP levels and activity, and similarly compounds that prevent UV-mediated elevation of MMP levels and activity are not necessarily effective against UV-induced erythema.

6017960, Jan 25, 2000

May 12, 1998

9/076355

John J. Voorhees - Ann Arbor MI
Charles N. Ellis - Ann Arbor MI
Christopher E. M. Griffiths - Manchester, GB

Regents of the University of Michigan - Ann Arbor MI

A61K 3119

514557

Treatment of post-inflammatory hyperpigmentation (PIH) in black and asian skin is accelerated from natural healing by use of a composition comprising a retinoid and/or an inhibitor of cytochrome P-450 enzyme-mediated degradation of retinoids, the composition does not require a conventional depigmenting or bleaching agent (such as a hydroquinone) as is typically used. Healing of PIH lesions is accelerated about three to five times from normal healing. Additionally, these compositions are useful separately for lightening black or asian skin.

4144332, Mar 13, 1979

Jun 21, 1977

5/808595

John J. Voorhees - Ann Arbor MI

The Regents of the University of Michigan - Ann Arbor MI

A61K 3156, A61K 31455

424240

A process for alleviating proliferative skin diseases such as psoriasis, atopic dermatitis, etc. comprising administering to humans, or domesticated animals, topically and/or systemically a composition comprising a pharmaceutical carrier and at least one active compound selected from certain anilino nicotinic acids used alone, or in mixtures, or in combination with a glucocorticoid.

2010017, Jul 15, 2010

Jan 12, 2010

12/686092

Gary J. Fisher - Ann Arbor MI, US
John J. Voorhees - Ann Arbor MI, US

The Regents of The University of Michigan - Ann Arbor MI

A61K 31/4045, A61K 31/4462, A61P 17/02, A61P 17/16, A61P 17/00, A61Q 17/04

424 59, 514419, 514357

Methods and compositions to prevent scarring of the skin include a matrix metalloproteinase inhibitor and a vehicle suitable for topical application. Scarring and damage to the epidermis and extracellular matrix may be reduced and/or prevented. Following skin damage, application of the matrix metalloproteinase inhibitor reduces expansion of the extracellular matrix portion of the skin compared to untreated skin.

4201788, May 6, 1980

Aug 11, 1978

5/932878

John J. Voorhees - Ann Arbor MI
Diane H. Russell - Tucson AZ

University Patents, Inc. - Stamford CT
The Regents of the University of Michigan - Ann Arbor MI

A61K 31275, A61K 3115

424304

A process and pharmaceutical compositions for alleviating proliferative skin diseases such as psoriasis, atopic dermatitis, etc. , comprising administering to humans or domesticated animals, topically and/or parenterally, and/or systemically a composition comprising a pharmaceutical carrier and at least one diamino compound selected from the diamines of saturated and unsaturated aliphatic hydrocarbons having 3 to 6 carbon atoms and the diamines of saturated monocarboxylic acids having 4 to 6 carbon atoms and the alkyl esters thereof containing from 1 to 4 carbon atoms. These diamino compounds are usable alone or in combination with certain prostaglandin compounds, certain phosphodiesterase inhibitor compounds and certain cyclic adenosine monophosphate compounds.

2002019, Dec 26, 2002

Sep 18, 2002

10/165048

Sewon Kang - Ann Arbor MI, US
John Voorhees - Ann Arbor MI, US
Gary Fisher - Ypsilanti MI, US

A61K007/42, A47B023/06

424/059000, 362/130000

Tanning can be effected much more safely if radiation limited to the range between 330 nm and 360 nm is used for tanning human skin. Other wavelengths, which may tend to induce MMPs, promote erythema, and/or cause DNA damage.

2012007, Mar 22, 2012

Jan 18, 2011

13/008416

Gary J. Fisher - Ann Arbor MI, US
Yiru Xu - Ann Arbor MI, US
John J. Voorhees - Ann Arbor MI, US

The Regents of The University of Michigan - Ann Arbor MI

A61K 8/96, A61Q 19/08, C12N 5/071, A61Q 17/04

424 59, 42419517, 435375, 435366

Methods are provided for ascertaining and measuring RPTP-κ activity in response to insults such as UV irradiation and with respect to administration of a treatment and/or composition. Attenuation of EGFR activity by RPTP-κ affects aspects of photoaging, including damage to the skin, suppression of the immune system, DNA damage, and connective tissue degradation. Intervention with respect to the effects of photoaging can include protection of RPTP-κ from oxidation. The methods can be used for discovery of anti-aging treatments, adjuncts, or other preventative treatments, such as sunscreens.