Inventors:
Bradford A. Jameson - Philadelphia PA
James M. McDonnell - Philadelphia PA
Robert Korngold - Cherry Hill NJ
Assignee:
Thomas Jefferson University - Philadelphia PA
International Classification:
A61K 3800, A61K 3804, C07K 500, C07K 700
Abstract:
Compounds which display a surface similar to the surface presented by one of five distinct lateral domains of CD4 are disclosed. Methods of treating individuals suspected of suffering from or susceptible to conditions characterized by an undesired immune response comprising administering to the individual at least one compound which mimics a portion of the lateral surface of the CD4 glycoprotein are disclosed.