JAMES A HOXIE
Medical Practice in Berwyn, PA
License number
Pennsylvania MD024571E
Category
Medicine
Type
Medical Physician and Surgeon
Address
Address
Berwyn, PA 19312
Professional information
Virus-Like Particles (Vlps) Comprising Heterologous Multiple Membrane Spanning Proteins
US Patent:
7763258, Jul 27, 2010
Filed:
Dec 21, 2001
Appl. No.:
10/032311
Inventors:
Robert Doms - Berwyn PA, US
Joseph Rucker - Philadelphia PA, US
Trevor L. Hoffman - Irvine CA, US
Paul Bates - Swarthmore PA, US
James Hoxie - Berwyn PA, US
Michael Endres - Painesville OH, US
John Balliet - Norristown PA, US
Dennis Kolson - Secane PA, US
Joseph Rucker - Philadelphia PA, US
Trevor L. Hoffman - Irvine CA, US
Paul Bates - Swarthmore PA, US
James Hoxie - Berwyn PA, US
Michael Endres - Painesville OH, US
John Balliet - Norristown PA, US
Dennis Kolson - Secane PA, US
Assignee:
The Trustees of the University of Pennsylvania - Philadelphia PA
International Classification:
A61K 39/12, A61K 39/205
US Classification:
4241991, 4242071, 4242081, 4242241
Abstract:
Enveloped virus vectors are described which comprise a cellular virus receptor protein and which are capable of fusing with a cell which comprises a viral envelope protein to which the cellular virus receptor protein is cognate. Enveloped virus vectors comprising a plurality of cellular virus receptor proteins are also described. Methods for making the enveloped virus vectors are described, as are methods of using the enveloped virus vectors. The invention further relates to a lipoparticle comprising a membrane spanning protein, and the lipoparticle can be attached to a sensor surface. The invention relates to methods of producing and using the lipoparticle to, inter alia, assess protein binding interactions.
Compositions, Method And Kits Relating To Deletion Mutations Of Immunodeficiency Virus Gp120 Hypervariable Regions
US Patent:
7524927, Apr 28, 2009
Filed:
Jan 29, 2004
Appl. No.:
10/767648
Inventors:
James A. Hoxie - Berwyn PA, US
George Lin - Voorhees NJ, US
George Lin - Voorhees NJ, US
Assignee:
The Trustees of the University of Pennsylvania - Philadelphia PA
International Classification:
C07K 14/00, A61K 38/10, C07H 21/04
US Classification:
530350, 4242081, 536 231
Abstract:
The present invention relates to replication competent variants of mammalian immunodeficiency virus comprising mutations and/or deletions of the V3 hypervariable loop and compensatory mutations, as well as methods for producing such variants. The invention also relates to V3-loop deletion mammalian immunodeficiency virus mutants that have compensatory mutations, deletions of the V1/V2 loops, or both. The invention further relates to isolated Env, gp120 polypeptides, and gp41 polypeptides comprising novel mutations useful in conjunction with, or separate from, a virus of the invention, as well as nucleic acids encoding the same.
Cd4-Independent Hiv Envelope Proteins As Vaccines And Therapeutics
US Patent:
6420545, Jul 16, 2002
Filed:
Jun 22, 1999
Appl. No.:
09/337387
Inventors:
James A. Hoxie - Berwyn PA
Celia C. LaBranche - Chapel Hill NC
Robert W. Doms - Berwyn PA
Trevor L. Hoffman - Lansdowne PA
Celia C. LaBranche - Chapel Hill NC
Robert W. Doms - Berwyn PA
Trevor L. Hoffman - Lansdowne PA
Assignee:
The Trustees of the University of Pennsylvania - Philadelphia PA
Duke University - Durham NC
Duke University - Durham NC
International Classification:
C07H 2104
US Classification:
536 2372, 4242081, 435 691, 4352351, 4353201, 514 44, 536 231, 536 234, 935 32
Abstract:
The invention relates to novel CD4-independent HIV Envelope proteins and uses therefor.
Method For The Preparation Of Virus-Like Particles (Vlps) Comprising Heterologous Multiple Membrane Spanning Proteins
US Patent:
8158130, Apr 17, 2012
Filed:
Mar 9, 2010
Appl. No.:
12/720398
Inventors:
Robert W Doms - Berwyn PA, US
Joseph Rucker - Philadelphia PA, US
Trevor L Hoffman - Irvine CA, US
Paul Bates - Swarthmore PA, US
James A Hoxie - Berwyn PA, US
Michael J Endres - Painesville OH, US
John Balliet - Norristown PA, US
Dennis L Kolson - Secane PA, US
Joseph Rucker - Philadelphia PA, US
Trevor L Hoffman - Irvine CA, US
Paul Bates - Swarthmore PA, US
James A Hoxie - Berwyn PA, US
Michael J Endres - Painesville OH, US
John Balliet - Norristown PA, US
Dennis L Kolson - Secane PA, US
Assignee:
The Trustees of the University of Pennsylvania - Philadelphia
International Classification:
A61K 39/12, C12P 21/06, C12N 15/00
US Classification:
4241991, 435 691, 4353201
Abstract:
Enveloped virus vectors are described which comprise a cellular virus receptor protein and which are capable of fusing with a cell which comprises a viral envelope protein to which the cellular virus receptor protein is cognate. Enveloped virus vectors comprising a plurality of cellular virus receptor proteins are also described. Methods for making the enveloped virus vectors are described, as are methods of using the enveloped virus vectors. The invention further relates to a lipoparticle comprising a membrane spanning protein, and the lipoparticle can be attached to a sensor surface. The invention relates to methods of producing and using the lipoparticle to, inter alia, assess protein binding interactions.
Antibodies Directed Against Cellular Coreceptors For Human Immunodeficiency Virus And Methods Of Using The Same
US Patent:
RE39057, Apr 4, 2006
Filed:
Apr 22, 2004
Appl. No.:
10/829475
Inventors:
James A. Hoxie - Berwyn PA, US
Assignee:
The Trustees of the University of Pennsylvania - Philadelphia PA
International Classification:
C07K 16/28
US Classification:
53038822, 5303871, 5303891, 4241431, 4241441
Abstract:
The invention relates to an anti-immunodeficiency virus antibody which binds to a cellular protein and diagnostic and therapuetic methods of using the same.
Method And Kit For Detection Of Thrombin Receptor Activation Of Platelets And Other Cells
US Patent:
5840499, Nov 24, 1998
Filed:
Jun 6, 1996
Appl. No.:
8/659486
Inventors:
Lawrence Brass - Bala Cynwyd PA
James A. Hoxie - Berwyn PA
James A. Hoxie - Berwyn PA
Assignee:
Trustees of the University of Pennsylvania - Philadelphia PA
International Classification:
G01N 3353, G01N 33543, C07K 700, C07K 1628
US Classification:
435 71
Abstract:
Method for detecting thrombin-induced cell activation via a system of detection capable of determining the presence of the cleaved peptide fragment of the thrombin receptor are provided. These methods are used in diagnosing and treating a pre-thrombotic state or thrombotic disorder in a patient. Detection kits to be used with this method are also provided.
Antibodies Directed Against Cellular Coreceptors For Human Immunodeficiency Virus And Methods Of Using The Same
US Patent:
5994515, Nov 30, 1999
Filed:
Jun 25, 1997
Appl. No.:
8/882435
Inventors:
James A. Hoxie - Berwyn PA
Assignee:
Trustees of the University of Pennsylvania - Philadelphia PA
International Classification:
C07K 1628
US Classification:
53038822
Abstract:
The invention relates to an anti-immunodeficiency virus antibody which binds to a cellular protein and diagnostic and therapuetic methods of using the same.
Lipoparticle Comprising A Protein And Methods Of Making And Using The Same
US Patent:
2012019, Aug 2, 2012
Filed:
Mar 15, 2012
Appl. No.:
13/421559
Inventors:
Robert Doms - Berwyn PA, US
Joseph Rucker - Philadelphia PA, US
Trevor L. Hoffman - Irvine CA, US
Paul Bates - Swarthmore PA, US
James Hoxie - Berwyn PA, US
Michael Endres - Painesville OH, US
John Balliet - Norristown PA, US
Dennis Kolson - Secane PA, US
Joseph Rucker - Philadelphia PA, US
Trevor L. Hoffman - Irvine CA, US
Paul Bates - Swarthmore PA, US
James Hoxie - Berwyn PA, US
Michael Endres - Painesville OH, US
John Balliet - Norristown PA, US
Dennis Kolson - Secane PA, US
International Classification:
A61K 39/12, A61P 37/04, C12N 7/00, A61K 39/395
US Classification:
4241301, 4241991, 4352351
Abstract:
Enveloped virus vectors are described which comprise a cellular virus receptor protein and which are capable of fusing with a cell which comprises a viral envelope protein to which the cellular virus receptor protein is cognate. Enveloped virus vectors comprising a plurality of cellular virus receptor proteins are also described. Methods for making the enveloped virus vectors are described, as are methods of using the enveloped virus vectors. The invention further relates to a lipoparticle comprising a membrane spanning protein, and the lipoparticle can be attached to a sensor surface. The invention relates to methods of producing and using the lipoparticle to, inter alia, assess protein binding interactions.
Cd4-Independent Hiv Envelope Proteins As Vaccines And Therapeutics
US Patent:
7371846, May 13, 2008
Filed:
Feb 1, 2005
Appl. No.:
11/048554
Inventors:
James A. Hoxie - Berwyn PA, US
Celia C. LaBranche - Chapel Hill NC, US
Robert W. Doms - Berwyn PA, US
Trevor L. Hoffman - Lansdowne PA, US
Celia C. LaBranche - Chapel Hill NC, US
Robert W. Doms - Berwyn PA, US
Trevor L. Hoffman - Lansdowne PA, US
Assignee:
The Trustees of the University of Pennsylvania - Philadelphia PA
International Classification:
C07H 21/04
US Classification:
536 2372, 4242081, 435 691, 4352351, 4353201
Abstract:
The invention relates to novel CD4-independent HIV Envelope proteins and uses therefor.
Cd4-Independent Hiv Envelope Proteins As Vaccines And Therapeutics
US Patent:
6849261, Feb 1, 2005
Filed:
Jul 16, 2002
Appl. No.:
10/196515
Inventors:
James A. Hoxie - Berwyn PA, US
Celia C. LaBranche - Chapel Hill NC, US
Robert W. Doms - Berwyn PA, US
Trevor L. Hoffman - Lansdowne PA, US
Celia C. LaBranche - Chapel Hill NC, US
Robert W. Doms - Berwyn PA, US
Trevor L. Hoffman - Lansdowne PA, US
Assignee:
The Trustees of the University of Pennsylvania - Philadelphia PA
International Classification:
A61K 3921
US Classification:
4242081, 435 691, 4352351, 536 2372
Abstract:
The invention relates to novel CD4-independent HIV Envelope proteins and uses therefor.