Inventors:
Barbara A. Araneo - Salt Lake City UT
Raymond A. Daynes - Park City UT
Urszula Orlinska - Hockessin DE
Imad S. Farrukh - Salt Lake City UT
Assignee:
University of Utah Research Foundation - Salt Lake City UT
Pharmadigm, Inc. - Salt Lake City UT
International Classification:
A61K 3156
Abstract:
The present invention is related to a method for preventing or reducing the effects of ischemia. The ischemia may be associated with injury or reperfusion injury, such as occurs as a result of infarctions, thermal injury (bums), surgical trauma, accidental trauma, hemorrhagic shock and the like. The invention is also related to methods for preventing, or reducing bacterial translocation, adult respiratory distress syndrome, adherence of blood cells and platelets to endothelial cells and pulmonary hypertension. In accordance with the present invention, these conditions are prevented or reduced by administering a dehydroepiandrosterone (DHEA) derivative as defined herein.