Harold C Nielson
Hearing Aid Provider in Salt Lake City, UT
License number
Utah 103038-8914
Issued Date
Dec 30, 1992
Expiration Date
Dec 31, 1994
Category
xControlled Substance Handler
Type
Controlled Substance Handler Individual
Address
Address
Salt Lake City, UT
Professional information
Immunomodulatory Activity Of Exogenous Melatonin Following Traumatic Injury
US Patent:
5519047, May 21, 1996
Filed:
Apr 20, 1994
Appl. No.:
8/230543
Inventors:
Jane Shelby - Park City UT
Harold C. Nielson - Salt Lake City UT
Harold C. Nielson - Salt Lake City UT
Assignee:
University of Utah Research Foundation - Salt Lake City UT
International Classification:
A61K 3140
US Classification:
514419
Abstract:
A method of decreasing elevated levels of IL-6 and. gamma. -IFN that are secreted in response to traumatic injury in a warm-blooded animal is disclosed, comprising the step of administering an effective amount of melatonin to the animal. The melatonin should be administered so as to provide a peak amount of circulating melatonin at a time in the animal's daily cycle when endogenous melatonin reaches peak amounts. Elevated levels of IL-6 and. gamma. -IFN are also decreased by exposing the animal to certain daily regimens of light and dark, such as 24 hours of dark. Cell-mediated immune response to a contact antigen is also enhanced by administration of exogenous melatonin.