HOWARD TRACHTMAN
Medical Practice in New Rochelle, NY

License number

Pennsylvania TL000357B

Personal information

See more information about HOWARD TRACHTMAN at radaris.com

Name

Address

Phone

Howard Trachtman

1650 Arch St, Philadelphia, PA 19103

(215) 669-6798

Howard Trachtman

1830 Addison St, Philadelphia, PA 19146

Howard Trachtman, age 70

33 Lovell Rd, New Rochelle, NY 10804

(914) 772-6239

Howard Trachtman

Philadelphia, PA

(215) 545-2907

Howard Trachtman

1650 Arch St, Philadelphia, PA 19103

(215) 977-2116

Professional information

See more information about HOWARD TRACHTMAN at trustoria.com

Method For Inhibiting Expression Of Inducible Nitric Oxide Synthase With Tetracycline

US Patent:

5919775, Jul 6, 1999

Filed:

Apr 16, 1998

Appl. No.:

9/061286

Inventors:

Ashok R. Amin - Union NJ
Steven B. Abramson - Rye NY
Lorne M. Golub - Smithtown NY
Nungavaram S. Ramamurthy - Smithtown NY
Thomas F. McNamara - Port Jefferson NY
Robert A. Greenwald - Melville NY
Howard Trachtman - New Rochelle NY

Assignee:

The Research Foundation of The State University of New York - Stony Brook NY
Hospital For Joint Diseases - New York NY

International Classification:

A61K 3165

US Classification:

514152

Abstract:

The invention is a method of inhibiting the production of nitric oxide (NO) in an in vivo, in vitro, or ex vivo biological system. The method employs a tetracycline compound to inhibit the production of NO and/or to inhibit the expression or activity of an inducible isoform of nitric oxide synthase (iNOS). Preferably, the tetracycline compound has inhibitory activity for metalloproteinases. Also it is preferred that the tetracycline compound is provided to the biological system in an amount which has little or no antibacterial activity in the system. Accordingly, preferred tetracycline compounds are tetracycline compounds which have be modified to reduce or eliminate their antimicrobial activity. The method can be used to treat medical conditions in mammals characterized by NO production mediated by iNOS, including, for example, inflammatory conditions.

Method Of Using Tetracycline Compounds For Inhibition Of Endogenous Nitric Oxide Production

US Patent:

5789395, Aug 4, 1998

Filed:

Aug 30, 1996

Appl. No.:

8/697815

Inventors:

Assignee:

The Research Foundation of State University of New York - Albany NY
Hospital for Joint Diseases - New York NY

International Classification:

A61K 3165, C12N 999, C12N 904, C12N 906

US Classification:

514152

Abstract:

A method is disclosed for inhibiting endogenous production of nitric oxide (NO) in an in vivo, in vitro, or ex vivo mammalian system. The method employs a tetracycline compound to inhibit production of NO and/or to inhibit the expression or activity of an inducible isoform of nitric oxide synthase (iNOS). Preferably, the tetracycline compound has inhibitory activity for metalloproteinases. Also it is preferred that the tetracycline compound is provided to the mammalian system in an amount which has little or no antibacterial activity in the system. Accordingly, preferred tetracycline compounds are tetracycline compounds which have be modified to reduce or eliminate their antimicrobial activity. The method can be used to treat medical conditions in mammals characterized by NO production mediated by iNOS, including, for example, inflammatory conditions.