HOWARD TRACHTMAN
Medical Practice in New Rochelle, NY
License number
Pennsylvania TL000357L
Category
Medicine
Type
Temporary MD License
Address
Address
2
New Rochelle, NY 10804
Pennsylvania
Pennsylvania
Personal information
See more information about HOWARD TRACHTMAN at radaris.comName
Address
Phone
1650 Arch St, Philadelphia, PA 19103
1830 Addison St, Philadelphia, PA 19146
33 Lovell Rd, New Rochelle, NY 10804
Philadelphia, PA
1650 Arch St, Philadelphia, PA 19103
Professional information
Method For Inhibiting Expression Of Inducible Nitric Oxide Synthase With Tetracycline
US Patent:
5919775, Jul 6, 1999
Filed:
Apr 16, 1998
Appl. No.:
9/061286
Inventors:
Ashok R. Amin - Union NJ
Steven B. Abramson - Rye NY
Lorne M. Golub - Smithtown NY
Nungavaram S. Ramamurthy - Smithtown NY
Thomas F. McNamara - Port Jefferson NY
Robert A. Greenwald - Melville NY
Howard Trachtman - New Rochelle NY
Steven B. Abramson - Rye NY
Lorne M. Golub - Smithtown NY
Nungavaram S. Ramamurthy - Smithtown NY
Thomas F. McNamara - Port Jefferson NY
Robert A. Greenwald - Melville NY
Howard Trachtman - New Rochelle NY
Assignee:
The Research Foundation of The State University of New York - Stony Brook NY
Hospital For Joint Diseases - New York NY
Hospital For Joint Diseases - New York NY
International Classification:
A61K 3165
US Classification:
514152
Abstract:
The invention is a method of inhibiting the production of nitric oxide (NO) in an in vivo, in vitro, or ex vivo biological system. The method employs a tetracycline compound to inhibit the production of NO and/or to inhibit the expression or activity of an inducible isoform of nitric oxide synthase (iNOS). Preferably, the tetracycline compound has inhibitory activity for metalloproteinases. Also it is preferred that the tetracycline compound is provided to the biological system in an amount which has little or no antibacterial activity in the system. Accordingly, preferred tetracycline compounds are tetracycline compounds which have be modified to reduce or eliminate their antimicrobial activity. The method can be used to treat medical conditions in mammals characterized by NO production mediated by iNOS, including, for example, inflammatory conditions.
Method Of Using Tetracycline Compounds For Inhibition Of Endogenous Nitric Oxide Production
US Patent:
5789395, Aug 4, 1998
Filed:
Aug 30, 1996
Appl. No.:
8/697815
Inventors:
Ashok R. Amin - Union NJ
Steven B. Abramson - Rye NY
Lorne M. Golub - Smithtown NY
Nungavaram S. Ramamurthy - Smithtown NY
Thomas F. McNamara - Port Jefferson NY
Robert A. Greenwald - Melville NY
Howard Trachtman - New Rochelle NY
Steven B. Abramson - Rye NY
Lorne M. Golub - Smithtown NY
Nungavaram S. Ramamurthy - Smithtown NY
Thomas F. McNamara - Port Jefferson NY
Robert A. Greenwald - Melville NY
Howard Trachtman - New Rochelle NY
Assignee:
The Research Foundation of State University of New York - Albany NY
Hospital for Joint Diseases - New York NY
Hospital for Joint Diseases - New York NY
International Classification:
A61K 3165, C12N 999, C12N 904, C12N 906
US Classification:
514152
Abstract:
A method is disclosed for inhibiting endogenous production of nitric oxide (NO) in an in vivo, in vitro, or ex vivo mammalian system. The method employs a tetracycline compound to inhibit production of NO and/or to inhibit the expression or activity of an inducible isoform of nitric oxide synthase (iNOS). Preferably, the tetracycline compound has inhibitory activity for metalloproteinases. Also it is preferred that the tetracycline compound is provided to the mammalian system in an amount which has little or no antibacterial activity in the system. Accordingly, preferred tetracycline compounds are tetracycline compounds which have be modified to reduce or eliminate their antimicrobial activity. The method can be used to treat medical conditions in mammals characterized by NO production mediated by iNOS, including, for example, inflammatory conditions.