Inventors:
Randy Tressler - Forest Hill MD, US
Hernan Valdez - New York NY, US
International Classification:
A61K 31/675, A61P 31/14, A61K 31/427, A61P 31/18, A61K 31/439, A61K 31/4402
US Classification:
514 81, 514304, 514357, 514365
Abstract:
The present invention discloses a novel combination therapy for HIV-1 treatment relying on a combination of at least one CCR5 antagonist, at least one HIV-1 protease inhibitor and at least one pharmacokinetic enhancer of said at least one CCR5 antagonist and/or at least one HIV-1 protease inhibitor. The combination is intended for use in oral treatment of a disorder selected from the group consisting of HIV-1 infection, retroviral infections genetically related to HIV and AIDS, in a treatment-naïve patient infected with CCR5 tropic HIV-1 virus.