Inventors:
Sekhar BODDUPALLI - San Jose CA, US
Bing WANG - Cupertino CA, US
Guy M. MILLER - Monte Sereno CA, US
International Classification:
C07D 319/08, C07D 295/096, C07D 311/58
US Classification:
51425411, 514452, 514456, 514458
Abstract:
The invention relates the method of treatment or amelioration of mitochondrial disorders such as Alzheimer's disease, Parkinson's disease, Friedreich's ataxia (FRDA), cerebellar ataxias, Leber's hereditary optic neuropathy (LHON), mitochondrial myopathy, encephalopathy, lactacidosis, stroke (MELAS), Myoclonic Epilepsy with Ragged Red Fibers (MERFF), amyotrophic lateral sclerosis (ALS), motor neuron diseases, Huntington's disease, macular degeneration, and epilepsy, with chroman derivatives of Formula I or Formula II as described herein.