DR. LAURENCE JAY MARTON, M.D.
Medical Practice at Military Way, Palo Alto, CA
License number
California G18863
Category
Medical Practice
Type
Clinical Pathology/Laboratory Medicine
Address
Address
581 Military Way, Palo Alto, CA 94306
Phone
(650) 494-1818
Organization information
See more information about LAURENCE JAY MARTON at bizstanding.comLaurence Jay Marton M.D
581 Military Way, Palo Alto, CA 94306
Industry:
Medical Doctor's Office
Principal:
Laurence J. Marton Principal, inactive
Professional information
Dr. Laurence J Marton, Palo Alto CA - MD (Doctor of Medicine)
Specialties:
Clinical Pathology
Address:
581 Military Way, Palo Alto 94306
(650) 494-1818 (Phone)
(650) 494-1818 (Phone)
Languages:
English
Education:
Medical School
Albert Einstein College of Medicine of Yeshiva University
Graduated: 1969
Albert Einstein College of Medicine of Yeshiva University
Graduated: 1969
Conformationally Restricted Polyamine Analogs As Disease Therapies
US Patent:
2007016, Jul 12, 2007
Filed:
Dec 20, 2006
Appl. No.:
11/643592
Inventors:
Benjamin Frydman - Madison WI, US
Linda Clifford - Madison WI, US
Laurence Marton - Palo Alto CA, US
Venodhar Reddy - Madison WI, US
Aldonia Valasinas - Buenos Aires, AR
Andrei Blokhin - Fitchburg WI, US
Hirak Basu - Madison WI, US
Linda Clifford - Madison WI, US
Laurence Marton - Palo Alto CA, US
Venodhar Reddy - Madison WI, US
Aldonia Valasinas - Buenos Aires, AR
Andrei Blokhin - Fitchburg WI, US
Hirak Basu - Madison WI, US
Assignee:
Cellgate, Inc. - Redwood City CA
International Classification:
A61K 31/409, A61K 31/13, C07D 487/22, C07C 211/13, C07C 211/17
US Classification:
514410000, 514660000, 514671000, 540145000, 564452000, 564509000
Abstract:
Novel conformationally restricted polyamine analogs are provided, as well as compositions comprising these novel polyamine analogs. Methods of using the novel polyamine analogs in treatment of diseases such as cancer are also provided. Also provided is a method of delivering these analogs specifically to tumor cells by covalently attaching polyamine analogs to porphyrin compounds, along with novel polyamine-porphyrin covalent conjugates.
Polyamine Analog Conjugates And Quinone Conjugates As Therapies For Cancers And Prostate Diseases
US Patent:
7279502, Oct 9, 2007
Filed:
Oct 20, 2004
Appl. No.:
10/970089
Inventors:
Linda Clifford, legal representative - Madison WI, US
Laurence J. Marton - Palo Alto CA, US
Laurence J. Marton - Palo Alto CA, US
Assignee:
Cellgate, Inc. - Redwood City CA
International Classification:
A61K 31/131, A61K 31/132, C07K 211/13, C07K 211/17
US Classification:
514659, 514674, 564455, 564512
Abstract:
Peptide conjugates in which cytocidal and cytostatic agents, such as polyamine analogs or naphthoquinones, are conjugated to a polypeptide recognized and cleaved by enzymes such as prostate-specific antigen (PSA) and cathepsin B are provided, as well as compositions comprising these conjugates. Methods of using these conjugates in the treatment of prostate diseases are also provided.
Treatment And Prevention Of Vascular Hyperplasia Using Polyamine And Polyamine Analog Compounds
US Patent:
2007023, Oct 4, 2007
Filed:
Mar 14, 2007
Appl. No.:
11/724521
Inventors:
Laurence Marton - Palo Alto CA, US
Randolph Johnson - Half Moon Bay CA, US
Randolph Johnson - Half Moon Bay CA, US
International Classification:
A61K 31/409, A61K 31/13
US Classification:
514410000, 514579000, 514671000, 514674000
Abstract:
This disclosure relates to methods of inhibiting vascular hyperplasia using polyamines, polyamine analogs, and conformationally restricted polyamine analogs, or a conjugate of a polyamine, polyamine analog, or conformationally restricted polyamine analog. Polyamines, polyamine analogs, conformationally restricted polyamine analogs, and conjugates thereof are useful in reducing stenosis and restenosis of blood vessels and grafts.
Polyamine Analog-Amino Acid Conjugates Useful As Anticancer Agents
US Patent:
7312244, Dec 25, 2007
Filed:
Nov 8, 2001
Appl. No.:
10/415377
Inventors:
Linda Clifford, legal representative - Madison WI, US
Laurence J. Marton - Palo Alto CA, US
Aldonia L. Valasinas - Buenos Aires, AR
Venodhar K. Reddy - Madison WI, US
Laurence J. Marton - Palo Alto CA, US
Aldonia L. Valasinas - Buenos Aires, AR
Venodhar K. Reddy - Madison WI, US
Assignee:
Cellgate, Inc. - Redwood City CA
International Classification:
A61K 31/27, C07C 205/00, C07C 261/00
US Classification:
514477, 514478, 514479, 514642, 514740, 560 23, 560 25
Abstract:
Conjugates in which polyamine analogs are conjugated to an amino acid are provided, as well as compositions comprising these conjugates. Methods of using these conjugates as anticancer treatments are also provided.
Novel Polyamine Analog Conjugates And Quinone Conjugates As Therapies For Cancers And Prostate Diseases
US Patent:
2008019, Aug 14, 2008
Filed:
Oct 8, 2007
Appl. No.:
11/868910
Inventors:
Benjamin Frydman - Madison WI, US
Linda Clifford - Madison WI, US
Laurence J. Marton - Palo Alto CA, US
Linda Clifford - Madison WI, US
Laurence J. Marton - Palo Alto CA, US
International Classification:
A61K 31/132, A61P 35/00
US Classification:
514659
Abstract:
Peptide conjugates in which cytostatic and cytostatic agents, such as polyamine analogs or naphthoquinones, are conjugated to a polypeptide recognized and cleaved by enzymes such as prostate-specific antigen (PSA) and cathepsin B are provided, as well as compositions comprising these conjugates. Methods of using these conjugates in the treatment of prostate diseases are also provided.
Cycloalkyl Substituted Polyamines For Cancer Therapy And Methods Of Synthesis Therefor
US Patent:
6982351, Jan 3, 2006
Filed:
Dec 6, 2002
Appl. No.:
10/313530
Inventors:
Benjamin Frydman - Madison WI, US
Andrei V. Blokhin - Fitchburg WI, US
Aparajita Sarkar - Madison WI, US
Hirak S. Basu - Madison WI, US
Venodhar K. Reddy - Madison WI, US
Laurence J. Marton - Palo Alto CA, US
Yu Wang - Madison WI, US
Andrei V. Blokhin - Fitchburg WI, US
Aparajita Sarkar - Madison WI, US
Hirak S. Basu - Madison WI, US
Venodhar K. Reddy - Madison WI, US
Laurence J. Marton - Palo Alto CA, US
Yu Wang - Madison WI, US
Assignee:
CellGate, Inc. - Redwood City CA
International Classification:
C07C 211/17
US Classification:
564453, 564153, 564445, 564454, 564455, 564457, 564461
Abstract:
Conformationally restricted polyamine compounds useful in treatment of cancer and other diseases marked by abnormal cell proliferation are disclosed. Improved methods of synthesizing such compounds are also disclosed. In one method of the invention, a carbene-bearing or carbene equivalent-bearing compound is reacted with the double bond of an alkene compound to form a cyclopropyl ring as the first step in the synthesis.
Cycloalkyl Substituted Polyamines For Cancer Therapy And Methods Of Synthesis Therefor
US Patent:
7453011, Nov 18, 2008
Filed:
Jun 4, 2007
Appl. No.:
11/810409
Inventors:
Linda Clifford, legal representative - Madison WI, US
Andrei V. Blokhin - Fitchburg WI, US
Aparajita Sarkar - Madison WI, US
Hirak S. Basu - Madison WI, US
Venodhar K. Reddy - Madison WI, US
Laurence J. Marton - Palo Alto CA, US
Yu Wang - Madison WI, US
Andrei V. Blokhin - Fitchburg WI, US
Aparajita Sarkar - Madison WI, US
Hirak S. Basu - Madison WI, US
Venodhar K. Reddy - Madison WI, US
Laurence J. Marton - Palo Alto CA, US
Yu Wang - Madison WI, US
Assignee:
Progen Pharmaceuticals, Inc. - Redwood City CA
International Classification:
C07C 211/13, A61K 31/13
US Classification:
564461, 564452, 564455, 564457, 514674
Abstract:
Conformationally restricted polyamine compounds useful in treatment of cancer and other diseases marked by abnormal cell proliferation are disclosed. Improved methods of synthesizing such compounds are also disclosed. In one method of the invention, a carbene-bearing or carbene equivalent-bearing compound is reacted with the double bond of an alkene compound to form a cyclopropyl ring as the first step in the synthesis.
Oligoamine Compounds And Derivatives Thereof For Cancer Therapy
US Patent:
7491849, Feb 17, 2009
Filed:
Oct 1, 2004
Appl. No.:
10/957105
Inventors:
Linda Clifford, legal representative - Madison WI, US
Aldonia L. Valasinas - Buenos Aires, AR
Andrei V. Blokhin - Madison WI, US
Hirak S. Basu - Madison WI, US
Laurence J. Marton - Palo Alto CA, US
Venodhar K. Reddy - Madison WI, US
Aldonia L. Valasinas - Buenos Aires, AR
Andrei V. Blokhin - Madison WI, US
Hirak S. Basu - Madison WI, US
Laurence J. Marton - Palo Alto CA, US
Venodhar K. Reddy - Madison WI, US
Assignee:
Progen Pharmaceuticals, Inc. - Redwood City CA
International Classification:
C07C 211/13, A61K 31/13
US Classification:
564512, 514674
Abstract:
Oligoamine compounds with anti-cancer and anti-proliferative activity are provided, as well as methods for making and using the compounds. The compounds are shown to be active against prostate cancer cell lines and against prostate cancer tumors in mice. The compounds are also useful in treatment of breast cancer and other cancers.
Oligoamine Compounds And Derivatives Thereof For Cancer Therapy
US Patent:
2009012, May 14, 2009
Filed:
Jan 21, 2009
Appl. No.:
12/357323
Inventors:
Benjamin Frydman - , US
Linda Clifford - Madison WI, US
Aldonia L. Valasinas - Buenos Aires, AR
Andrei V. Blokhin - Fitchburg WI, US
Hirak S. Basu - Madison WI, US
Laurence J. Marton - Palo Alto CA, US
Venodhar K. Reddy - Madison WI, US
Linda Clifford - Madison WI, US
Aldonia L. Valasinas - Buenos Aires, AR
Andrei V. Blokhin - Fitchburg WI, US
Hirak S. Basu - Madison WI, US
Laurence J. Marton - Palo Alto CA, US
Venodhar K. Reddy - Madison WI, US
Assignee:
Progen Pharmaceuticals, Inc. - Redwood City CA
International Classification:
C07C 237/06
US Classification:
564197
Abstract:
Oligoamine compounds with anti-cancer and anti-proliferative activity are provided, as well as methods for making and using the compounds. The compounds are shown to be active against prostate cancer cell lines and against prostate cancer tumors in mice. The compounds are also useful in treatment of breast cancer and other cancers.