Inventors:
John W. Babich - Scituate MA
Jon Zubieta - Syracuse NY
Grant Bonavia - Kensington MD
Assignee:
Biostream, Inc. - Cambridge MA
International Classification:
A61K 914
Abstract:
In one aspect, biocompatible matrices such as sol-gels encapsulating a reaction center may be administered to a subject for conversion of prodrugs into biologically active agents. In certain embodiments, the biocompatible matrices of the present invention are sol-gels. In one embodiment, the enzyme -amino acid decarboxylase is encapsulated and implanted in the brain to convert -dopa to dopamine for treatment of Parkinsons disease.