JAMES BRIAN HODGE, MSPT
Medical Practice at Wisconsin Ave, Bethesda, MD
License number
Maryland 20338
Category
Medical Practice
Type
Specialist
Address
Address
2
5454 Wisconsin Ave SUITE 1555, Bethesda, MD 20815
320 Inspiration Ln, Gaithersburg, MD 20878
320 Inspiration Ln, Gaithersburg, MD 20878
Phone
(301) 951-8593
(301) 951-8598 (Fax)
(301) 990-7773
(301) 951-8598 (Fax)
(301) 990-7773
Personal information
See more information about JAMES BRIAN HODGE at radaris.comName
Address
Phone
6005 Sefton Ave, Baltimore, MD 21214
Professional information
James Hodge - Gaithersburg, MD
Work:
Asher Investment Group - Gaithersburg, MD
Lead custodial engineer Magruder's - Gaithersburg, MD
Janitor Service Solutions - Gaithersburg, MD
Janitor National Public Radio - Washington, DC
Janitor Supervisor / Attendant
Lead custodial engineer Magruder's - Gaithersburg, MD
Janitor Service Solutions - Gaithersburg, MD
Janitor National Public Radio - Washington, DC
Janitor Supervisor / Attendant
Education:
Spingarn High School - Washington, DC
Diploma
Diploma
Enhanced Immune Response To An Antigen By A Composition Of A Recombinant Virus Expressing The Antigen With A Recombinant Virus Expressing An Immunostimulatory Molecule
US Patent:
6548068, Apr 15, 2003
Filed:
Jan 7, 2000
Appl. No.:
09/480340
Inventors:
Jeffrey Schlom - Potamac MD
Judith Kantor - Rockville MD
James W. Hodge - Gaithersburg MD
Judith Kantor - Rockville MD
James W. Hodge - Gaithersburg MD
Assignee:
The United States of America as represented by the Secretary of the Department of Health and Human Services - Washington DC
International Classification:
A61K 3900
US Classification:
4241991, 4242321, 4242041, 4353201, 4352351, 435325, 530350, 5303871, 536 2372
Abstract:
The present invention is a composition of recombinant virus which has incorporated into its genome or portion thereof a gene encoding an antigen to a disease causing agent and a recombinant virus which has incorporated into its genome or portion thereof a gene encoding an immunostimulatory molecule(s) for the purpose of stimulating an immune response against the disease causing agent. Methods of treatment of diseases such as cancer and diseases caused by pathogenic microorganisms is provide using the composition.
Recombinant Vector Expressing Multiple Costimulatory Molecules And Uses Thereof
US Patent:
7771715, Aug 10, 2010
Filed:
Mar 21, 2007
Appl. No.:
11/723666
Inventors:
Jeffrey Schlom - Potomac MD, US
James Hodge - Gaithersburg MD, US
Dennis Panicali - Acton MA, US
James Hodge - Gaithersburg MD, US
Dennis Panicali - Acton MA, US
Assignee:
The United States of America as represented by the Department of Health and Human Services - Washington DC
International Classification:
A61K 48/00, C12N 15/00
US Classification:
424 931, 4353201
Abstract:
The present invention is a recombinant vector encoding and expressing at least three or more costimulatory molecules. The recombinant vector may additionally contain a gene encoding one or more target antigens or immunological epitope thereof. The synergistic effect of these costimulatory molecules on the enhanced activation of T cells is demonstrated. The degree of T-cell activation using recombinant vectors containing genes encoding three costimulatory molecules was far greater than the sum of recombinant vector constructs containing one costimulatory molecule and greater than the use of two costimulatory molecules. Results employing the triple costimulatory vectors were most dramatic under conditions of either low levels of first signal or low stimulator to T-cell ratios. This phenomenon was observed with both isolated CD4 and CD8 T cells. The recombinant vectors of the present invention are useful as immunogenes and vaccines against cancer and pathogenic micro-organisms, and in providing host cells, including dendritic cells and splenocytes with enhanced antigen-presenting functions.
Enhanced Immune Response To An Antigen By A Composition Of A Recombinant Virus Expressing The Antigen With A Recombinant Virus Expressing An Immunostimulatory Molecule
US Patent:
6893869, May 17, 2005
Filed:
Jan 14, 2003
Appl. No.:
10/341431
Inventors:
Jeffrey Schlom - Potamac MD, US
Judith Kantor - Rockville MD, US
James W. Hodge - Gaithersburg MD, US
Judith Kantor - Rockville MD, US
James W. Hodge - Gaithersburg MD, US
Assignee:
The United States of America as represented by the Secretary of the Department of Health and Human Services - Washington DC
International Classification:
C12N005/00
US Classification:
435325, 4352351, 435 691, 4353201
Abstract:
The present invention is a composition of recombinant virus which has incorporated into its genome or portion thereof a gene encoding an antigen to a disease causing agent and a recombinant virus which has incorporated into its genome or portion thereof a gene encoding an immunostimulatory molecule(s) for the purpose of stimulating an immune response against the disease causing agent. Methods of treatment of diseases such as cancer and diseases caused by pathogenic microorganisms is provide using the composition.
Recombinant Vector Expressing Multiple Costimulatory Molecules And Uses Thereof
US Patent:
6969609, Nov 29, 2005
Filed:
Nov 12, 1999
Appl. No.:
09/856988
Inventors:
Jeffrey Schlom - Potomac MD, US
James Hodge - Gaithersburg MD, US
Dennis Panicali - Acton MA, US
James Hodge - Gaithersburg MD, US
Dennis Panicali - Acton MA, US
Assignee:
The United States of America as represented by the Department of Health and Human Serivces - Washingtown DC
International Classification:
C12N005/10, C12N005/16, C12N005/22, C12N015/85, A16K048/00
US Classification:
435325, 4353651, 4353201, 435360, 435362, 435372, 4353721, 435374, 435375, 435377, 435376, 435366, 435385, 435386, 424 931, 424 91, 424 851
Abstract:
The present invention is a recombinant vector encoding and expressing at least three or more costimulatory molecules. The recombinant vector may additionally contain a gene encoding one or more target antigens or immunological epitope thereof. The synergistic effect of them costimulatory molecules on the enhanced activation of T cells is demonstrated. The degree of T-cell activation using recombinant vectors containing genes encoding three costimulatory molecules was far greater than the sum of recombinant vector constructs containing one costimulatory molecule and greater that the use of two costimulatory molecules. Results employing the triple costimulatory vectors were most dramatic under conditions of either low levels of first signal or low stimulator to T-cell ratios. This phenomenon was observed with both isolated CD4and CD8T cells. The recombinant vectors of the present invention are useful as immunogenes and vaccines against cancer and pathogenic micro-organisms, and in providing host cells, including dendritic cells and splenocytes with enhanced and antigen-presenting functions.
Enhanced Immune Response To An Antigen By A Composition Of A Recombinant Virus Expressing The Antigen With A Recombinant Virus Expressing An Immunostimulatory Molecule
US Patent:
6045802, Apr 4, 2000
Filed:
Jun 7, 1995
Appl. No.:
8/483316
Inventors:
Jeffrey Schlom - Potamac MD
Judith Kantor - Rockville MD
James W. Hodge - Gaithersburg MD
Judith Kantor - Rockville MD
James W. Hodge - Gaithersburg MD
Assignee:
The United States of America as represented by the Secretary of the
Department Of Health and Human Services - Washington DC
Department Of Health and Human Services - Washington DC
International Classification:
A61K 3900, C12N 1500
US Classification:
4241991
Abstract:
The present invention is a composition of recombinant virus which has incorporated into its genome or portion thereof a gene encoding an antigen to a disease causing agent and a recombinant virus which has incorporated into its genome or portion thereof a gene encoding an immunostimulatory molecule(s) for the purpose of stimulating an immune response against the disease causing agent. Methods of treatment of diseases such as cancer and diseases caused by pathogenic microorganisms is provide using the composition.
Recombinant Vector Expressing Multiple Costimulatory Molecules And Uses Thereof
US Patent:
7211432, May 1, 2007
Filed:
Apr 4, 2003
Appl. No.:
10/406317
Inventors:
Jeffrey Schlom - Potomac MD, US
James Hodge - Gaithersburg MD, US
Dennis Panicali - Acton MA, US
James Hodge - Gaithersburg MD, US
Dennis Panicali - Acton MA, US
Assignee:
The United States of America, as represented by the Secretary, Department of Health and Human Services - Washington DC
International Classification:
C12N 15/00, C12N 15/39, C12N 15/19, C12N 7/00
US Classification:
4353201, 4351961, 424 851
Abstract:
The present invention is a recombinant vector encoding and expressing at least three or more costimulatory molecules. The recombinant vector may additionally contain a gene encoding one or more target antigens or immunological epitope thereof. The synergistic effect of these costimulatory molecules on the enhanced activation of T cells is demonstrated. The degree of T-cell activation using recombinant vectors containing genes encoding three costimulatory molecules was far greater than the sum of recombinant vector constructs containing one costimulatory molecule and greater than the use of two costimulatory molecules. Results employing the triple costimulatory vectors were most dramatic under conditions of either low levels of first signal or low stimulator to T-cell ratios. This phenomenon was observed with both isolated CD4 and CD8 T cells. The recombinant vectors of the present invention are useful as immunogenes and vaccines against cancer and pathogenic micro-organisms, and in providing host cells, including dendritic cells and splenocytes with enhanced antigen-presenting functions.
Method Of Enhancing A Targeted Immune Response Against Tumors
US Patent:
7368116, May 6, 2008
Filed:
Mar 28, 2005
Appl. No.:
11/090686
Inventors:
Jeffrey Schlom - Potomac MD, US
Judith Kantor - Rockville MD, US
James W. Hodge - Gaithersburg MD, US
Judith Kantor - Rockville MD, US
James W. Hodge - Gaithersburg MD, US
Assignee:
The United States of America as represented by the Department of Health and Human Services - Washington DC
International Classification:
A61K 39/12
US Classification:
4241991, 4242321, 4242041, 435 691
Abstract:
The present invention is a composition of recombinant virus which has incorporated into its genome or portion thereof a gene encoding an antigen to a disease causing agent and a recombinant virus which has incorporated into its genome or portion thereof a gene encoding an immunostimulatory molecule(s) for the purpose of stimulating an immune response against the disease causing agent. Methods of treatment of diseases such as cancer and diseases caused by pathogenic microorganisms is provide using the composition.
Method Of Enhancing A Targeted Immune Response Against Tumors
US Patent:
7662395, Feb 16, 2010
Filed:
Apr 30, 2008
Appl. No.:
12/112819
Inventors:
Jeffrey Schlom - Potomac MD, US
Judith Kantor - Rockville MD, US
James W. Hodge - Gaithersburg MD, US
Judith Kantor - Rockville MD, US
James W. Hodge - Gaithersburg MD, US
Assignee:
The United States of America as represented by the Department of Health and Human Services - Washington DC
International Classification:
A61K 39/12
US Classification:
4241991, 4353201
Abstract:
The present invention is a composition of recombinant virus which has incorporated into its genome or portion thereof a gene encoding an antigen to a disease causing agent and a recombinant virus which has incorporated into its genome or portion thereof a gene encoding an immunostimulatory molecule(s) for the purpose of stimulating an immune response against the disease causing agent. Methods of treatment of diseases such as cancer and diseases caused by pathogenic microorganisms is provide using the composition.