Inventors:
Sanjay Bhanot - Carlsbad CA, US
Gerald Shulman - East Haven CT, US
Assignee:
Yale University - New Haven CT
Isis Pharmaceuticals, Inc. - Carlsbad CA
International Classification:
A61K 31/7088
Abstract:
Provided herein are methods, compounds, and compositions for reducing expression of phosphoenolpyruvate carboxykinase-mitochondrial (PEPCK-M) mRNA and protein in an animal. Also provided herein are methods, compounds, and compositions for preventing or decreasing diabetes, obesity, metabolic syndrome, diabetic dyslipidemia, and/or hypertriglyceridemia in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate any one or more of diabetes, obesity, metabolic syndrome, diabetic dyslipidemia, and/or hypertriglyceridemia, or a symptom thereof.