GAVRIL W PASTERNAK, MD
Neurology at York Ave, New York, NY
License number
New York 135658
Category
Neurology
Type
Neurology
Address
Address
1275 York Ave, New York, NY 10021
Phone
(212) 639-2000
Personal information
See more information about GAVRIL W PASTERNAK at radaris.comName
Address
Phone
1725 York Ave APT 30B, New York, NY 10128
500 E 83Rd St APT 21M, New York, NY 10028
New York, NY
500 83Rd St, New York, NY 10028
500 83Rd St, New York, NY 10028
Professional information
Professor At Mskcc
Position:
Anne Burnett Tandy Chair in Neurology and Laboratory Head, Molecular Pharamcology and Chemistry at MSKCC
Location:
Greater New York City Area
Industry:
Research
Work:
MSKCC
since Jan 1979
-
Anne Burnett Tandy Chair in Neurology and Laboratory Head, Molecular Pharamcology and Chemistry
Education:
The Johns Hopkins University School of Medicine 1969 - 1975
MD, PhD, Pharmacology The Johns Hopkins University 1965 - 1969
BA, Chemistry
MD, PhD, Pharmacology The Johns Hopkins University 1965 - 1969
BA, Chemistry
Gavril W Pasternak, New York NY
Specialties:
Neurologist
Address:
1275 York Ave, New York, NY 10065
633 3Rd Ave, New York, NY 10017
633 3Rd Ave, New York, NY 10017
Education:
Johns Hopkins University - Doctor of Philosophy*
Johns Hopkins University, School of Medicine - Doctor of Medicine*
Johns Hopkins University, School of Medicine - Doctor of Medicine*
Board certifications:
American Board of Psychiatry and Neurology Certification in Neurology (Psychiatry and Neurology)*
Identification And Characterization Of Multiple Splice Variants Of The Kappa3-Related Opioid Receptor (Kor-3) Gene
US Patent:
6627734, Sep 30, 2003
Filed:
Mar 13, 2001
Appl. No.:
09/743871
Inventors:
Gavril Pasternak - New York NY
Ying-Xian Pan - New York NY
Ying-Xian Pan - New York NY
Assignee:
Memorial Sloan-Kettering Cancer Center - New York NY
International Classification:
C07K 100
US Classification:
530350, 435 6, 435 71, 435 721, 435 695, 4352523, 4353201, 436501, 514 2, 514 44, 530 235
Abstract:
The present invention encompasses novel splice variant forms of the muopioid receptor-1 (KOR-3) and the polynucleotide sequences encoding the KOR-3 splice variants. The invention further encompasses methods of screening for compositions regulating the KOR-3 splice variant activities and the development of therapeutic modalities directed to regulating activity. Regulation of the KOR-3 splice variant activities may impact the physiologic processes of analgesia and weight management.
Methods And Compositions For Treating Pain Of The Mucous Membrane
US Patent:
6509028, Jan 21, 2003
Filed:
Jun 17, 2002
Appl. No.:
10/172455
Inventors:
Robert O. Williams - Austin TX
Feng Zhang - Austin TX
John J. Koleng - Austin TX
Gavril W. Pasternak - New York NY
Yuri A. Kolesnikov - Tenafly NJ
Feng Zhang - Austin TX
John J. Koleng - Austin TX
Gavril W. Pasternak - New York NY
Yuri A. Kolesnikov - Tenafly NJ
Assignee:
EpiCept Corporation - Englewood Cliffs NJ
International Classification:
A61F 1300
US Classification:
424434, 424443, 424486, 514817, 514818
Abstract:
Compositions useful for long-lasting pain relief from mucosal damage, such as mucosal inflamation, abrasions, ulcerations, lesions, trauma and incisions, without significant systemic absorption. The compositions of the invention are particularly suitable for application to the mucous membrane of the nasal cavity and buccal cavity. To relieve pain, the compositions or the invention are topically applied directly to the affected area.
Nucleic Acid Molecules Encoding Kappa3, Opioid Receptors, Receptors Encoded Thereby, And Uses Thereof
US Patent:
2003010, Jun 5, 2003
Filed:
Dec 27, 2002
Appl. No.:
10/331028
Inventors:
Gavril Pasternak - New York NY, US
Ying-Xian Pan - New York NY, US
Ying-Xian Pan - New York NY, US
International Classification:
C12P021/02, C12N005/06, C07K014/705, G01N033/567, C07H021/04
US Classification:
435/069100, 435/007210, 435/320100, 435/325000, 530/350000, 536/023500
Abstract:
The subject invention provides recombinant nucleic acid molecule which encodes a kappaopioid receptor, and the receptor encoded thereby. The subject invention further provides related anti-sense oligonucleotide molecules. The subject invention further provides a related host vector system, and method for using same. The subject invention further provides polyclonal and monoclonal antibodies capable of specifically binding to kappaopioid receptor, methods for obtaining same, and methods of using same to detect the presence of, and quantitatively determine the amount of, kappaopioid receptor in a sample, image and quantitatively determine the amount of cell membrane-bound kappaopioid receptor present in a subject, determine a subject's potential sensitivity to a kappaopioid receptor-specific agent, determine the affinity of an agent for kappaopioid receptor, and identify agonists and antagonists of kappaopioid receptor.
6-Amido Derivatives Of 4, 5-A Epoxymorphinans For The Treatment Of Pain
US Patent:
2013028, Oct 31, 2013
Filed:
Oct 19, 2011
Appl. No.:
13/879908
Inventors:
Gavril Pasternak - New York NY, US
Susruta Majumdar - Stamford CT, US
Susruta Majumdar - Stamford CT, US
Assignee:
MEMORIAL SLOAN-KETTERING CANCER CENTER - New York NY
International Classification:
C07D 489/08
US Classification:
514282, 546 44, 435 721
Abstract:
Compounds of formula:in which Ris chosen from substituted phenyl, optionally substituted naphthylene, optionally substituted anthracene and optionally substituted aromatic heterocycle, are useful as analgesics.
Methods And Compositions For Treating Pain Of The Mucous Membrane
US Patent:
2002001, Jan 31, 2002
Filed:
Jun 25, 2001
Appl. No.:
09/888466
Inventors:
Robert Williams - Austin TX, US
Feng Zhang - Austin TX, US
John Koleng - Austin TX, US
Gavril Pasternak - New York NY, US
Yuri Kolesnikov - Tenafly NJ, US
Feng Zhang - Austin TX, US
John Koleng - Austin TX, US
Gavril Pasternak - New York NY, US
Yuri Kolesnikov - Tenafly NJ, US
International Classification:
A61K031/485, A61K009/14
US Classification:
514/282000, 424/486000
Abstract:
Compositions useful for long-lasting pain relief from mucosal damage, such as mucosal inflamation, abrasions, ulcerations, lesions, trauma and incisions, without significant systemic absorption. The compositions of the invention are particularly suitable for application to the mucous membrane of the nasal cavity and buccal cavity. To relieve pain, the compositions or the invention are topically applied directly to the affected area.
Opiate Agonists And Antagonists
US Patent:
4608376, Aug 26, 1986
Filed:
Sep 30, 1982
Appl. No.:
6/430630
Inventors:
Gavril W. Pasternak - New York NY
International Classification:
C07D49122, C07D47118, A61K 31485
US Classification:
514282
Abstract:
Dihydromorphinone compound of the general formula
HDM. dbd. N--R
wherein
HDM is ##STR1## where * indicates binding carbon
R1 is an optionally substituted alkyl, alkylene, cycloalkyl, or cycloalkylene
R2 is OH or H
R3 is OH or OCH3 and
R is N. dbd. R4, N--R4, ##STR2## R4 is an optionally substituted alkyl, alkylene, cycloalkyl, cycloalkylene, aryl, heterocycloalkyl, heterocycloalkylene, or alkenyl, and
n is 1-10, and use thereof as an opiate receptor blocker.
Identification And Characterization Of Multiple Splice Variants Of The Mu-Opioid Receptor Gene
US Patent:
2003010, Jun 5, 2003
Filed:
Oct 29, 2002
Appl. No.:
10/283300
Inventors:
Gavril Pasternak - New York NY, US
Ying-Xian Pan - New York NY, US
Ying-Xian Pan - New York NY, US
International Classification:
A61K039/395, C07H021/04, C07K014/705, C12P021/02, C12N005/06
US Classification:
424/143100, 530/350000, 536/023500, 435/069100, 435/320100, 435/325000
Abstract:
The present invention encompasses novel splice variant forms of the mu-opioid receptor-1 (MOR-1) and the polynucleotide sequences encoding the MOR-1 splice variants. The invention further encompasses methods of screening for compositions regulating the MOR-1 splice variant activities and the development of therapeutic modalities directed to regulating activity. Regulation of the MOR-1 splice variant activities may impact the physiologic processes of analgesia and weight management.
Opiate Agonists And Antagonists
US Patent:
4803208, Feb 7, 1989
Filed:
Oct 11, 1985
Appl. No.:
6/786879
Inventors:
Gavril W. Pasternak - New York NY
Assignee:
Sloan-Kettering Institute For Cancer Research - New York NY
International Classification:
C07D48908, C07D47108, A61K 31485
US Classification:
514282
Abstract:
Dihydromorphinone compound of the general formula
HDM. dbd. N--R
wherein ##STR1## where * indicates binding carbon R1 is an optionally substituted alkyl, alkylene, cycloalkyl, or cycloalkylene
R2 is OH or H
R3 is OH or OCH3 and
R is N. dbd. R4, N--R4, ##STR2## R4 is an optionally substituted alkyl, alkylene, cycloalkyl, cycloalkylene, aryl, heterocycloalkyl, heterocycloalkylene, or alkenyl, and
n is 1-10, and use thereof as an opiate receptor blocker.