PAOLO L MANFREDI, MD
Neurology at York Ave, New York, NY

2004018, Sep 16, 2004

Mar 14, 2003

10/389476

Gilbert Gonzales - New York NY, US
James Young - West Chester OH, US
Ralph Heasley - Union KY, US
Paolo Manfredi - New York NY, US

Xanodyne Pharmacal, Inc. - Florence KY

A61K031/485

514/282000

Compositions and methods for parenterally administering methadone. The methadone composition may be administered in a sterile, preservative-free formulation, or in a formulation including a chlorobutanol-free, government approved preservative. The methadone formulations are administered parenterally, such as intravenously or topically, for many applications including the treatment of pain resulting from chronic disorders, cancer, acute symptoms and the like.

2005005, Mar 10, 2005

Jun 15, 2004

10/868227

Franco Folli - Milano, IT
Paolo Manfredi - New York NY, US
Gilbert Gonzales - New York NY, US

A61K031/535, A61K031/155

514635000

A multi-system therapy which is adapted to treat diabetes, metabolic syndrome and obesity includes a hypoglycemic agent, a lipid lowering agent, a blood pressure lowering agent and, preferably, an anti-platelet agent. The composition can further include various vitamins and supplements such as vitamin B6, vitamin B12, arginin, a folate and other vitamins and minerals. Preferably, the hypoglycemic agent is a biguanide hypoglycemic agent without any additional hypoglycemic agent, making the composition suitable for treatment of individuals who are not hyperglycemic as well as those who are hyperglycemic.

2005006, Mar 24, 2005

Sep 24, 2003

10/669490

Gilbert Gonzales - New York NY, US
Paolo Manfredi - New York NY, US

A61K031/485, A61K009/14, A61K009/68

514282000, 424048000, 424440000

Pharmaceutical compositions for oral-transmucosally administering methadone. For oral transmucosal delivery, the compositions comprise an oral dissolution agent and methadone in a dosage formulation. The dissolution agent generally causes the formulation to break down or dissolve in the oral cavity. The formulation is buffered to a pH of at least 6 for substantial absorption of the methadone through the oral mucosal tissue from the dissolved dosage form.

2005010, May 12, 2005

Nov 6, 2003

10/702893

Gilbert Gonzales - New York NY, US
Paolo Manfredi - New York NY, US

PediaMed Pharmaceuticals, Inc. - Exton PA

A61M031/00

604514000

A pharmaceutical composition for administration to a patient body. The composition includes a physiologically-acceptable formulation including at least one active pharmaceutical ingredient, wherein said physiologically-acceptable formulation including said at least one active pharmaceutical ingredient is provided in a delivery form, said delivery form being administrable to a patient body through a plurality of administration routes, which include the oral and rectal routes.

2007001, Jan 18, 2007

Jul 3, 2006

11/428417

Franco Folli - Milano, IT
Gilbert Gonzales - New York NY, US
Paolo Manfredi - New York NY, US

A61K 31/155, B65D 85/42

514635000, 206530000

A daily dosage regimen for treating diabetes, obesity and metabolic syndrome includes a metabolic pill and one or two biguanide hypoglycemic pills packaged together. The package can include a singe day's regiment, or can include multiple days' regimen. This provides an effective method for treating diabetes, obesity and metabolic syndrome, as well as polycystic ovary syndrome.