Inventors:
Frederick P. Siegal - New York NY, US
Michael Shodell - New York NY, US
Assignee:
The Feinstein Institute for Medical Research - Manhasset NY
International Classification:
A61K 49/00, A61K 35/12, A61K 35/14, C12Q 1/00, G01N 33/53, G01N 33/567
US Classification:
424 91, 435 4, 435 71, 435 72, 435 721, 424 92, 424520, 424529, 424534
Abstract:
The present invention provides compositions for the treatment, inhibition or prevention of diseases or disorders, including cancer, immune diseases or disorders, and infectious diseases, comprising interferon-producing cells (IPCs) and methods of administering the IPCs. The present invention also provides compositions for the treatment, inhibition or prevention of diseases or disorders, including cancer, immune diseases or disorders, and infectious disease, comprising purified interferon (IFN) from IPCs and methods of administering the IFN. The present invention further provides methods for monitoring the progression of a disease or a disorder such as HIV infection or cancer, comprising measuring the abundance of IPCs in lymphoid organs or blood samples from a subject suffering from a disease or disorder.