DR. FENG ZHANG, MD
Radiology at Pasteur Dr, Palo Alto, CA
License number
California 125.061311
Category
Osteopathic Medicine
Type
Internal Medicine
License number
California A147915
Category
Radiology
Type
Diagnostic Radiology
Address
Address
300 Pasteur Dr, Palo Alto, CA 94305
Phone
(650) 723-4000
Professional information
System For Optical Stimulation Of Target Cells
US Patent:
2010019, Jul 29, 2010
Filed:
Jan 9, 2008
Appl. No.:
12/522528
Inventors:
Feng Zhang - Stanford CA, US
Karl Deisseroth - Palo Alto CA, US
David J. Mishelevich - Playa Del Rey CA, US
M. Bret Schneider - Portola Valley CA, US
Karl Deisseroth - Palo Alto CA, US
David J. Mishelevich - Playa Del Rey CA, US
M. Bret Schneider - Portola Valley CA, US
International Classification:
C12N 13/00, C12N 5/079
US Classification:
4351731, 435375
Abstract:
Stimulation of target cells using light, e.g., in vivo, is implemented using a variety of methods and devices. In one example, embodiments involve methods for stimulating target cells using a photosensitive protein that allows the target cells to be stimulated in response to light. In another specific example embodiment, target cells are stimulated using an implantable arrangement. The arrangement includes an electrical light-generation means for generating light and a biological portion. The biological portion has a photosensitive bio-molecular arrangement that responds to the generated light by stimulating target cells in vivo. Other aspects and embodiments are directed to systems and methods for screening chemicals based screening chemicals to identify their effects on cell membrane ion channels and pumps, and to systems and methods for controlling an action potential of neuron (e.g., in vivo and in vitro environments).
Optical Tissue Interface Method And Apparatus For Stimulating Cells
US Patent:
2009008, Apr 2, 2009
Filed:
Aug 4, 2008
Appl. No.:
12/185624
Inventors:
ALEXANDER ARAVANIS - San Diego CA, US
KARL DEISSEROTH - Palo Alto CA, US
FENG ZHANG - Stanford CA, US
M. BRET SCHNEIDER - Portola Valley CA, US
JAMIE M. HENDERSON - Stanford CA, US
KARL DEISSEROTH - Palo Alto CA, US
FENG ZHANG - Stanford CA, US
M. BRET SCHNEIDER - Portola Valley CA, US
JAMIE M. HENDERSON - Stanford CA, US
International Classification:
A61N 5/06, A61K 31/7088
US Classification:
604 21, 514 44, 607 80
Abstract:
In one example, a system electrically stimulates target cells of a living animal using an elongated structure, a modulation circuit and a light pathway such as provided by an optical fiber arrangement. The elongated structure is for insertion into a narrow passageway in the animal such that an end of the elongated structure is sufficiently near the target cells to deliver stimulation thereto. The modulation circuit is for modulating the target cells while the elongated structure is in the narrow passageway, where the modulation circuit is adapted to deliver viral vectors through the elongated structure for expressing light responsive proteins in the target cells. The light pathway is used for stimulating the target cells by delivering light to the light-responsive proteins in the target cells.
Systems, Methods And Compositions For Optical Stimulation Of Target Cells
US Patent:
2011030, Dec 8, 2011
Filed:
Aug 12, 2011
Appl. No.:
13/208419
Inventors:
Feng Zhang - Stanford CA, US
Karl Deisseroth - Palo Alto CA, US
Viviana Gradinaru - Palo Alto CA, US
Karl Deisseroth - Palo Alto CA, US
Viviana Gradinaru - Palo Alto CA, US
International Classification:
A61M 37/00, C12N 13/00
US Classification:
604 20, 4351731
Abstract:
Stimulation of target cells using light, e.g., in vivo or in vitro, is implemented using a variety of methods and devices. One example involves a vector for delivering a light-activated NpHR-based molecule comprising a nucleic acid sequence that codes for light-activated NpHR-based molecule and a promoter. Either a high expression of the molecule manifests a toxicity level that is less than about 75%, or the light-activated NpHR-based proteins are expressed using at least two NpHR-based molecular variants. Each of the variants characterized in being useful for expressing a light-activated NpHR-based molecule that responds to light by producing an inhibitory current to dissuade depolarization of the neuron. Other aspects and embodiments are directed to systems, methods, kits, compositions of matter and molecules for ion pumps or for controlling inhibitory currents in a cell (e.g., in in vivo and in vitro environments).
Systems, Methods And Compositions For Optical Stimulation Of Target Cells
US Patent:
2009009, Apr 9, 2009
Filed:
Mar 3, 2008
Appl. No.:
12/041628
Inventors:
Feng Zhang - Stanford CA, US
Karl Deisseroth - Palo Alto CA, US
Viviana Gradinaru - Palo Alto CA, US
Karl Deisseroth - Palo Alto CA, US
Viviana Gradinaru - Palo Alto CA, US
International Classification:
A61K 38/17, C07H 21/04, C07K 14/435, A61P 25/00, C12N 15/63
US Classification:
514 12, 536 235, 530350, 4353201
Abstract:
Stimulation of target cells using light, e.g., in vivo or in vitro, is implemented using a variety of methods and devices. One example involves a vector for delivering a light-activated NpHR-based molecule comprising a nucleic acid sequence that codes for light-activated NpHR-based molecule and a promoter. Either a high expression of the molecule manifests a toxicity level that is less than about 75%, or the light-activated NpHR-based proteins are expressed using at least two NpHR-based molecular variants. Each of the variants characterized in being useful for expressing a light-activated NpHR-based molecule that responds to light by producing an inhibitory current to dissuade depolarization of the neuron. Other aspects and embodiments are directed to systems, methods, kits, compositions of matter and molecules for ion pumps or for controlling inhibitory currents in a cell (e.g., in in vivo and in vitro environments).
Cell Line, System And Method For Optical-Based Screening Of Ion-Channel Modulators
US Patent:
2009009, Apr 16, 2009
Filed:
Aug 7, 2008
Appl. No.:
12/187927
Inventors:
Karl Deisseroth - Palo Alto CA, US
Feng Zhang - Stanford CA, US
Viviana Gradinaru - Palo Alto CA, US
M. Bret Schneider - Portola Valley CA, US
Feng Zhang - Stanford CA, US
Viviana Gradinaru - Palo Alto CA, US
M. Bret Schneider - Portola Valley CA, US
International Classification:
C40B 30/10, C12N 5/06, C12M 1/00, C40B 60/12, C12Q 1/02
US Classification:
506 12, 435325, 4352887, 506 39, 435 29
Abstract:
A variety of applications, systems, methods and constructs are implemented for use in connection with screening of ion-channel modulators. Consistent with one such system, drug candidates are screened to identify their effects on cell membrane ion channels and pumps. The system includes screening cells having light responsive membrane ion switches, voltage-gated ion switches and fluorescence producing voltage sensors. A chemical delivery device introduces the drug candidates to be screened. An optical delivery device activates the light responsive ion switches. An optical sensor monitors fluorescence produced by the voltage sensors. A processor processes data received from the optical sensor. A memory stores the data received from the optical sensor.
Method And Composition For Controlling Gene Expression
US Patent:
2011022, Sep 15, 2011
Filed:
Aug 11, 2009
Appl. No.:
13/057695
Inventors:
Karl Deisseroth - Palo Alto CA, US
Feng Zhang - Palo Alto CA, US
Feng Zhang - Palo Alto CA, US
International Classification:
C12P 21/00, C12N 15/85, C12N 5/071
US Classification:
435 691, 4353201, 435325
Abstract:
A composition for expressing a protein in cells is provided. In certain embodiments, a circular expression vector provided herein comprises: a promoter, a coding sequence encoding a protein of interest, in which the coding sequence is in a reversed 3′-5′ orientation, a transcription termination sequence, and at least a first recombination site and a second recombination site flanking the coding sequence. A method for using the disclosed composition and a kit comprising the composition are also provided herein.